| 1. |
- Lu, Yingchang, et al.
(författare)
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
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| 2. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 3. |
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| 4. |
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| 5. |
- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 6. |
- Lindgren, Anne-Li, 1965-, et al.
(författare)
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Blogging Family-like Relations when visiting Theme and Amusement Parks : The Use of Children in Displays Online
- 2014
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Ingår i: Culture Unbound. Journal of Current Cultural Research. - : Linköping University Electronic Press. - 2000-1525 .- 2000-1525. ; 6:55, s. 997-1013
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Tidskriftsartikel (refereegranskat)abstract
- This paper combines sociological perspectives on family display, internet studies on family and private photography and a child studies perspective on the display of children. The paper proposes that blogging practices related to visits to theme and amusement parks in Sweden provide a new arena for people to displayfami-ly-like relationships. In the different displays,adults mainly use pictures of chil-dren in the blogs to demonstratetheir ability to perform family-likerelationships. The paper suggests that thisform of child-centred display,a visualized child-centredness, done during the park visit as well as in the blogging, is part of the construction of contemporary childhoods and what it means to be a child today and has not been theorized in earlier research on the display of family-like rela-tions.
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| 7. |
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| 8. |
- Lindgren, Anne-Li, 1965-, et al.
(författare)
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Enacting (real) fiction : Materializing childhoods in a theme park
- 2015
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Ingår i: Childhood. - : Routledge. - 0907-5682 .- 1461-7013. ; 22:2, s. 171-186
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Tidskriftsartikel (refereegranskat)abstract
- Even though fiction and fantasy are fundamental to how childhoods today are understood, thisis a topic that is seldom explored either theoretically or academically. We address the questionof how the relationship between material real and fictive real can be understood in new ways incontemporary society. We suggest that fiction can be understood in other ways than the hithertodichotomized approaches to it, and our aim is to focus on the hybridity that is created throughthe interconnecting word and, as in fiction and childhood and material real and fictive real. Thisarticle explores how fiction can be understood as hybrid and interrelated rather than a pure andseparate phenomenon, and in particular how materiality as something real and fiction as realmingle. This article introduces ways to talk about the fictive real as realunreality and highlightsthe drawbacks that might stem from these concepts since in several ways they re-enact childhoodinnocence and nostalgia, as well as negative differences between childhood and adulthood, wheredifferent childhoods share a subordinate position in society.
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| 9. |
- Lindgren, Anne-Li, 1965-, et al.
(författare)
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Film i klassrummet reser välfärdsfrågor
- 2005
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Ingår i: Locus. - 1100-3197. ; 3-4, s. 14-25
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Vad händer när unga ser film i skolan? I denna artikel redgör författarna för innehållet i de diskussioner tonåringar förde efter att ha sett filmerna Lilya 4-ever, Ondskan och Om en pojke. I samtalen lyftes bland annat frågor om välfärdspolitik. Författarna menar att populärkultur inte bör betraktas som "skräp" eller "bara" underhållning eftersom man då missar en viktig del av barns och ungas meningsskapande.
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| 10. |
- Lindgren, Anne-Li, 1965-, et al.
(författare)
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From Instruction to Reflection : Film in Education in Sweden
- 2012
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Ingår i: Research in media education. - New York : Nova Science Publishers, Inc.. - 9781612096438 ; , s. 151-174
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Today, people know what is happening around them through radio, television, newspapers and the like. With the advance of the telecommunication technology, people are now also familiar with the use of personal computers, the Internet and so on. The mass media is now regarded as essential for keeping people up to date with the world around them. In view of this, the innovation of a new curriculum, media education or the study of the mass media, has been recommended. This book examines the prevailing perspectives regarding media education in different countries around the world and what kinds of research is being conducted in the field of media education.
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