| 1. |
- Gawell, Malin, 1964-, et al.
(författare)
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Innovationslabb för social inkludering : Erfarenheter från Vinnova-finansierade projekt
- 2020. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- I boken presenteras en analys av erfarenheterna från tio projekt som finansieras inom Vinnovas utlysning ”Social innovation mot segregation – finansiering av innovationslabb för ökad inkludering” under perioden 2017-2019. Analysen bygger på projektledarnas erfarenheter av att leda och organisera innovationslabben, som dokumenterats genom workshops, enkät och projektmaterial. Rapporten är framtagen inom ramen för det kunskapsstöd som letts av Ideell Arena i samarbete med Södertörns högskola och Luleå tekniska universitet.
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| 2. |
- Jansson, Malin, et al.
(författare)
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Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers
- 2022
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Ingår i: Frontiers in Molecular Biosciences. - : Frontiers Media SA. - 2296-889X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is the most common cause of cancer death among women worldwide. Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality remains high for tumors that metastasize early. Type IV collagen is a basement membrane protein, and breach of this extracellular matrix structure is the first step of cancer invasion. Type IV collagen is found in the stroma of many cancers, but its role in tumor biology is unclear. Here, expression of type IV collagen in the stroma of small breast cancers was analyzed, correlated to clinically used prognostic biomarkers and patient survival. The findings were further validated in an independent gene expression data cohort. Tissue samples from 1,379 women with in situ and small invasive breast cancers (<= 15 mm) diagnosed in 1986-2004 were included. Primary tumor tissue was collected into tissue microarrays. Type IV collagen expression in tissues was visualized using immunohistochemistry. Gene expression data was extracted from the Cancer Genome Atlas database. Out of 1,379 women, 856 had an invasive breast cancer and type IV collagen staining was available for 714 patients. In Kaplan-Meier analysis high type IV collagen expression was significantly associated (p = 0.026) with poorer breast cancer specific survival. There was no correlation of type IV collagen expression to clinically used prognostic biomarkers. High type IV collagen expression was clearly associated to distant metastasis (p = 0.002). In an external validation cohort (n = 1,104), high type IV collagen mRNA expression was significantly (p = 0.041) associated with poorer overall survival, with overexpression of type IV collagen mRNA in metastatic tissue. Stromal type IV collagen expression in the primary tumor correlates to poor breast cancer specific survival most likely due to a higher risk of developing distant metastasis. This ECM protein may function as biomarker to predict the risk of future metastatic disease in patients with breast cancers.
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| 4. |
- Jansson, Malin, 1978-, et al.
(författare)
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Stromal type I collagen in breast cancer : correlation to prognostic biomarkers and prediction of chemotherapy response
- 2024
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Ingår i: Clinical Breast Cancer. - : Elsevier. - 1526-8209 .- 1938-0666.
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Fibrillar collagens accumulate in the breast cancer stroma and appear as poorly defined spiculated masses in mammography imaging. The prognostic value of tissue type I collagen remains elusive in treatment-naïve and chemotherapy-treated breast cancer patients. Here, type I collagen mRNA and protein expression were analysed in 2 large independent breast cancer cohorts. Levels were related to clinicopathological parameters, prognostic biomarkers, and outcome.Method: COL1A1 mRNA expression was analysed in 2509 patients with breast cancer obtained from the cBioPortal database. Type I collagen protein expression was studied by immunohistochemistry in 1395 women diagnosed with early invasive breast cancer.Results: Low COL1A1 mRNA and protein levels correlated with poor prognosis features, such as hormone receptor negativity, high histological grade, triple-negative subtype, node positivity, and tumour size. In unadjusted analysis, high stromal type I collagen protein expression was associated with improved overall survival (OS) (HR = 0.78, 95% CI = 0.61-0.99, p = .043) and trended towards improved breast cancer–specific survival (BCSS) (HR = 0.65, 95% CI = 0.42-1.01, P = 0.053), although these findings were lost after adjustment for other clinical variables. In unadjusted analysis, high expression of type I collagen was associated with better OS (HR = 0.70, 95% CI = 0.55-0.90, P = .006) and BCSS (HR = 0.55, 95% CI = 0.34-0.88, P = .014) among patients not receiving chemotherapy. Strikingly, the opposite was observed among patients receiving chemotherapy. There, high expression of type I collagen was instead associated with worse OS (HR = 1.83, 95% CI = 0.65-5.14, P = .25) and BCSS (HR = 1.72, 95% CI = 0.54-5.50, P = .357).Conclusion: Low stromal type I collagen mRNA and protein expression are associated with unfavourable tumour characteristics in breast cancer. Stromal type I collagen might predict chemotherapy response.
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| 5. |
- Svensson, Teresia, et al.
(författare)
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Influence of Multiple Environmental Factors on Organic Matter Chlorination in Podsol Soil
- 2017
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 51:24, s. 14114-14123
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Tidskriftsartikel (refereegranskat)abstract
- Natural chlorination of organic matter is common in soils. The abundance of chlorinated organic compounds frequently exceeds chloride in surface soils, and the ability to chlorinate soil organic matter (SOM) appears widespread among microorganisms. Yet, the environmental control of chlorination is unclear. Laboratory incubations with Cl-36 as a Cl tracer were performed to test how combinations of environmental factors, including levels of soil moisture, nitrate, chloride, and labile organic carbon, influenced chlorination of SOM from a boreal forest. Total chlorination was hampered by addition of nitrate or by nitrate in combination with water but enhanced by addition of chloride or most additions including labile organic matter (glucose and maltose). The greatest chlorination was observed after 15 days when nitrate and water were added together with labile organic matter. The effect that labile organic matter strongly stimulated the chlorination rates was confirmed by a second independent experiment showing higher stimulation at increased availability of labile organic matter. Our results highlight cause-effect links between chlorination and the studied environmental variables in podsol soil-with consistent stimulation by labile organic matter that did overrule the negative effects of nitrate.
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| 6. |
- Aanaes, K, et al.
(författare)
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Extensive Endoscopic Image-Guided Sinus Surgery Decreases BPI-ANCA in Patients with Cystic Fibrosis
- 2012
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Ingår i: Scandinavian Journal of Immunology. - : Blackwell Publishing. - 0300-9475 .- 1365-3083. ; 76:6, s. 573-579
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Tidskriftsartikel (refereegranskat)abstract
- Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa. The effect of surgery aiming to eradicate bacteria and infected tissue on BPI-ANCA levels is sparsely described. A cohort of patients with CF were included: 53 patients having extensive image-guided sinus surgery (EIGSS) with topical postoperative antibiotic treatment, 131 non-operated controls and 36 who had double lung transplantation (LTX). In all 219 patients, serum samples before and after surgery or at similar intervals were analysed for IgG and IgA BPI-ANCA. The EIGSS group showed a highly significant decrease in both IgA and IgG BPI-ANCA levels compared with their own preoperative values and control group values (P andlt; 0.0010.02). The LTX patients also showed a highly significant decrease in both IgA and IgG BPI-ANCA levels (P andlt; 0.001). EIGSS and LTX decrease IgA and IgG BPI-ANCA levels in patients with CF, indicating that extensive removal of infected tissue influences the pathogenic process of autoantibody production. The results shown herein are in favour of applying EIGSS in selected patients with CF and for using BPI-ANCA as a surrogate marker for guiding further therapeutic interventions.
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| 9. |
- Andersson, Eira, et al.
(författare)
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Breaking ore and gender patterns : a strategic and sustainable R&I-agenda for the Swedish mining industry
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish mining industry experiences a major production and economic boost and Luleå University of Technology (LTU) has established itself as Europe’s leading mining university. Together they are, along with other actors in society, a leading innovation system. This innovation system, however, face a number of challenges, such as recruitment problems, demand for new technology and research, mining communities that need be upgraded and restructured and unequal, gendered work, organizations and innovation policy initiatives.In this paper we present a gender aware research and innovation agenda in the mining sector, which aims to create more gender equal innovation and thus contribute to a socially sustainable and internationally competitive development of the Swedish mining sector. The agenda, a result of interactive collaboration between the project team, LTU mining researchers and actors from e.g. LKAB, Boliden AB, Northland resources as well as The County Council of Norrbotten and the local communities, contains a list of tentative projects, defined by the innovation system. Some examples of projects are; Key roles of middle management for a gender equal mining industry, Gender patterns among mining entrepreneur companies, Gender aware and strategic recruitment, promotion and retention practices in the mining industry and Attractive and gender equal mining communities. The long-¬‐term vision, defined by the innovation system, is that the Swedish mining industry is a field of excellence, that the industry is well known for being world-¬‐class at breaking ore and gender patterns, that gender aware organizations and workplace cultures are created and sustained for efficiency, productivity and innovation as well as that regions and communities are characterized by economic growth, openness, tolerance and collaboration between mining companies and society. Drawing on theories and reflections on “undoing gender”, “degendering” and “gender toning down” we will in the paper also introduce a discussion on the relations between global mining industry, work organizations (mining companies, entrepreneur companies), labour unions, other actors, surrounding local communities and regional context etc. when it comes to doing and constructions of masculinities.
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| 10. |
- Andersson, Elias, et al.
(författare)
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Constituting gender and gender equality through policy : the political of gender mainstreaming in the Swedish forest industry
- 2018
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Ingår i: Equality, Diversity and Inclusion. - : Emerald Group Publishing Limited. - 2040-7149 .- 2040-7157. ; 37:8, s. 763-779
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Tidskriftsartikel (refereegranskat)abstract
- PurposeIn Sweden, gender mainstreaming policies have a long political history. As part of the national gender equality strategy of the Swedish forest industry, the ten largest forestry companies committed themselves to gender mainstream their policies. Limiting the impact of policies and the agency of change, the purpose of this paper is to focus on the varied and conflicting meanings and constitution of the concepts, the problem and, in extent, the organisational realities of gender mainstreaming.Design/methodology/approachIn both, implementation and practice, gender mainstreaming posse challenges on various levels and by analysing these documents as practical texts from the WPR-approach. This paper explores constructions of gender and gender equality and their implications on the practice and the political of gender mainstreaming in a male-dominated primary industry.FindingsThe results show that the organisations themselves were not constituted as the subject of the policy but instead some of the individuals (women). The subject position of women represented in company policy was one of lacking skills and competences and in the need of help. Not only men and the masculine norms but organisational processes and structures were also generally invisible in the material. Power and conflict were mainly absent from the understanding of gender equality. Instead, consenting ideas of gender equality were the focus. Such conceptualisations of gender equality are beneficial for all risk concealing power structures and thereby limit the political space for change.Originality/valueBy highlighting the scale of policy and the significance of organisational contexts, the results indicate how gender and gender equality are constitutive through the governing technologies of neoliberal and market-oriented ideologies in policy – emphasising the further limiting of space for structural change and politicalization within the male-dominated organisations of Swedish forest industry.
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