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- Abrahamsson, Ingemar, 1953, et al.
(författare)
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Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog
- 2004
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Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 15:4, s. 381-92
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To validate a proposed model (Berglundh et al. 2003) and to evaluate the rate and degree of osseointegration at turned (T) and sand blasted and acid etched (SLA) implant surfaces during early phases of healing. MATERIAL AND METHODS: The devices used for the study of early healing had a geometry that corresponded to that of a solid screw implant with either a SLA or a T surface configuration. A circumferential trough had been prepared within the thread region (intra-osseous portion) that established a geometrically well-defined wound chamber. Twenty Labrador dogs received totally 160 experimental devices to allow the evaluation of healing between 2 h and 12 weeks. Both ground and decalcified sections were prepared from mesial/distal and buccal/lingual device sites. Histometric and morphometric analyses of the ground sections and morphometric analysis of the tissue components in decalcified sections were performed. RESULTS: The ground sections provided an overview of the various phases of tissue formation, while the decalcified, thin sections enabled a more detailed study of events involved in bone tissue modeling and remodeling for both SLA and T surfaces. The initially empty wound chamber became occupied with a coagulum and a granulation tissue that was replaced by a provisional matrix. The process of bone formation started already during the first week. The newly formed bone present at the lateral border of the cut bony bed appeared to be continuous with the parent bone, but on the SLA surface woven bone was also found at a distance from the parent bone. Parallel-fibered and/or lamellar bone as well as bone marrow replaced this primary bone after 4 weeks. In the SLA chambers, more bone-to-device contact, more initial woven bone and earlier lamellar bone formation was found than in the T chambers. CONCLUSION: Osseointegration represents a dynamic process both during its establishment and its maintenance. While healing showed similar characteristics with resorptive and appositional events for both SLA and T surfaces, the rate and degree of osseointegration were superior for the SLA compared with the T chambers.
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- Abrahamsson, Ingemar, 1953, et al.
(författare)
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Healing at Implants Placed in an Alveolar Ridge with a Sloped Configuration: An Experimental Study in Dogs.
- 2014
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Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899. ; 16:1, s. 62-69
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To study healing around implants placed in an alveolar ridge with a sloped lingual-buccal configuration. Materials and Methods: Six Labrador dogs were used. Buccal bone defects were prepared in the mandible after extraction of premolars. Three months later, two test implants with a sloped marginal design and two control implants were placed in the chronic defect area with a sloped lingual-buccal configuration of each premolar region. The test implants were placed in such a way that the buccal margin of the implant coincided with the buccal bone crest. The lingual margin of the control implants was placed to a similar depth as the lingual margin of the test implants. Abutments were connected to the implants in the right mandibular premolar region and flaps were sutured around the neck of the abutments. In the left side of the mandible, cover screws were placed and the flaps were sutured to cover the implants. Biopsies were obtained 4 months later and prepared for histological examination. Results: It was demonstrated that healing around implants placed in an alveolar ridge with a sloped lingual-buccal configuration resulted in the preservation of a vertical discrepancy between the lingual and buccal marginal bone levels around implants with either a regular cylindrical outline or a modified marginal portion that matched the slope of the alveolar ridge. Conclusion: As the marginal buccal portion of the control implants with a regular design had no bone support, it is suggested that implants with a modified marginal portion may be considered in recipient sites with a sloped lingual-buccal configuration.
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- Araújo, M, et al.
(författare)
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Effect of a xenograft on early bone formation in extraction sockets: an experimental study in dog.
- 2009
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Ingår i: Clinical oral implants research. - : Wiley. - 1600-0501 .- 0905-7161. ; 20:1, s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The aim of this study was to study the effect on early bone formation resulting from the placement of a xenograft in the fresh extraction socket in dogs. MATERIAL AND METHODS: Five beagle dogs were used. The distal roots of the third and fourth mandibular premolars were removed. In one quadrant, a graft consisting of Bio-Oss Collagen was placed in the fresh extraction wound, while the corresponding premolar sites in the contra-lateral jaw quadrant were left non-grafted. After 2 weeks of healing, the dogs were perfused with a fixative, the mandibles removed, the experimental sites dissected, demineralized, sectioned in the mesio-distal plane and stained in hematoxyline-eosine. RESULTS: The central portion of the non-grafted sockets was occupied by a provisional matrix comprised of densely packed connective tissue fibers and mesenchymal cells. Apical and lateral to the provisional matrix, newly formed woven bone was found to occupy most of the sockets. In the apical part of the grafted sockets, no particles of the xenograft could be observed but newly formed bone was present in this portion of the experimental site. In addition, limited numbers of woven bone trabeculae occurred along the lateral socket walls. The central and marginal segments of the grafted sockets, however, were occupied by a non-mineralized connective tissue that enclosed Bio-Oss particles that frequently were coated by multinucleated cells. CONCLUSIONS: The placement of Bio-Oss Collagen in the fresh extraction wound obviously delayed socket healing. Thus, after 2 weeks of tissue repair, only minute amounts of newly formed bone occurred in the apical and lateral borders of the grafted sockets, while large amounts of woven bone had formed in most parts of the non-grafted sites.
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| 7. |
- Araújo, Mauricio G, 1966, et al.
(författare)
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Bio-Oss collagen in the buccal gap at immediate implants: a 6-month study in the dog.
- 2011
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Ingår i: Clinical oral implants research. - : Wiley. - 1600-0501 .- 0905-7161. ; 22:1, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- following tooth extraction and immediate implant installation, the edentulous site of the alveolar process undergoes substantial bone modeling and the ridge dimensions are reduced. objective: the objective of the present experiment was to determine whether the process of bone modeling following tooth extraction and immediate implant placement was influenced by the placement of a xenogenic graft in the void that occurred between the implant and the walls of the fresh extraction socket.
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| 8. |
- Araújo, Mauricio G, 1966, et al.
(författare)
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The influence of Bio-Oss collagen on healing of an extraction socket: An experimental study in the dog.
- 2008
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Ingår i: The International Journal of Periodontics & Restorative Dentistry. - 0198-7569. ; 28:2, s. 123-135
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Tidskriftsartikel (refereegranskat)abstract
- Background: Different approaches were advocated to preserve or improve the dimension and contour of the ridge following tooth extraction. In some of studies socket grafting apparently had a successful outcome while in other reports the benefits of such therapy were more questionable. Aim: The objective of the present experiment was to evaluate the effect on hard tissue modeling and remodeling of the placement of a xenograft in the fresh extraction socket in dogs. Material and Methods: Five mongrel dogs were used. Two mandibular premolars (4P4) were hemi-sected. The distal roots were carefully removed. In one socket, a graft consisting of Bio-Oss® Collage was placed while the contra-lateral site was left without grafting. After 3 months of healing, the dogs were euthanized and biopsies sampled. From each experimental site, 4 ground sections – 2 from the mesial root and 2 from the healed socket – were prepared, stained and examined in the microscope. Results: The placement of Bio-Oss® Collagen in the fresh extraction socket failed to inhibit the processes of modeling and remodeling that took place in the socket walls following tooth extraction. The biomaterial, however, apparently promoted de novo hard tissue formation, in particular in the cortical region of the extraction site. Hereby, the dimension of the hard tissue was maintained and the profile of the ridge was better preserved. Conclusion: The placement of a biomaterial in an extraction socket may promote bone modeling and at least temporarily compensate for marginal ridge contraction.
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| 9. |
- Carcuac, Olivier, 1974, et al.
(författare)
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Experimental periodontitis and peri-implantitis in dogs
- 2013
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Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161. ; 24:4, s. 363-371
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Aim: To analyze the tissue reactions following ligature removal in experimental periodontitis and peri-implantitis in dogs. Material and methods: Four implants with similar geometry and with two different surface characteristics (turned/TiUnite Nobel BioCare AB, Go ̈ teborg) were placed pair-wise in a randomized order in the right side of the mandible 3 months after tooth extraction in 5 dogs. Experimental peri-implantitis and periodontitis were initiated 3 months later by ligature placement around implants and mandibular premolars and plaque formation. The ligatures were removed after 10 weeks, and block biopsies were obtained and prepared for histological analysis 6 months later. Results: It was demonstrated that the amount of bone loss that occurred during the period following ligature removal was significantly larger at implants with a modified surface than at implants with a turned surface and at teeth. The histological analysis revealed that peri-implantitis sites exhibited inflammatory cell infiltrates that were larger, extended closer to the bone crest and contained larger proportions of neutrophil granulocytes and osteoclasts than in periodontitis. Conclusion: It is suggested that lesions produced in experimental periodontitis, and peri- implantitis are different and that implant surface characteristics influence the inflammatory process in experimental peri-implantitis and the magnitude of the resulting tissue destruction.
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