| 1. |
- Mispelaere, Jan, 1965-
(författare)
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Guldmynt eller äpple : Straffrättsligt ansvar för barn och ungdomar i Sverige och Nederländerna 1590-1800
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The principal aim of this dissertation was to examine the character in praxis of children's and youth's criminal responsibility in two particular European regions during the early modern period that, in comparison with each other, were marked by a number of substantial societal differences. The regions selected were the densely populated, market-oriented coastal district of the Netherlands and the sparsely populated agricultural society in Sweden during the period 1590-1800.Since there were substantial economic and social differences between the Netherlands and Sweden during the 1600s in such areas as the development of salaried work, urbanization, and the structure and character of the household, it was reasonable to imagine that the present investigation would reveal, among other things, that there were marked differences in views concerning children and youth as well. Upon the basis of what was written concerning the application of extenuating circumstances in respect to children, along with what was known about views concerning children in older legislation, previous research has emphasized that there were a considerable number of similarities within European legal praxis during the early modern period.In conclusion, one can state that early modern judges from the Netherlands and Sweden assigned criminal responsibility to children under twelve in quite similar ways, while the differences between them in this regard primarily concerned how youths were treated. There was roughly the same attitude concerning children throughout the period 1590-1799 in both regions, but the view concerning the criminal responsibility of teenagers was different in the Netherlands until the first half of the 1700s. Views concerning their criminal responsibility were quite clearly influenced by such factors as gender, competence, and age, but the effect of social changes was to a much greater degree visible in praxis for them than it was in respect to children under twelve. Different societies placed different demands on youths, and this was expressed above all in the age level for full responsibility and the application of adult punishment.The most striking differences between the Netherlands and Sweden concerned the application of age limits for full responsibility, the responsibility borne by youths who had been enticed into committing crimes, and the manner in which the law viewed the responsibility of boys and girls when the offenders were between twelve and eighteen years of age. All three of the most substantial differences thus involved the level of criminal responsibility that youths bore.
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| 2. |
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| 3. |
- Aronsson, August, 1980-
(författare)
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Löfte, tvist och försoning : Politikens spelregler i 1300-talets Norden
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis aims to explain how politics in 14th century Scandinavia were structured by a set of rules or norms of conduct – rules which were neither codified nor enforced by any outside agency, yet had a very real impact on the patterns by which political action was conducted. Taking inspiration from historical anthropology, the study sets out to analyze the ways in which political tensions and relationships, primarily within the royal elite, were negotiated in various situations. The source material – mainly letters of treaties, but also contemporary literary sources – are treated as remains of political communication within a common discursive framework.The findings of the study go against some established notions about politics in the 14th century that are prevalent in current Scandinavian research. On the whole, patterns of political behaviour during the period show great similarities to those of the earlier Middle Ages, despite the discontinuity implied by the idea of the 13th century as the era of "state formation" in Scandinavia. Rather, the kings and princes of the 14th century appear to have been ruled by quite similar norms of behaviour to those of their predecessors, albeit on a more complex scale.The concepts of peace and justice are shown to have been central to the way that political action was legitimized. No functional difference can be shown to have been made between "feudal" or personal relations, and those of the state. Peace was conceived as a state of harmony, which could only be achieved through the establishment of mutual positive bonds, and an active striving for justice. The latter was achieved, both with the aid of mediators and negotiators, and through the demonstration of force, in patterns largely similar to the practice of feuding. Likewise, acts of supplication and reconciliation are shown to have played an active part in the way that political relations were reified during the process of ending an armed conflict.
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| 4. |
- Axelsson, Erik
(författare)
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Historien i politiken : Historieanvändning i norsk och svensk EU-debatt 1990-1994
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this dissertation the use of history in public debate in Norway and Sweden in relation to membership in the European Union (EU) 1990–1994 is examined. The purpose is to contribute with new knowledge about the relationship between politics and writing history, as well as describe the role of history in national and other identities. The analysis is both quantitative and qualitative. Historical narratives are re-constructed from the history used by the political figures when they argued for or against EU membership. The narratives relate to the political subjects which were in the limelight in connection with the question of EU, as well as preconceptions about Norwegian, Swedish and European identity. The dissertation shows that history is a multifaceted rhetorical tool in the political debate. In Sweden it was the policy of national security which was debated from a historical perspective. In it the debaters also used several examples from European history. In Norway, history entered the debate in connection with issues relating to sovereignty and democracy. In comparison with the Swedish EU debate, European history was drawn on less in Norway. Historical narratives of identity appearing in the EU debate show structural similarities, but at the same time differ in significant aspects. In a comparison the Norwegian national narrative seems unequivocal and well defined. It is retrospective due to its main component being the development of democracy in 19th century Norway. The Swedish national narrative is very clearly based on a notion of progress and continuous development, both as regards economy and democracy, and it is the history of the 20th century which stands in focus. In Sweden the constructions of the past separated according to party political lines, and the content of the national narrative was very much subject to debate.
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| 5. |
- Berglund, Louise, 1966-
(författare)
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Guds stat och maktens villkor : Politiska ideal i Vadstena kloster, ca 1370-1470
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Vadstena abbey was one of the most powerful religious institutions of Sweden in the Middle Ages. This thesis analyses two specific aspects of this position: the position of Vadstena abbey as an agent in the political space of the late Middle Ages, and the political ideals propagated by that institution.Sermons written for the feast days of Nordic saints constitute the central source material for this study. Sermons were the most efficient mass media of the medieval world and at an institution like Vadstena, preachers could hope to reach thousands of people from all social groups. Using the sermons I have analysed the political ideals propagated by the abbey. In the beginning of the period, the abbey taught an ideal close to that of Bernard of Clairvaux, an ideology of the supremacy of religious institutions over temporal ones, the priests as the lights of society and the unique authority of saint Birgitta. They berated the temporal powers for not following the dictates of the church and maintained that such behaviour would lead to ruin. Towards the middle of the 15th century a significant change occurred. The brothers began to teach that an evil king and tyrant was still legitimate, since his misrule was part of God’s plan.This change in the political ideals is related to a change in the position of the abbey in relation to temporal powers. After being relatively autonomous the abbey gradually became less so. This, I argue, is due to the strengthening of the institution of monarchy during a period otherwise seen as simply chaotic.
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| 6. |
- Bäck, Tom, 1964, et al.
(författare)
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Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors
- 2020
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Ingår i: Ejnmmi Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Targeted alpha therapy (TAT) is a promising treatment for micrometastatic and minimal residual cancer. We evaluated systemic alpha-radioimmunotherapy (alpha-RIT) of metastatic castration-resistant prostate cancer (mCRPC) using the alpha-particle emitter At-211-labeled to the anti-PSCA A11 minibody. A11 is specific for prostate stem cell antigen (PSCA), a cell surface glycoprotein which is overexpressed in more than 90% of both localized prostate cancer and bone metastases. Methods PC3-PSCA cells were implanted subcutaneously (s.c.) and intratibially (i.t) in nude mice. Efficacy of alpha-RIT (two fractions-14-day interval) was studied on s.c. macrotumors (0, 1.5 and 1.9 MBq) and on i.t. microtumors (100-200 mu m; 0, 0.8 or 1.5 MBq) by tumor-volume measurements. The injected activities for therapies were estimated from separate biodistribution and myelotoxicity studies. Results Tumor targeting of At-211-A11 was efficient and the effect on s.c. macrotumors was strong and dose-dependent. At 6 weeks, the mean tumor volumes for the treated groups, compared with controls, were reduced by approximately 85%. The separate myelotoxicity study following one single fraction showed reduced white blood cells (WBC) for all treated groups on day 6 after treatment. For the 0.8 and 1.5 MBq, the WBC reductions were transient and followed by recovery at day 13. For 2.4 MBq, a clear toxicity was observed and the mice were sacrificed on day 7. In the long-term follow-up of the 0.8 and 1.5 MBq-groups, blood counts on day 252 were normal and no signs of radiotoxicity observed. Efficacy on i.t. microtumors was evaluated in two experiments. In experiment 1, the tumor-free fraction (TFF) was 95% for both treated groups and significantly different (p < 0.05) from the controls at a TFF of 66%). In experiment 2, the difference in TFF was smaller, 32% for the treated group versus 20% for the controls. However, the difference in microtumor volume in experiment 2 was highly significant, 0.010 +/- 0.003 mm(3) versus 3.79 +/- 1.24 mm(3) (treated versus controls, respectively), i.e., a 99.7% reduction (p < 0.001). The different outcome in experiment 1 and 2 is most likely due to differences in microtumor sizes at therapy, or higher tumor-take in experiment 2 (where more cells were implanted). Conclusion Evaluating fractionated alpha-RIT with At-211-labeled anti-PSCA A11 minibody, we found clear growth inhibition on both macrotumors and intratibial microtumors. For mice treated with multiple fractions, we also observed radiotoxicity manifested by progressive loss in body weight at 30 to 90 days after treatment. Our findings are conceptually promising for a systemic TAT of mCRPC and warrant further investigations of At-211-labeled PSCA-directed vectors. Such studies should include methods to improve the therapeutic window, e.g., by implementing a pretargeted regimen of alpha-RIT or by altering the size of the targeting vector.
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| 7. |
- Dulic, Tomislav, 1968-
(författare)
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Utopias of Nation : Local Mass Killing in Bosnia and Herzegovina, 1941-42
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study analyses the mechanisms of local mass violence perpetrated by the Croatian fascist Ustasha organisation and the Serbian nationalist Chetniks in Bosnia and Herzegovina during 1941–42. A theoretical and methodological model has been devised, that is based on an investigation the three “dimensions” of mass killing, namely intent, systematics and magnitude. Each of the dimensions are connected to the three phases of conceptualisation, implementation and realisation, which forms the “process of mass killing”.The conceptualisation phase relates to how the actors conceived their ideas of “ethnic purification” and exclusion, and how the ideology was mediated to the public. The analysis of the implementation phase aims at identifying the phases and levels of systematic destruction, and the social processes at work in the local communities, including how victims tried to cope and avoid perseution, public responses, and the motives for participating in terror. The third phase is dedicated to a statistical analysis in order to identify the magnitude of destruction, victim categories and the effects of policy changes.The empirical data is based on documents originating with the main belligerents, witness statements, memoirs, and statistical data. The conclusions are that the killings and persecution were well organised, although there were differences between the main belligerents. The study also shows that propaganda played a less important role for participation in mass killing than is frequently believed, while factors such as insecurity and the prospect of personal gain were more salient. The theoretical and methodological ap-proach proved particularly useful, since it showed that local circumstances significantly affect the destruction process. At the same time, the study identifies a strong correlation between decision-making on the political level and local mass killing.
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| 8. |
- Eriksson, Sophie, et al.
(författare)
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Sequential Radioimmunotherapy with (177)Lu- and (211)At-Labeled Monoclonal Antibody BR96 in a Syngeneic Rat Colon Carcinoma Model.
- 2014
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Ingår i: Cancer biotherapy & radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1557-8852 .- 1084-9785. ; 29:6, s. 238-246
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Alpha-particle emitters, such as astatine-211 ((211)At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 ((177)Lu), have a longer path length and are considered better for small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a (177)Lu-labeled antibody, followed by a (211)At-labeled antibody 25 days later. Methods: Rats bearing solid colon carcinoma tumors were treated with 400MBq/kg body weight (177)Lu-BR96. After 25 days, three groups of animals were given either 5 or 10MBq/kg body weight of (211)At-BR96 simultaneously with or without a blocking agent reducing halogen uptake in normal tissues. Control animals were not given any (211)At-BR96. Myelotoxicity, body weight, tumor size, and development of metastases were monitored for 120 days. Results: Tumors were undetectable in 90% of the animals on day 25, independent of treatment. Additional treatment with (211)At-labeled antibodies did not reduce the proportion of animals developing metastases. The rats suffered from reversible myelotoxicity after treatment. Conclusions: Sequential administration of (177)Lu-BR96 and (211)At-BR96 resulted in tolerable toxicity providing halogen blocking but did not enhance the therapeutic effect.
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| 9. |
- Eriksson, Sophie, et al.
(författare)
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Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb.
- 2013
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Ingår i: EJNMMI research. - 2191-219X. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with alpha-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing alpha-particle emitting radionuclides is considered especially suitable for the treatment of small cell clusters and single cells, although lesions of different sizes may also be present in the patient. The aim of this study was primarily to evaluate the toxicity and secondarily in vivo efficacy of a 211At-labeled monoclonal antibody (mAb) directed against colon carcinoma with tumor diameters of approximately 10 mm. METHODS: Eighteen rats with subperitoneal syngeneic colon carcinoma were allocated to three groups of six animals together with three healthy rats in each group. The groups were injected intravenously with either 150 mug of unlabeled mAbs (controls) or 2.5 or 5 MBq 211At-mAbs directed towards the Lewis Y antigen expressed on the cell membrane of several carcinomas. Tumor volume, body weight, and blood cell counts were monitored for 100 days after treatment. RESULTS: Local tumors were non-palpable in five out of six rats after treatment with both activities of 211At-mAbs, compared to one out of six in the control group. At the study end, half of the animals in each group given 211At-BR96 and one animal in the control group were free from disease. Radioimmunotherapy resulted in dose-dependent, transient weight loss and myelotoxicity. Survival was significantly better in the groups receiving targeted alpha therapy than in those receiving unlabeled mAbs. CONCLUSIONS: This study demonstrates the possibility of treating small, solid colon carcinoma tumors with alpha-emitting radionuclides such as 211At bound to mAbs, with tolerable toxicity.
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| 10. |
- Erlandsson, Susanna, 1970-
(författare)
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Window of opportunity : Dutch and Swedish security ideas and strategies 1942–1948
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The period treated in this thesis is one which is often characterized as a transition between World War II and the Cold War. By approaching it instead as a window of opportunity – a period in which the governments of small states perceived both an unusual space and an urgent need to reevaluate security – the security policies of two small northwestern European countries, the Netherlands and Sweden, are subjected to a critical reappraisal. Through a systematic comparison of the security ideas and strategies in two countries that ended up with different positions on alignment/non-alignment during the Cold War, this dissertation sheds new light on the reasons for the development of those security policies as well as on their significance. Not only does it uncover a number of concrete security strategies that were remarkably similar regardless of different circumstances, but it shows that the Swedish and Dutch governments formed similar ideas about the needs for future security in spite of different war experiences. Both concluded that small states could no longer survive in isolation and instead aimed for a better functioning system of collective security, built on the close cooperation of regional groups. This thesis argues that the different choices regarding security in 1948, when the Dutch signed the Treaty of Brussels and the Swedish reclaimed a policy of non-alignment, were in fact motivated by the same wish to maintain as wide a margin for manoeuvre as possible for the cooperation envisioned during the war, seeing this as the best guarantee of peace and independence.
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