| 1. |
- Lundholm, Carl, et al.
(författare)
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A randomized prospective study comparing long-term intravesical instillations of mitomycin-c and BCG in patients with superficial bladder carcinoma
- 1996
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Ingår i: Journal of Urology. - 0022-5347 .- 1527-3792. ; 156:2, s. 372-376
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: We compared the efficacy and toxicity of long-term mitomycin C versus bacillus Calmette-Guerin (BCG) instillation in patients at high risk for recurrence and progression of superficial bladder carcinoma. MATERIALS AND METHODS: Our randomized comparison study included 261 patients with primary dysplasia, or stage Tis, stage T1, grade 3 and multiple recurrent stage Ta/T1, grade 1 or 2 disease. Mitomycin C (40 mg.) or Pasteur strain BCG (120 mg.) was instilled weekly for 6 weeks, then monthly for up to 1 year and every 3 months during year 2. RESULTS: After a median followup of 39 months 49% of the patients given BCG and 34% given mitomycin C were disease-free (p < 0.03), compared to 48 and 35%, respectively, of those with stage Ta or T1 disease, and 54 and 33%, respectively, of those with dysplasia or stage Tis tumor. Tumor progressed in 13% of patients, with no statistically significant difference observed regarding progression between the mitomycin C and BCG groups. Side effects were more common after BCG instillation, with 5 cases of severe side effects compared to 1 in the mitomycin C group. Treatment was stopped due to toxicity in 10% of the patients. CONCLUSIONS: The majority of patients tolerated long-term intravesical therapy well. BCG instillation was hampered by more frequent side effects. BCG was superior regarding recurrence prophylaxis, since patients given BCG had fewer recurrences and a significantly longer time to treatment failure compared to those treated with mitomycin C. No statistically significant difference was observed regarding progression.
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| 2. |
- Ronquist, Gunnar, et al.
(författare)
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Captopril may reduce biochemical (prostate-specific antigen) failure following radical prostatectomy for clinically localized prostate cancer
- 2009
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 43:1, s. 32-36
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A prior report suggested that individuals medicated with captopril showed a decreased incidence of prostate cancer. This study therefore investigated whether captopril given postoperatively had any preventive effect on biochemical recurrence for patients treated with radical prostatectomy. MATERIAL AND METHODS: Data were prospectively reviewed for 62 men subjected to radical retropubic prostatectomy due to biopsy-confirmed, clinically localized prostate cancer and comparisons were made between two groups, those receiving captopril postoperatively (12.5 mg twice daily; captopril group, n=32) and those not receiving any captopril (control group, n=30). One surgeon carried out the surgery. RESULTS: The two groups were comparable as regards age at surgery, prostate volume, preoperative prostate-specific antigen values, pathological stage, Gleason score, organ-confined disease, occurrence of positive surgical margins and extraprostatic extension. The incidence of biochemical failure was three out of 32 patients in the captopril group and 10 out of 30 in the control group (p=0.034) during a mean observational time of 29 months. CONCLUSIONS: A lower rate of biochemical recurrence was observed in men subjected to radical prostatectomy treated with captopril postoperatively than in those not receiving captopril. These results were based on only 32 observations; a larger study may show no evidence of an association.
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| 3. |
- Wik, Torsten, 1968, et al.
(författare)
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Modelling the Dynamics of a Trickling Filter for Waste Water Treatment
- 1994
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Ingår i: Proceedings of the Third IEEE Conference on Control Applications, 1994. ; 2, s. 1035 - 1040
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Konferensbidrag (refereegranskat)abstract
- This study concerns the dynamics of the nitrifying efficiency of a trickling filter for waste water treatment. In a novel approach, based on minimum plant area usage, a filter will be placed after the secondary sedimentation tanks with recirculation to the activated sludge process stage. The objective of the trickling filter model is to describe the growth of the nitrifying bacteria Nitrosomonas and Nitrobacter in the bio-film. A steady state mass-balance model for the substrates in the film based on Monod kinetics has been formulated. The dynamics of the filter, or the “memory”, is described by a division of the film in four volume fractions, Nitrosomonas, Nitrobacter, inert (non-active) material and water. These fractions are calculated at different depths of the film as well as for various layers of the filter structure. Data from a pilot plant at Rya treatment plant in Gothenburg, Sweden, have provided the necessary feedback for calculating model parameters, verifying assumptions etc. A shooting and matching routine in the NAG Fortran library is used for the solution of the model equations. Simulations performed so far have indicated that it can take days and even weeks for changes in the bacteria populations to take place. This means that the working point for the proposed full scale filter at the plant should track the past history of the filter
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| 4. |
- Wik, Torsten, 1968, et al.
(författare)
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Modelling the Dynamics of a Trickling Filter for Waste Water Treatment
- 1994
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Ingår i: Preprints of the 5th Nordic Process Control Workshop, Lyngby, Denmark.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This study concems the dynamics of the nitrifying efficiency of a trickling filter for waste water treatment. In a novel approach, based on minimum plant area usage, a filter will be placed after the secondary sedimentation tanks with recirculation to the activated sludge process stage. The objective of the trickling filter model is to describethe growth of the nitrifying bacteria Nitrosomonas and Nitrobacter in the bio-film. A steady state mass-balance model for the substrates in the film based on Monod kinetics has been formulated. The dynamics of the filter, or the “memory”, is described by a division of the film infour volume fractions, Nitrosomonas, Nitrobacter, inert (non-active) material and water. These fractions are calculated at different depths of the film as well as for various layers of the filter StrUCtUTe. Data from a pilot plant at Rya treatment plant in Gothenburg, Sweden, haveprovided the necessary feedback for calculating model parameters, verifying assumptions etc. A shooting and matching routine in the NAG Fortran library is used for the solution of the model equations. Simulations performed so far have indicated that it can take days and even weeks for changes in the bacteria populations to take place. Thismeans that the working point for the proposed full scale filter at the plant should track the past history of the filter.
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