| 1. |
|
|
| 2. |
|
|
| 3. |
- Franceschini, N., et al.
(författare)
-
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
|
|
| 4. |
|
|
| 5. |
- Martinsson, Johan, et al.
(författare)
-
Impacts of Combustion Conditions and Photochemical Processing on the Light Absorption of Biomass Combustion Aerosol
- 2015
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 49:24, s. 14663-14671
-
Tidskriftsartikel (refereegranskat)abstract
- The aim was to identify relationships between combustion conditions, particle characteristics, and optical properties of fresh and photochemically processed emissions from biomass combustion. The combustion conditions included nominal and high burn rate operation and individual combustion phases from a conventional wood stove. Low temperature pyrolysis upon fuel addition resulted in "tar-ball" type particles dominated by organic aerosol with an absorption Angstrom exponent (AAE) of 2.5-2.7 and estimated Brown Carbon contributions of 50-70% to absorption at the climate relevant aethalometer-wavelength (520 nm). High temperature combustion during the intermediate (flaming) phase was dominated by soot agglomerates with AAE 1.0-1.2 and 85-100% of absorption at 520 nm attributed to Black Carbon. Intense photochemical processing of high burn rate flaming combustion emissions in an oxidation flow reactor led to strong formation of Secondary Organic Aerosol, with no or weak absorption. PM1 mass emission factors (mg/kg) of fresh emissions were about an order of magnitude higher for low temperature pyrolysis compared to high temperature combustion. However, emission factors describing the absorption cross section emitted per kg of fuel consumed (m(2)/kg) were of similar magnitude at 520 nm for the diverse combustion conditions investigated in this study. These results provide a link between biomass combustion conditions, emitted particle types, and their optical properties in fresh and processed plumes which can be of value for source apportionment and balanced mitigation of biomass combustion emissions from a climate and health perspective.
|
|
| 6. |
|
|
| 7. |
- Molin, Nils-Erik, et al.
(författare)
-
Eigenmodes of av violin body
- 1990
-
Ingår i: Proceedings / Nordic Acoustical Meeting 90 - NAM 90. - Luleå : CENTEK. - 9186998390 ; , s. 421-428
-
Konferensbidrag (refereegranskat)
|
|
| 8. |
- Molin, Nils-Erik, et al.
(författare)
-
Parameters of violin plates and their influence on the plate modes
- 1988
-
Ingår i: Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966 .- 1520-8524. ; 83:1, s. 281-291
-
Tidskriftsartikel (refereegranskat)abstract
- Noncontact measuring methods and numerical calculations are used in a study of musical instruments. First, a simple method to determine the material parameters of a blank to a violin plate is presented. Eigenmodes of rectangular free-free violin wooden blanks are determined using optical nondestructive methods, Chladni patterns, or tapping. Assuming orthotropic material, the first three eigenmodes for such a blank are calculated using the finite element method (FEM). It is shown that the frequency of each eigenmode depends on separate elastic parameters. With this one variable dependence, it is a simple task to determine effective material parameters for quarter-cut standard wooden blanks when the frequencies and mass are known. Second, the violin maker's problem with the influence of material and geometrical parameters on the vibration modes is investigated. Numerical models and corresponding real violin plates are made from the spruce and the maple blanks. Good agreement between calculated and experimentally obtained plate modes is found. Calculations with a 10% variation in each parameter are thereafter used to give information about the influence of overall plate thickness variation, of local thickness variations, of changes in arch-height, and of material parameters. Third, boundary conditions for the plates when glued to the ribs are examined in a pilot experiment.
|
|
| 9. |
- Chen, X., et al.
(författare)
-
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
- 2018
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 27:10, s. 1809-1818
-
Tidskriftsartikel (refereegranskat)abstract
- Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein (oxLDL), apoptotic cells and several pathogens like Streptococcus pneumoniae. Immunoglobulin M against PC (IgM anti-PC) has the ability to inhibit uptake of oxLDL by macrophages and increase clearance of apoptotic cells. From our genome-wide association studies (GWASs) in four European-ancestry cohorts, six single nucleotide polymorphisms (SNPs) in 11q24.1 were discovered (in 3002 individuals) and replicated (in 646 individuals) to be associated with serum level of IgM anti-PC (the leading SNP rs35923643-G, combined beta = 0.19, 95% confidence interval 0.13-0.24, P = 4.3 x 10-11). The haplotype tagged by rs35923643-G (or its proxy SNP rs735665-A) is also known as the top risk allele for chronic lymphocytic leukemia (CLL), and a main increasing allele for general IgM. By using summary GWAS results of IgM anti-PC and CLL in the polygenic risk score (PRS) analysis, PRS on the basis of IgM anti-PC risk alleles positively associated with CLL risk (explained 0.6% of CLL variance, P = 1.2 x 10-15). Functional prediction suggested that rs35923643-G might impede the binding of Runt-related transcription factor 3, a tumor suppressor playing a central role in the immune regulation of cancers. Contrary to the expectations from the shared genetics between IgM anti-PC and CLL, an inverse relationship at the phenotypic level was found in a nested case-control study (30 CLL cases with 90 age- and sex-matched controls), potentially reflecting reverse causation. The suggested function of the top variant as well as the phenotypic association between IgM anti-PC and CLL risk needs replication and motivates further studies.
|
|
| 10. |
- Eriksson, Karl-Erik, et al.
(författare)
-
Bifurcation in Quantum Measurement
- 2017
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We present a generic model of (non-destructive) quantum measurement. It consists of two-level system μ interacting with a larger system A, in such a way that if μ is initially in one of the chosen basis states, it does not change but makes A change into a corresponding state (entanglement). The μA-interaction is described as a scattering process. Internal (unknown) variables of A may influence the transition amplitudes. It is assumed that the statistics of these variables is such that, in the mean, the μA-interaction is neutral with respect to the chosen basis states. It is then shown that, for a given initial state of μ, in the limit of a large system A, the statistics of the ensemble of available initial states leads to a bifurcation: those initial states of A that are efficient in leading to a final state, are divided into two separated subsets. For each of these subsets, μ ends up in one of the basis states. The probabilities in this branching confirm the Born rule.
|
|
