| 1. |
- Andaloussi, Mounir, et al.
(författare)
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Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates.
- 2009
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Ingår i: Chemistry - A European Journal. - Weinheim : Wiley-VCH Verlag GmbH. - 0947-6539 .- 1521-3765. ; 15:47, s. 13069-13074
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Tidskriftsartikel (refereegranskat)abstract
- The first Pd-II-catalyzed P arylation has been performed by using palladium acetate, the rigid bidentate ligand dmphen (dmphen=2,9-dimethyl-1,10-phenanthroline), and without the addition of base or acid. Couplings of arylboronic acids or aryl trifluoroborates with H-phosphonate dialkyl esters were conducted in 30 min with controlled microwave (MW) heating under non-inert conditions. Aryl phosphites were also synthesized at room temperature with atmospheric air as the sole reoxidant. The arylated phosphonates were isolated in 44-90% yields. The excellent chemoselectivity of the method was illustrated in the synthesis of a Mycobacterium tuberculosis glutamine synthetase (MTB-GS) inhibitor. Online ESIMS was used to detect cationic palladium species in ongoing reactions directly, and a catalytic cycle has been proposed based on these results.
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| 2. |
- Axelsson, Linda, et al.
(författare)
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An Improved Palladium(II)-Catalyzed Method for the Synthesis of Aryl Ketones from Aryl Carboxylic Acids and Organonitriles
- 2014
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Ingår i: Tetrahedron Letters. - : Elsevier BV. - 0040-4039 .- 1359-8562. ; 55:15, s. 2376-2380
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Tidskriftsartikel (refereegranskat)abstract
- A palladium(II)-catalyzed decarboxylative protocol for the synthesis of aryl ketones has been developed. The addition of TFA was shown to improve the reaction yield and employing THF as solvent enabled the use of solid nitriles and in only a small excess. Using this method, five different benzoic acids reacted with a wide range of nitriles to produce 29 diverse (hetero)aryl ketone derivatives in up to 94% yield.
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| 3. |
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| 4. |
- Lindh, Jonas, et al.
(författare)
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Synthesis of styrenes by palladium(II)-catalyzed vinylation of arylboronic acids and aryltrifluoroborates by using vinyl acetate
- 2009
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Ingår i: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 15:18, s. 4630-4636
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Tidskriftsartikel (refereegranskat)abstract
- Reactions of aromatic and heteroaromatic boronic acids or aryltrifluoroborate salts with vinyl acetate in the presence of a palladium(II) catalyst give the corresponding styrenes in good yields. This Heck reaction proceeds with microwave heating in less than 30 min at 140 degrees C in the absence of base and tolerates a variety of substituents. No palladium reoxidant is needed and the vinylation is performed under non-inert conditions. Mass spectrometry (electrospray ionization mass spectrometry (ESIMS) and tandem mass spectrometry (MS/MS)) was used to identify cationic palladium-containing complexes in ongoing reactions. The key intermediates that have been detected, together with experiments that used deuterated vinyl acetate, support the existence of catalytically active palladium hydride species, and that it is the arylation of ethylene, not vinyl acetate, which generates the styrene product. The mechanism of the reaction is discussed in terms of the palladium(II) intermediates mentioned above.
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| 5. |
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| 6. |
- Sävmarker, Jonas, 1979-, et al.
(författare)
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Deoxybenzoins from Stille carbonylative cross-couplings using molybdenum hexacarbonyl
- 2010
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Ingår i: Tetrahedron Letters. - : Elsevier BV. - 0040-4039 .- 1359-8562. ; 51:52, s. 6886-6889
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Tidskriftsartikel (refereegranskat)abstract
- Stille-type carbonylative cross-couplings, employing palladium catalysis and Mo(CO)6 as the carbon monoxide carrier, were used for the preparation of deoxybenzoins. Straightforward transformations were conveniently performed in closed vessels at 100 C, providing the products in good yields. Benzyl bromides and chlorides were used as coupling partners with aryl and heteroaryl stannanes. This mild three-component carbonylation employs the destabilizing agent DBU to promote smooth release of carbon monoxide from Mo(CO)6, which made this protocol operationally simple and minimized the formation of Stille diarylmethane products.
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| 7. |
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| 8. |
- Agell, Jonas, et al.
(författare)
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Growth and the public sector : a reply
- 1999
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fölster and Henrekson (1998) claim that they, by addressing a number of econometric problems, can establish that it is likely that economies with a large public sector grow more slowly than economies with a small public sector. But their regressions are fundamentally flawed. Re-estimating their growth equation using theoretically valid instruments, we find that the growth effect of the public sector is statistically insignificant, and much smaller than the point-estimates reported by Fölster and Henrekson. This is consistent with the agnostic conclusion, drawn by us and many others, that cross-country growth regressions are unlikely to give a reliable answer to whether a large public sector is growth promoting or retarding.
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| 9. |
- Agell, Jonas, et al.
(författare)
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Growth and the public sector : A reply
- 1999
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Ingår i: European Journal of Political Economy. - 0176-2680 .- 1873-5703. ; 15:2, s. 359-366
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Tidskriftsartikel (refereegranskat)abstract
- Fölster and Henrekson [Fölster, S., Henrekson, M., 1999. Growth and the public sector: A critique of the critics. European Journal of Political Economy 15, 337–358] claim that, by addressing a number of econometric problems, they can establish that it is likely that economies with a large public sector grow more slowly than economies with a small public sector. But their regressions are fundamentally flawed. Re-estimating their growth equation using theoretically valid instruments, we find that the growth effect of the public sector is statistically insignificant, and much smaller than the point-estimates that they report. This is consistent with the agnostic conclusion, drawn by us and others, that cross-country growth regressions are unlikely to provide a reliable answer as to whether a large public sector is growth promoting or retarding.
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| 10. |
- Agell, Jonas, et al.
(författare)
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Growth and the public sector : A critical review essay
- 1997
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Ingår i: European Journal of Political Economy. - 0176-2680 .- 1873-5703. ; 13:1, s. 33-52
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Tidskriftsartikel (refereegranskat)abstract
- We review the theoretical and empirical evidence on the relation between growth and the public sector against the background of the current debate on the issue. The evidence is found to admit no conclusion on whether the relation is positive, negative or non-existent. A simple cross-country regression in an OECD sample illustrates how the relation is easily tilted from negative to positive by introducing control variables for initial GDP and the dependent population.
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