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Sökning: WFRF:(Lin Chan Chiao)

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1.
  • Chiu, Pei-Fang, et al. (författare)
  • Design, structure–activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin–based sulfamates as steroid sulfatase inhibitors
  • 2023
  • Ingår i: Bioorganic chemistry. - : Elsevier BV. - 0045-2068. ; 138, s. 106581-106581
  • Tidskriftsartikel (refereegranskat)abstract
    • Inhibition of steroid sulfatase (STS) decreases estrogen production and thus, suppresses tumor proliferation. Inspired by irosustat, the first STS inhibitor in clinical trials, we explored twenty-one tricyclic and tetra-heterocyclic coumarin–based derivatives. Their STS enzyme kinetic parameters, docking models, and cytotoxicity toward breast cancer and normal cells were evaluated. Tricyclic derivative 9e and tetracyclic derivative 10c were the most promising irreversible inhibitors developed in this study, with KI of 0.05 and 0.4 nM, and kinact/KI ratios of 28.6 and 19.1 nM−1min−1 on human placenta STS, respectively.
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2.
  • Michelena, Nestor, et al. (författare)
  • Design of an Advanced Heavy Tactical Trucks : A Target Cascading Case Study
  • 2001
  • Ingår i: International Truck and Bus Meeting and Exhibition. - Warrendale, Pa : Society of Automotive Engineers, Incorporated.
  • Konferensbidrag (refereegranskat)abstract
    • The target cascading methodology is applied to the conceptual design of an advanced heavy tactical truck. Two levels are defined: an integrated truck model is represented at the top (vehicle ) level and four independent suspension arms are represented at the lower (system ) level. Necessary analysis models are developed, and design problems are formulated and solved iteratively at both levels. Hence, vehicle design variables and system specifications are determined in a consistent manner. Two different target sets and two different propulsion systems are considered. Trade-offs between conflicting targets are identified. It is demonstrated that target cascading can be useful in avoiding costly design iterations late in the product development process.
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