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| 2. |
- Betancourt, Lazaro Hiram, et al.
(författare)
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The human melanoma proteome atlas-Defining the molecular pathology
- 2021
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Ingår i: Clinical and Translational Medicine. - : Wiley. - 2001-1326. ; 11:7, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.
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| 3. |
- Gyllensten, Ulf B., et al.
(författare)
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Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer
- 2022
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:7
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Tidskriftsartikel (refereegranskat)abstract
- Simple Summary Ovarian cancer is the eighth most common cancer among women and has a 5-year survival of only 30-50%. The survival is close to 90% for patients in stage I but only 20% for patients in stage IV. The presently available biomarkers have insufficient sensitivity and specificity for early detection and there is an urgent need to identify novel biomarkers. The aim of our study was to broadly measure protein biomarkers to find tests for the early detection of ovarian cancer. We found that combinations of 4-7 protein biomarkers can provide highly accurate detection of early- and late-stage ovarian cancer compared to benign conditions. The performance of the tests was then validated in a second independent cohort. Background: Ovarian cancer is the eighth most common cancer among women and has a 5-year survival of only 30-50%. The survival is close to 90% for patients in stage I but only 20% for patients in stage IV. The presently available biomarkers have insufficient sensitivity and specificity for early detection and there is an urgent need to identify novel biomarkers. Methods: We employed the Explore PEA technology for high-precision analysis of 1463 plasma proteins and conducted a discovery and replication study using two clinical cohorts of previously untreated patients with benign or malignant ovarian tumours (N = 111 and N = 37). Results: The discovery analysis identified 32 proteins that had significantly higher levels in malignant cases as compared to benign diagnoses, and for 28 of these, the association was replicated in the second cohort. Multivariate modelling identified three highly accurate models based on 4 to 7 proteins each for separating benign tumours from early-stage and/or late-stage ovarian cancers, all with AUCs above 0.96 in the replication cohort. We also developed a model for separating the early-stage from the late-stage achieving an AUC of 0.81 in the replication cohort. These models were based on eleven proteins in total (ALPP, CXCL8, DPY30, IL6, IL12, KRT19, PAEP, TSPAN1, SIGLEC5, VTCN1, and WFDC2), notably without MUCIN-16. The majority of the associated proteins have been connected to ovarian cancer but not identified as potential biomarkers. Conclusions: The results show the ability of using high-precision proteomics for the identification of novel plasma protein biomarker candidates for the early detection of ovarian cancer.
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- Hurtig, Oskar Nordlander, et al.
(författare)
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Drivers and Barriers to Deploy Microgrid in Sweden
- 2022
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Ingår i: IEEE PES Innovative Smart Grid Technologies Conference Europe. - 9781665480321 ; 2022-October
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Konferensbidrag (refereegranskat)abstract
- This paper aims to identify drivers and barriers of microgrid deployment in Sweden for gaining insights on the upscaling potential of microgrid adoption in the country. Furthermore, two real-life distribution grids in southern Sweden are used to dimension the energy storage system (ESS) needed to enable island operation of the grids through power balance analysis. The results have also shown the benefit of interconnecting two adjacent distribution grids to form an interconnected microgrid. Through interconnection, the size of ESS can be reduced by around 23% as compared to operating two microgrids separately on their own. The analysis has also shown a potential to further reduce the ESS size if the weather information is considered.
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| 6. |
- Lindberg, Catharina, et al.
(författare)
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The meaning of surviving three years after a heart transplant : a transition from uncertainty to acceptance through adaptation
- 2020
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:15
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Tidskriftsartikel (refereegranskat)abstract
- The rationale was to longitudinally follow-up interviews performed with heart recipients at their one-year examination in order to deepen the understanding of the meaning of surviving a heart transplant. The aim was to explore the meaning of surviving three years after a heart transplant compared to one year and to identify what constitutes the change process. A phenomenological–hermeneutic method was used. This multicenter study was carried out at the two hospitals in Sweden where heart transplants are performed. A total of 13 heart recipients who survived three years after a heart transplant were invited to participate in this three-year follow-up study and 12 accepted, 3 women and 9 men, with a mean age of 51.25 years. The naïve understanding revealed that the heart recipients strongly accepted their life situation and that time had enabled this acceptance of limitations through adaptation. The thematic structural analyses cover six themes illustrating the meaning of acceptance and adaptation, i.e., accepting life as it is, adapting to post-transplant limitations, adapting to a changed body, social adaptation, showing gratitude and trusting oneself and others. In conclusion, achieving acceptance and a solid sense of self-efficacy after heart transplantation is a time-consuming process that involves courage to face and accept the reality and adapt in every life dimension. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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| 7. |
- Lindberg, Matilda
(författare)
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Disciplinary literacy and verbal language in physical education
- 2024
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Ingår i: Sport, Education and Society. - : Routledge. - 1357-3322 .- 1470-1243.
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Tidskriftsartikel (refereegranskat)abstract
- Supporting pupils’ development regarding subject knowledge and disciplinary literacy is a complex and challenging task for teachers. Research shows that language-integrated physical education (PE) can assist children’s language development. However, it tends to reduce the time for physical activity, which is problematic since youth’s physical inactivity is a growing problem. This article examines how teachers can emphasize disciplinary literacy and stimulate pupils’ use of verbal language to enhance their learning in PE in a culturally and linguistically diverse context in Sweden. In this practice-based research study grounded in action research methodology, 20 ten-year-old pupils with culturally and linguistically diverse backgrounds participated with a teacher-researcher in 10 PE lessons in which disciplinary literacy and verbal language were intertwined with exploratory circus assignments. The theoretical framework is based on Biesta’s concept of risk. Data were collected through participant observation, video observation, interviews, and field diary. The data analysis was abductive, oscillating between the theory and the data. A thematic analysis was carried out. The results show that the exploratory circus assignments offered opportunities to emphasize disciplinary literacy and stimulate pupils’ use of verbal language. Focusing on language to ensure all pupils could partake and develop knowledge required time, which encroached on the pupils’ opportunity to be physically active. This was resolved through adding time before the PE lesson to activate the pupils’ background knowledge, anchor the language, and create pre-understanding. Further, including all pupils was challenging, and the pupils had different expectations regarding PE. The findings suggest that inviting pupils to speak involves an embedded risk in communication, but also carries dialogical potential. In collaboration with teaching colleagues, PE teachers can support and strengthen the pupils’ literacy development.
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| 8. |
- Lindberg, Matilda, et al.
(författare)
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How much circus is allowed? : Challenges and hindrances when embracing risk in physical education
- 2024
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Ingår i: Physical Education and Sport Pedagogy. - : Taylor & Francis. - 1740-8989 .- 1742-5786. ; 29:3, s. 245-258
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Research has indicated that Physical Education (PE) is often characterized by teacher-centred teaching (e.g. Byra 2006; Tinning 2010), where the pupils follow instruction and perform pre-established movements (Karlefors and Larsson 2018). Pupils are expected to listen, do as they are told, and follow rules (Fitzpatrick and Russell 2015; Quennerstedt 2013). PE teaching has been described as an act of control (Quennerstedt 2013), and teachers face the dilemma of letting go of control and still having enough control to make sure that the lesson smoothly moves forward (Alfrey and O'Connor 2020). However, when the pupils are given more power and the teacher applies student-centred teaching, the pupils get to come up with ideas and make decisions (e.g. Byra 2006; Garrett and Wrench 2018; Mattsson and Larsson 2021). This is significant because it can develop PE and contribute to meaning making among pupils and their experiences of movement. This article aims to analyse the use of exploratory circus assignments in PE teaching and to discuss this in relation to current school norms. Biesta's (The Beautiful Risk of Education [Paradigm Publishers 2014]) concept of risk, which means not knowing the outcome, is used. The article problematizes pupils' own ideas and suggestions in relation to prevailing norms in school. What happens when pupils participate in teaching based on exploratory circus assignments? Exploration, playfulness, and expression were focused, and the lessons were characterized by the absence of primary focus on competitiveness as a counterweight to traditional PE content. Methods: A research teacher (a university teacher with experience teaching school PE and circus) conducted 10 lessons together with 20 pupils (aged 10) and their PE teacher using exploratory circus assignments. Data was collected through participant observation, video observation, and field diary. The data analysis generated three themes, Following instruction, Limited exploration, and Shared power, that were reviewed in relation to the theoretical framework. Results: The results show that the research teacher and the PE teacher resisted embracing risk in PE due to the prevailing norms and what Biesta (2014) describes as the practice of schooling. They focused on keeping the pupils in order rather than being flexible and open to unknown outcomes. The exploratory circus assignments involved risk to different extents, and the research teacher's tendency to embrace risk increased over time. Her letting go of control enabled her to embrace risk. It did not mean a total relinquishment of control, but rather not having exclusive control over the decision-making and meaning-making processes. When she shared the power with the pupils, new and other movements could be explored. The results show that pupils' actions can be more educative than what teachers initially consider. Conclusion: Teachers need to relinquish control to conduct teaching which embraces risk. Doing so enables them to share power with the pupils, which allows pupils to explore and discover different ways of moving and using the material. Exploratory circus assignments can enable risk embracement in PE and function as a way for teachers to reflect upon pedagogical considerations and practice the sharing of power with their pupils.
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| 9. |
- Lindberg, Matilda, et al.
(författare)
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“It’s fun but at the same time difficult” : Experiences of and perspectives on children’s participation in decision-making processes in Physical Education and Health
- 2021
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Ingår i: Forskning og Forandring. - : Cappelen Damm Akademisk. - 2535-5279. ; 4:2, s. 128-147
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Tidskriftsartikel (refereegranskat)abstract
- Swedish compulsory school education rests upon the foundation of democracy, and the Curriculum for the compulsory school, preschool class and school-age educare 2011 (Skolverket, 2018) stresses that children should have the opportunity to take initiatives. Research shows that children are not able to have any influence on activities in Physical Education and Health (PEH). Usually, they have to follow the teacher’s instructions and reproduce specific movement patterns. This article discusses a research project that challenged traditional ways of teaching PEH, in order to give 10-year-old children the opportunity to have an influence on PEH. The project involved 10 circus lessons in which the children were encouraged to explore movement and put their own ideas into practice. In terms of theory, the approach is based on Hart’s (1997) Ladder of Children’s Participation. Data were collected through participant observations, video observations, interviews, and a field diary. The results show that the children participated in varying degrees and experienced attempts to increase their influence in different ways: Some found it fun and free, while others found it difficult and boring. One important conclusion is that influence and participation need to be practised – both by children and by teachers. Circus activities, because of the playfulness and creativity involved, may be very suited to practising influence and participation.
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| 10. |
- Moreno Berggren, Daniel, et al.
(författare)
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Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia : a nationwide population-based study
- 2021
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Ingår i: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 192:3, s. 474-483
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Tidskriftsartikel (refereegranskat)abstract
- Outcomes in chronic myelomonocytic leukaemia (CMML) are highly variable and may be affected by comorbidity. Therefore, prognostic models and comorbidity indices are important tools to estimate survival and to guide clinicians in individualising treatment. In this nationwide population-based study, we assess comorbidities and for the first time validate comorbidity indices in CMML. We also compare the prognostic power of: the revised International Prognostic Scoring System (IPSS-R), CMML-specific prognostic scoring system (CPSS), MD Anderson Prognostic Scoring System (MDAPS) and Mayo score. In this cohort of 337 patients with CMML, diagnosed between 2009 and 2015, the median overall survival was 21 center dot 3 months. Autoimmune conditions were present in 25% of the patients, with polymyalgia rheumatica and Hashimoto's thyroiditis being most common. Of the tested comorbidity indices: the Charlson Comorbidity Index (CCI), Haematopoietic cell transplantation-specific Comorbidity Index (HCT-CI) and Myelodysplastic Syndrome-Specific Comorbidity Index (MDS-CI), CCI had the highest C-index (0 center dot 62) and was the only comorbidity index independently associated with survival in multivariable analyses. When comparing the prognostic power of the scoring systems, the CPSS had the highest C-index (0 center dot 69). In conclusion, using 'real-world' data we found that the CCI and CPSS have the best prognostic power and that autoimmune conditions are overrepresented in CMML.
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