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| 2. |
- Abramsson, Alexandra, 1973, et al.
(författare)
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Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
- 2007
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Ingår i: GENES & DEVELOPMENT. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 21:3, s. 316-331
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Tidskriftsartikel (refereegranskat)abstract
- During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF-BB function during vascular development. We studied the participation of HS chains in pericyte recruitment using two mouse models with altered HS biosynthesis. Reduction of N-sulfation due to deficiency in N-deacetylase/N-sulfotransferase-1 attenuated PDGF-BB binding in vitro, and led to pericyte detachment and delayed pericyte migration in vivo. Reduced N-sulfation also impaired PDGF-BB signaling and directed cell migration, but not proliferation. In contrast, HS from glucuronyl C5-epimerase mutants, which is extensively N- and 6-O-sulfated, but lacks 2-O-sulfated L-iduronic acid residues, retained PDGF-BB in vitro, and pericyte recruitment in vivo was only transiently delayed. These observations were supported by in vitro characterization of the structural features in HS important for PDGF-BB binding. We conclude that pericyte recruitment requires HS with sufficiently extended and appropriately spaced N-sulfated domains to retain PDGF-BB and activate PDGF receptor β (PDGFRβ) signaling, whereas the detailed sequence of monosaccharide and sulfate residues does not appear to be important for this interaction.
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| 4. |
- Basu Bal, Abhinayan, 1980, et al.
(författare)
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Different Perspectives on Supply Chain Finance – In search of a holistic approach
- 2017
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Ingår i: PLAN’s Research and Application Conference, 25-26 October, Gothenburg.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper discusses from a logistics services, financial and legal standpoint the possibility to deliver SCF solutions to the entire supply chain. Particularly the potential new role of LSPs as independent third parties that can assist in verification and risk assessment for trade financiers or add supply chain finance to the service portfolio. Based on a conceptual model defining supply chain finance and financial supply chain management, the research approach includes conceptual development complemented by financial and legal analysis. The findings in the areas of information asymmetry, visibility, working capital and division of roles can foster innovation in the financial technology arena for greater financial inclusion in international trade.
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| 5. |
- Basu Bal, Abhinayan, 1980, et al.
(författare)
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Different Perspectives on Supply Chain Finance – In search of a holistic approach
- 2018
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Ingår i: Gong, S., Cullinane, K., (Eds.) Finance and Risk Management for International Logistics and the Supply Chain, 1st Edition. - Oxford : Elsevier. - 9780128138304 ; , s. 35-54
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Bokkapitel (refereegranskat)abstract
- This chapter discusses from a logistics services, financial and legal standpoint the possibility to deliver Supply Chain Finance (SCF) solutions to the entire supply chain. Particularly the potential new role of Logistics Service Providers (LSPs) as independent third parties that can assist in verification and risk assessment for trade financiers or add SCF to the service portfolio. Based on a conceptual model defining SCF and financial supply chain management, the research approach includes conceptual development complemented by financial and legal analysis. The findings in the areas of information asymmetry, visibility, working capital and division of roles can foster innovation in the financial technology arena for greater financial inclusion in international trade.
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- Ben-Menachem, Gil, et al.
(författare)
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The physico-chemical characteristics of the phosphocholine-containing glycoglycerolipid MfGL-II govern the permeability properties of Mycoplasma fermentans
- 2001
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Ingår i: The FEBS Journal, European Journal of Biochemistry. - : Wiley. ; 268:13, s. 3694-3701
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Tidskriftsartikel (refereegranskat)abstract
- Mycoplasma fermentans seems to be involved in several pathogenic condtions in humans, and is among other things capable of fusing with T-cells and lymphocytes. The choline-containing phosphoglycolipid 6'-O-(3"-phosphocholine-2"-amino-1"-phospho-1",3"-propanediol)-α-d-glucopyranosyl-(1'→3)-1,2-diacylglycerol (MfGL-II) in the membrane of M. fermentans has been suggested to enhance the fusion process, and the characteristics of MfGL-II were therefore investigated. When a cell culture ages the fraction of MfGL-II increases, and the fraction of the other major membrane lipid, phosphatidylglycerol (PtdGro), decreases concomitantly. Swelling experiments showed that the permeability and osmotic fragility are markedly reduced in aged cells. MfGL-II is selectively released into the surrounding medium when aged M. fermentans cells are incubated in buffer containing EDTA. The physico-chemical properties of MfGL-II were studied by NMR spectroscopy and differential scanning calorimetry, and they can explain the biochemical results. The temperature for the transition between gel and lamellar liquid crystalline (Lα) phases is 35–45 °C higher for MfGL-II than for PtdGro, which most probably gives rise to the reduced permeability in aged cells. At high water contents MfGL-II forms an Lα phase and isotropic aggregates which were interpreted to be vesicles with a radius of ≈ 450 Å. It is proposed that MfGL-II forms vesicles in the surrounding medium when it is released from the cell membrane. Neither EDTA nor Ca2+ ions have a significant influence on the aggregate structures formed by MfGL-II. Our results indicate that MfGL-II has no fusogenic properties. It is more probable that a recently identified lysolipid in the M. fermentans membrane acts as a fusogen.
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| 7. |
- Bergendahl, Göran, 1940, et al.
(författare)
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Duration Analysis – An Exposé
- 2009
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Ingår i: Wolpertinger Conference 2009, European Association of University Teachers of Banking and Finance, Sept 2-5, Rome, Italy.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Asset and Liability Management (ALM) is usually viewed as the principles and the practice to control movements in the market interest rates. Up to present time these techniques have been used mainly to protect the balance sheet. Today, a focus is also set on how economic value is created in banks and other financial institutions. In this context Duration Analysis is a method for risk management with a focus on strategies for immunization. The purpose of this paper is to give an exposé over the use of the concept duration not only in banking and finance but in some other sectors as well. In 1938 Macaulay introduced duration as a method to estimate how a change in interest rate had influence on the value of a bond. Later on duration has been introduced as a method to determine the effect a change in interest rates has on a life insurance firm. Nowadays one may find a wider use of duration analysis in other sectors such as the management of energy production, the management of customer loyalty, and the management of survival issues. This paper will give an exposé over different methods of duration analysis. It will also demonstrate how methods of this kind may be applied to risk management in different sectors with a certain emphasis on banking, insurance and energy.
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| 8. |
- Bergendahl, Göran, 1940, et al.
(författare)
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Duration Analysis: An Overview
- 2010
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Ingår i: New issues in Financial and Credit Markets. - Hampshire England : Palgrave Macmillan. - 9780230275447 ; , s. 171-183
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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