| 1. |
- Eriksson Krutrök, Moa, et al.
(författare)
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Continued contexts of terror : analyzing temporal patterns of hashtag co-occurrence as discursive articulations
- 2018
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Ingår i: Social Media + Society. - : Sage Publications. - 2056-3051. ; 4:4
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Tidskriftsartikel (refereegranskat)abstract
- This study looks at how terror attacks are rendered discursively meaningful on social media through the concurrent use and reiteration of terror hashtags, which were created following previous incidents of terror. The article focuses on 12 terror attacks in Europe in 2015-2017 and their relating hashtags on Twitter, to see how various combinations of these were reused and co-articulated in tweets posted in relation to subsequent attacks. Through social network analysis of co-occurring hashtags in about 3 million tweets, in combination with close readings of a smaller sample, this study aims to analyze both the networks of hashtags in relation to terror attacks as well as the discursive process of hashtag co-articulation. The study shows that the patterns by which attack hashtags are reused and co-articulated depend on both temporal and contextual differences.
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| 2. |
- Eriksson Krutrök, Moa
(författare)
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Digital aftermaths of terror : reactions to terrorist attacks on twitter
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background. This thesis explores digital public reactions to terrorist attacks, and specifically how discourses on terrorism become articulated on social media. The overarching aim of the thesis is to explore the reactions spread on social media following attacks, and how these digital platforms may alter or transform the ways in which such attacks are collectively understood and interpreted. It explores issues relating to Twitter as a platform for backchannel meaning making, for downplaying fear mongering practices, the ways different terrorist attacks become co-articulated, as well as the divided attention of networked publics during terror-related events.Methods. The thesis is made up of four individual papers, each exploring digital reactions to different terrorist attacks on Twitter. The cases include the Utøya massacre in Norway 2011, the Stockholm lorry attack in 2017, 12 different attacks occurring between 2015-2017 in Europe (multi-case study), and the terrorist attack in Sinai, Egypt and the subsequent false alarm about a suspected terrorist attack on Oxford Street Underground station in London, UK, occuring on the same day in 2017. A combination of methods used in this thesis include network analysis of hashtag co-occurrences, and thematic analysis of prominent themes in tweets, using discourse theory as its analytical framework in the qualitative readings. Results. The findings of the thesis suggest that discourses on terrorism on social media are shaped by the specific logics present in the connective action of networked publics. The political action of digital audiences is performed in a personalised way that shapes terrorism discourse. How terrorism is understood is influenced by collective ideas of how societies become affected by trauma or resilience, and digital communities engage in downplaying or amplifying practices for such articulations. Prevailing spatial and temporal contexts alsomatter for the ways in which terrorist attacks are understood and reimagined. The (real or perceived) closeness to the attack, the interrelatedness of attacks, and aspects of virality of information plays a role in how terror discourses become articulated in digital spaces. Conclusion. This thesis makes theoretical and empirical contributions to the understanding of how digital audiences articulate terrorism discourse in the aftermath of terrorist attacks. It stresses that emotive personal expressions on social media should be understood as a highly politicised reaction, relating to a vast range of issues, such as immigration control, nationalism, or an increased prevalence of everyday racism. On social media, audiences may both amplify or downplay attention to specific terrorist attacks, and, as such, may choose to provide (or not provide) attention. Social media may thus function as a space for everyday political action in times of terrorism.
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| 3. |
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| 4. |
- Eriksson Krutrök, Moa, et al.
(författare)
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Social media amplification loops and false alarms : towards a sociotechnical understanding of misinformation during emergencies
- 2022
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Ingår i: The Communication review. - : Taylor & Francis. - 1071-4421 .- 1547-7487. ; 25:2, s. 81-95
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Tidskriftsartikel (refereegranskat)abstract
- In the immediate aftermath of crisis events, there is a pressing demand among the public for information about what is unfolding. In such moments "information holes" occur, people and organizations collaborate to try to fill these in real time by sharing information. In this article, we approach such gaps not merely as the product of the actual lack of information, but as generated by the algorithmically underpinned social media platforms as such, and by the user behaviors that they proliferate. The lack of information is the result of the noisy and fragmented patchwork of information that social media platforms can generate. In this paper, we draw on a case study of one particular case of a false terrorism alarm and its unfolding on Twitter, that took place in London's Oxford Circus underground station in November of 2017. Using a combination of computational and interpretive methods – analyzing social network structure as well as textual expressions – we find that certain logics of platforms may affect emergency management and the work of emergency responders negatively.
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| 5. |
- Hägglund, Moa, et al.
(författare)
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Accounting for bacterial overlap between raw water communities and contaminating sources improves the accuracy of signature-based microbial source tracking
- 2018
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Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Microbial source tracking (MST) analysis is essential to identifying and mitigating the fecal pollution of water resources. The signature-based MST method uses a library of sequences to identify contaminants based on operational taxonomic units (OTUs) that are unique to a certain source. However, no clear guidelines for how to incorporate OTU overlap or natural variation in the raw water bacterial community into MST analyses exist. We investigated how the inclusion of bacterial overlap between sources in the library affects source prediction accuracy. To achieve this, large-scale sampling-including feces from seven species, raw sewage, and raw water samples from water treatment plants - was followed by 16S rRNA amplicon sequencing. The MST library was defined using three settings: (i) no raw water communities represented; (ii) raw water communities selected through clustering analysis; and (iii) local water communities collected across consecutive years. The results suggest that incorporating either the local background or representative bacterial composition improves MST analyses, as the results were positively correlated to measured levels of fecal indicator bacteria and the accuracy at which OTUs were assigned to the correct contamination source increased fourfold. Using the proportion of OTUs with high source origin probability, underpinning a contaminating signal, is a solid foundation in a framework for further deciphering and comparing contaminating signals derived in signature-based MST approaches. In conclusion, incorporating background bacterial composition of water in MST can improve mitigation efforts for minimizing the spread of pathogenic and antibiotic resistant bacteria into essential freshwater resources.
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| 6. |
- Lindgren, Moa, et al.
(författare)
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Type IV collagen as a potential biomarker of metastatic breast cancer
- 2021
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Ingår i: Clinical and Experimental Metastasis. - : Springer. - 0262-0898 .- 1573-7276. ; 38:2, s. 175-185
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Tidskriftsartikel (refereegranskat)abstract
- No reliable, non-invasive biomarker of metastatic breast cancer (mBC) exists: circulating CA15-3 (cCA15-3) is the marker mostly used to monitor mBC. Circulating collagen IV (cCOLIV) has been evaluated in other metastatic cancers and has been found to be a promising biomarker. The overarching aim of this study was to evaluate cCOLIV as a potential biomarker in patients with mBC. The first aim was to determine the levels of cCOL IV and cCA15-3 in patients with healthy controls, primary breast cancer (pBC) and mBC. The second aim was to compare levels of cCOLIV and cCA15-3 in patients with different metastatic sites of BC. The third aim was to investigate the prognostic value of cCOLIV and cCA15-3 for mBC patients. The fourth aim was to analyse whether a combination of the two biomarkers was more accurate in detecting mBC than a single marker. Lastly, we investigated the tissue expression levels of COLIV in BC bone metastases (BM) and liver metastases (LM). Plasma levels of cCOLIV and cCA15-3 from healthy controls and patients with pBC and mBC were measured. COLIV expression in tissue from patients with LM and BM was analysed using immunohistochemistry. Clinical and survival data were collected from medical charts. The levels of cCOLIV and cCA15-3 were significantly elevated in mBC patients compared with healthy controls and pBC patients. No differences in cCOLIV and cCA15-3 levels were found based on the metastatic site. High levels of cCOLIV, but not cCA15-3, correlated with poorer survival. cCOLIV alone and the combination of cCA15-3 and cCOLIV were superior to cCA15-3 at detecting mBC. COL IV was highly expressed in the tissue of LM and BM. Our study suggests that cCOLIV is a potential marker to monitor patients with BC.
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| 7. |
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| 8. |
- Lindgren, Moa, 1990-
(författare)
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Type IV collagen in breast and colorectal cancer : a potential biomarker of metastatic disease
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Metastatic colorectal cancer (mCRC) and metastatic breast cancer (mBC) are two leading causes of cancer-related mortality worldwide. Early detection of metastatic disease is critical, and sensitive, easily accessed and cost-effective biomarkers that can diagnose mBC and mCRC at an early stage would have high clinical value. The best circulating markers: CEA and CA 15-3 are suboptimal, but a combination with other proteins can improve their potential to detect metastatic disease. One potential source of new biomarkers is the tumor stroma, including the extracellular matrix (ECM), vasculature, and stromal cells like immune cells and fibroblasts. Both the tumor cell and stromal compartment are vital for cancer progression. A combination of biomarkers from both compartments could likely best reflect the heterogeneous nature of the metastatic disease. Stromal type IV collagen (COL IV) is the main constituent of the basement membrane of healthy tissues. COL IV is upregulated with some cancers, including colorectal liver metastases (CLM), and is considered a potential biomarker for CLM. The origin of elevated levels of COL IV in CLM is not known but may result from both increased ECM production and ECM degradation associated with cancer-related tumor stroma remodeling. Aims: In this thesis, COL IV and its potential to be used as a biomarker for mCRC and mBC is studied, with a specific emphasis on liver metastases. The aims are to compare levels of circulating COL IV (cCOL IV) in mCRC and mBC patients with controls and evaluate its diagnostic and prognostic value; to evaluate the combination of cCOL IV with other proteins; to determine the cellular origin of COL IV in CLM and study COL IV expression in cell lines; to study the expression of COL IV degrading proteases in CLM and to evaluate tissue expression of COL IV in bone and liver metastases from BC patients. Methods: Plasma levels of cCOL IV, CA 15-3, CEA, and other cancer-related proteins were analyzed with ELISA, ECLIA and Multiplex assay in mCRC and mBC patients, healthy controls and patients with primary CRC or BC as controls. The cellular origin of COL IV expression in CLM was examined with in situ hybridization, and the expression of COL IV in mBC tissue and COL IV degrading proteases (MMP -2, -7, -9 and -13) in CLMs were studied with immunohistochemistry. COL IV expression in CRC and fibroblast cell lines was analyzed with immunofluorescence.Results: cCOL IV is elevated in mBC patients and correlates with poor survival. The combination of cCOL IV with CA 15-3 and cCOL IV alone are superior to CA 15-3 at detecting mBC. COL IV is highly expressed in the tissue of liver- and bone BC metastases. Circulating COL IV, CEA, OPN, CYFRA 21-1, IL-8, HGF, and MIF are elevated, and TRAIL is lower in mCRC patients compared with controls. COL IV, CEA, OPN, CYFRA 21-1, and IL-8 were higher, and TRAIL was lower in mCRC patients with liver metastases compared to patients with extrahepatic disease. Circulating CEA, OPN, and HGF are very good, and cCOL IV is acceptable at distinguishing mCRC patients from patients with primary CRC. The combination of OPN + CEA is superior to CEA alone at detecting mCRC. High HGF and cCOL IV (one cohort) in mCRC patients correlate to poor prognosis. cCOL IV is elevated in CLM patients compared to healthy controls and is very good at discriminating between healthy controls and CLM patients. COL IV is expressed in CLM by cancer-associated fibroblasts, and COL IV degrading proteases are expressed primarily by stromal cells in CLM. COL IV is expressed by fibroblasts, not tumor cells, in vitro. Conclusion: cCOL IV is a promising tumor marker of metastatic BC and CRC and circulating HGF and OPN are potential biomarkers of mCRC. Our results show that the metastatic site can impact the circulating levels of numerous cancer-related proteins, which aligns with our hypothesis that combining biomarkers instead of using one might be best for detecting metastatic cancer through blood analysis. COL IV is expressed by stromal cells, not tumor cells, in CLM tissue and in vitro.
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| 9. |
- Lindgren, Moa, et al.
(författare)
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Type IV Collagen in Human Colorectal Liver Metastases—Cellular Origin and a Circulating Biomarker
- 2022
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:14
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Tidskriftsartikel (refereegranskat)abstract
- Circulating type IV collagen (cCOL IV) is a potential biomarker for patients with colorectal liver metastases (CLM) who present with elevated levels of COL IV in both CLM tissue and circulation. This study aimed to establish the cellular origin of elevated levels of COL IV and analyze circulating COL IV in CLM patients. The cellular source was established through in situ hybridization, immunohistochemical staining, and morphological evaluation. Cellular expression in vitro was assessed by immunofluorescence. Tissue expression of COL IV-degrading matrix metalloproteinases (MMPs)-2, -7, -9, and -13 was studied with immunohistochemical staining. Plasma levels of COL IV in CLM patients and healthy controls were analyzed with ELISA. This study shows that cancer-associated fibroblasts (CAFs) express COL IV in the stroma of CLM and that COL IV is expressed in vitro by fibroblasts but not by tumor cells. MMP-2, -7, -9, and -13 are expressed in CLM tissue, mainly by hepatocytes and immune cells, and circulating COL IV is significantly elevated in CLM patients compared with healthy controls. Our study shows that stromal cells, not tumor cells, produce COL IV in CLM, and that circulating COL IV is elevated in patients with CLM.
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| 10. |
- Lindgren, Simon, 1974-, et al.
(författare)
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Researching digital media and society
- 2024
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Bok (refereegranskat)abstract
- We live in an increasingly digitised society. In an age of digital identities, rapid developments in Artificial Intelligence and ever more sophisticated software available, our methods for researching digital media must be flexible and adaptable. This book will help you to understand why researchers in this field choose and use particular research methods, equipping you to put these methods into practice across the whole range of undergraduate media courses. This book shows you how research methods can help us to make sense of the myriad of information we encounter online every day, from Tiktok influencers to viral Twitter posts. Complete with case studies in each chapter, the book covers both well-established methods, such as network analysis, and cutting-edge ones, such as interface analysis. It provides a crucial foundation for research in digital media, demonstrating the scope and potential of these tools. The book adopts an easy-to-navigate structure, taking you through specific methods in a systematic way. It shows you examples of classic uses of each method, and directs you towards further resources after each chapter.
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