| 1. |
- Semb, Gunvor, et al.
(författare)
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A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
- 2017
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Ingår i: Journal of Plastic Surgery and Hand Surgery. - : Taylor & Francis. - 2000-656X .- 2000-6764. ; 51:1, s. 2-13
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed. This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP). It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project.METHOD: Ten established national or regional cleft centres participated. Lip and soft palate closure at 3-4 months, and hard palate closure at 12 months served as a common method in each trial. Trial 1 compared this with hard palate closure at 36 months. Trial 2 compared it with lip closure at 3-4 months and hard and soft palate closure at 12 months. Trial 3 compared it with lip and hard palate closure at 3-4 months and soft palate closure at 12 months. The primary outcomes were speech and dentofacial development, with a series of perioperative and longer-term secondary outcomes.RESULTS: Recruitment of 448 infants took place over a 9-year period, with 99.8% subsequent retention at 5 years.CONCLUSION: The series of reports that follow this introductory paper include comparisons at age 5 of surgical outcomes, speech outcomes, measures of dentofacial development and appearance, and parental satisfaction. The outcomes recorded and the numbers analysed for each outcome and time point are described in the series.TRIAL REGISTRATION: ISRCTN29932826.
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| 2. |
- Angdal, Henrik, et al.
(författare)
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Trends in Service Sourcing Practices
- 2007
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Ingår i: Journal of Business Market Management. - : Springer Science and Business Media LLC. - 1864-0753 .- 1864-0761. ; 1:3, s. 187-207
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Diaz-Morales, Oscar, et al.
(författare)
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Catalytic effects of molybdate and chromate–molybdate films deposited on platinum for efficient hydrogen evolution
- 2023
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Ingår i: Journal of chemical technology and biotechnology (1986). - : Wiley. - 0268-2575 .- 1097-4660. ; 98:5, s. 1269-1278
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Sodium chlorate (NaClO3) is extensively used in the paper industry, but its production uses strictly regulated highly toxic Na2Cr2O7 to reach high hydrogen evolution reaction (HER) Faradaic efficiencies. It is therefore important to find alternatives either to replace Na2Cr2O7 or reduce its concentration.RESULTS: The Na2Cr2O7 concentration can be significantly reduced by using Na2MoO4 as an electrolyte co-additive. Na2MoO4 in the millimolar range shifts the platinum cathode potential to less negative values due to an activating effect of cathodically deposited Mo species. It also acts as a stabilizer of the electrodeposited chromium hydroxide but has a minor effect on the HER Faradaic efficiency. X-ray photoelectron spectroscopy (XPS) results show cathodic deposition of molybdenum of different oxidation states, depending on deposition conditions. Once Na2Cr2O7 was present, molybdenum was not detected by XPS, as it is likely that only trace levels were deposited. Using electrochemical measurements and mass spectrometry we quantitatively monitored H2 and O2 production rates. The results indicate that 3 μmol L−1 Na2Cr2O7 (contrary to current industrial 10–30 mmol L−1) is sufficient to enhance the HER Faradaic efficiency on platinum by 15%, and by co-adding 10 mmol L−1 Na2MoO4 the cathode is activated while avoiding detrimental O2 generation from chemical and electrochemical reactions. Higher concentrations of Na2MoO4 led to increased oxygen production.CONCLUSION: Careful tuning of the molybdate concentration can enhance performance of the chlorate process using chromate in the micromolar range. These insights could be also exploited in the efficient hydrogen generation by photocatalytic water splitting and in the remediation of industrial wastewater.
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| 4. |
- Field, James, et al.
(författare)
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Embedding environmental sustainability within oral health professional curricula-Recommendations for teaching and assessment of learning outcomes.
- 2023
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Ingår i: European journal of dental education. - : John Wiley & Sons. - 1396-5883 .- 1600-0579. ; 27:3, s. 650-661
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The FDI World Dental Federation suggests that "dentistry, as a profession, should integrate Sustainable Development Goals into daily practice and support a shift to a green economy in the pursuit of healthy lives and wellbeing for all, through all stages of life." This article reports on the recent activity of the Association for Dental Education in Europe Special Interest Group for Sustainability in Dentistry. Following on from the group's previous activities, which explored current educational practice, this work aimed to reach a pan-European consensus on a number of learning outcomes for environmental sustainability, in order to (i) support institutions in designing and delivering their curriculum, and (ii) to further harmonise the delivery of oral health professional education across Europe. This article presents specific learning outcomes relating to environmental sustainability and recommendations relating to curriculum development, including methods of teaching and assessment.
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| 5. |
- Furusten, Staffan, et al.
(författare)
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Breaking Laws - Making Deals : Procurement of management consultants in the public sector
- 2005. - 1st Edition
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Ingår i: Dealing with Confidence: The Construction of Need and Trust in Management Advisory Services. - Frederiksberg : Copenhagen Business School Press. - 9788763099660 - 8763099667 - 9788763099660 - 8763099667 ; , s. 169-183
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In the previous chapter, we saw that an important characteristic of large corporations in the purchasing top management consultancies was that they tend to base their purchasing decisions on the reputation of the consultancy and earlier personal experience of the consultancy. As shown in Furusten (2003), reputation and previous assignments are also seen as important by management consultants in how they look upon their relations to potential buyers of their services. Working close to potential buyers, and assisting them in their definitions of problems and need for services are seen by many consultants as crucial strategies, not only to do business, but also to be able to deliver professional services. Against this background, it is very interesting to focus on public organizations' purchasing of management consulting services since these organizations have to play by strict government rules when purchasing everything, management consulting services included.
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| 6. |
- Gullberg, Maria, et al.
(författare)
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A single coxsackievirus B2 capsid residue controls cytolysis and apoptosis in rhabdomyosarcoma cells.
- 2010
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Ingår i: Journal of Virology. - 0022-538X .- 1098-5514. ; 84:12, s. 5868-5879
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Tidskriftsartikel (refereegranskat)abstract
- Coxsackievirus B2 (CVB2), one of six human pathogens of the group B coxsackieviruses within the enterovirus genus of Picornaviridae, causes a wide spectrum of human diseases ranging from mild upper respiratory illnesses to myocarditis and meningitis. The CVB2 prototype strain Ohio-1 (CVB2O) was originally isolated from a patient with summer grippe in the 1950s. Later on, CVB2O was adapted to cytolytic replication in rhabdomyosarcoma (RD) cells. Here, we present analyses of the correlation between the adaptive mutations of this RD variant and the cytolytic infection in RD cells. Using reverse genetics, we identified a single amino acid change within the exposed region of the VP1 protein (glutamine to lysine at position 164) as the determinant for the acquired cytolytic trait. Moreover, this cytolytic virus induced apoptosis, including caspase activation and DNA degradation, in RD cells. These findings contribute to our understanding of the host cell adaptation process of CVB2O and provide a valuable tool for further studies of virus-host interactions.
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| 7. |
- Gullberg, Maria, et al.
(författare)
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Characterization of a putative ancestor of coxsackievirus B5.
- 2010
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Ingår i: Journal of Virology. - 0022-538X .- 1098-5514. ; 84, s. 9695-9708
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Tidskriftsartikel (refereegranskat)abstract
- Like other RNA viruses, coxsackievirus B5 (CVB5) exists as circulating heterogeneous populations of genetic variants. In this study, we present the reconstruction and characterization of a probable ancestral virion of CVB5. Phylogenetic analyses based on capsid protein encoding regions (the VP1 gene of 41 clinical isolates and the entire P1 region of eight clinical isolates) of CVB5 revealed two major co-circulating lineages. Ancestral capsid sequences were inferred from sequences of these contemporary CVB5 isolates using maximum likelihood methods. By using Bayesian phylodynamic analysis, the inferred VP1 ancestral sequence was dated back to 1854 (1807-1898). In order to study the properties of the putative ancestral capsid, the entire ancestral P1 sequence was synthesized de novo and inserted into the replicative backbone of an infectious CVB5 cDNA clone. Characterization of the recombinant virus in cell culture showed that fully functional infectious virus particles were assembled and that these viruses displayed properties similar to those of modern isolates, in terms of receptor preferences, plaque phenotype, growth characteristics and cell tropism. This is the first report describing resurrection and characterization of a picornavirus with a putative ancestral capsid. Our approach, including phylogenetics-based reconstruction of viral predecessors, could serve as a starting point for experimental studies of viral evolution and might also provide an alternative strategy in the development of vaccines.
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| 8. |
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| 9. |
- Gummesson, Christina, et al.
(författare)
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The Use Of Meta-Ethnography To Guide Implementation Strategies
- 2022
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundFor implementation of new assessment strategies, an evidence-informed approach is desired. Thus, the assessment method should be supported by current evidence, and similarly the implementation process could be informed through research. Implementation research can be done using various approaches and research methods. However, it seems that interview studies are an important source of information. To utilize previous qualitative information, one may simply read the papers to be informed by each individual study. However, another approach may be to search the literature systematically and analyse the qualitative information as a data source. Several ways of conducting literature reviews are available, but it seems that the analysis of qualitative studies is less common. In this presentation we would like to present how meta-ethnography can be used as a method to develop knowledge on the implementation of e-portfolio.Summary of workMeta-ethnography is a systematic literature review through seven steps described by Noblit and Hare (1988), and further elaborated on by Britten et al (2002) and France et al (2019), in brief consisting of a systematic review, a stepwise qualitative analysis and synthesis. Four different databases were used for our literature search.Summary of resultsThrough the seven steps, we analyzed the data both from “first order information” (published quotations) and “second order information” (researchers’ interpretation, analysis, and discussion) to reach a “third order interpretation” (our synthesis). We will present the steps and our findings, using our search on implementation of e-portfolio in dental education as a model. Our analysis and synthesis yielded two main themes and five sub-themes with aspects important to consider when implementing e-portfolio.Discussion, Conclusion & Take-Home MessageWe found meta-ethnography to broaden our knowledgebase beyond each separate study and believe it could add to the understanding of other aspects of assessment as well, in areas where primary studies are using qualitative methods.ReferencesNoblit, G.W., et al., Meta-Ethnography: Synthesizing Qualitative Studies. 1988: SAGE Publications.Britten, N., et al., Using meta ethnography to synthesise qualitative research: a worked example. J Health Serv Res Policy, 2002. 7(4): p. 209-15.France, E.F., et al., Improving reporting of meta-ethnography: the eMERGe reporting guidance. BMC Medical Research Methodology, 2019. 19(1): p. 25.
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| 10. |
- Hellström, Nina, 1976, et al.
(författare)
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Unique gene expression patterns indicate microglial contribution to neural stem cell recovery following irradiation.
- 2011
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Ingår i: Molecular and cellular neurosciences. - : Elsevier BV. - 1095-9327 .- 1044-7431. ; 46:4, s. 710-9
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Tidskriftsartikel (refereegranskat)abstract
- Ionizing radiation results in damage to neural stem cells and reduced neurogenesis. The aim of the present study was to determine intrinsic and extrinsic factors that influence neural stem cell survival following irradiation, using qPCR. Gene expression of hippocampal and SVZ neurospheres were analyzed following irradiation, and results demonstrated that irradiated hippocampal and SVZ stem cells displayed similar gene expression profiles for intrinsic genes. Irradiated microglia (extrinsic factor) isolated from the SVZ exhibited increased gene expression of growth factors involved in stem cell maintenance, proliferation, and survival. However, microglial genes in the irradiated hippocampus responded less favorably with respect to stem cell recovery. This might explain the superior recovery of SVZ compared to hippocampal stem cells following in vivo irradiation. In addition, our results show that a combination of growth factors, which were upregulated in SVZ microglia, increased the proliferation and decreased cell death of irradiated neurospheres in vitro.
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