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Sökning: WFRF:(Lindner Juergen)

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1.
  • Ehrler, Jonathan, et al. (författare)
  • Magneto-structural correlations in a systematically disordered B2 lattice
  • 2020
  • Ingår i: New Journal of Physics. - : IOP PUBLISHING LTD. - 1367-2630. ; 22:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Ferromagnetism in certain B2 ordered alloys such as Fe(60)Al(40)can be switched on, and tuned, via antisite disordering of the atomic arrangement. The disordering is accompanied by a similar to 1 % increase in the lattice parameter. Here we performed a systematic disordering of B2 Fe(60)Al(40)thin films, and obtained correlations between the order parameter (S), lattice parameter (a(0)), and the induced saturation magnetization (M-s). As the lattice is gradually disordered, a critical point occurs at 1 -S= 0.6 anda(0)= 2.91 angstrom, where a sharp increase of theM(s)is observed. DFT calculations suggest that below the critical point the system magnetically behaves as it would still be fully ordered, whereas above, it is largely the increase ofa(0)in the disordered state that determines theM(s). The insights obtained here can be useful for achieving tailored magnetic properties in alloys through disordering.
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2.
  • George, Julie, et al. (författare)
  • Comprehensive genomic profiles of small cell lung cancer
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 524:7563, s. 47-U73
  • Tidskriftsartikel (refereegranskat)abstract
    • We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Dex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.
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3.
  • Iurchuk, Vadym, et al. (författare)
  • All-Electrical Operation of a Curie Switch at Room Temperature
  • 2023
  • Ingår i: Physical Review Applied. - : American Physical Society (APS). - 2331-7019. ; 20:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present all-electrical operation of a FexCr1-x-based Curie switch at room temperature. More specifically, we study the current-induced thermally driven transition from ferromagnetic to antiferromagnetic Magnetometry measurements at different temperatures show that the transition from the ferromagnetic to the antiferromagnetic coupling at zero field is observed at approximately 325 K. Analytical modeling confirms that the observed temperature-dependent transition from indirect ferromagnetic to indirect antiferromagnetic interlayer exchange coupling originates from the modification of the effective interlayer exchange constant through the ferromagnetic-to-paramagnetic transition in the Fe17.5Cr82.5 spacer with minor contributions from the thermally driven variations of the magnetization and magnetic anisotropy of the Fe layers. Room-temperature current-in-plane magnetotransport measurements on the patterned Fe/Cr/Fe17.5Cr82.5/Cr/Fe strips show the transition from the "low-resistance" parallel to the "highresistance" antiparallel remanent magnetization configuration, upon increased probing current density. Quantitative comparison of the switching fields, obtained by magnetometry and magnetotransport, confirms that the Joule heating is the main mechanism responsible for the observed current-induced resistive switching.
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4.
  • La Torre, Enrico, et al. (författare)
  • Local probe of irradiation-induced structural changes and orbital magnetism in Fe60Al40 thin films via an order-disorder phase transition
  • 2018
  • Ingår i: Physical Review B. - : AMER PHYSICAL SOC. - 2469-9950 .- 2469-9969. ; 98:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Hard x-ray absorption and magnetic circular dichroism spectroscopy have been applied to study the consequential changes of the local environment around Fe atoms and their orbital polarizations in 40 nm thick Fe60Al40 thin films along the order-disorder (B2 -> A2) phase transition initiated by 20-keV Ne+ ion irradiation with fluences of (0.75-6) x 10(14) ions cm(-2). The analysis of the extended x-ray absorption fine structure spectra measured at the Fe K edge at room temperature revealed an increased number of Fe-Fe nearest neighbors from 3.47(7) to 5.0(1) and similar to 1% of volume expansion through the transition. The visualization of the Fe and Al nearest-neighbor rearrangement in the first coordination shell of Fe absorbers via the transition was carried out by wavelet transformations. The obtained changes in Fe coordination are evidently reflected in the x-ray magnetic circular dichroism spectra which show an increased orbital magnetic moment of Fe atoms and a pronounced magnetic multielectronic excitations peak at similar to 60 eV above the edge. The amplitudes of both peaks demonstrated similar dependencies on the irradiation fluence. The results of self-consistent density functional calculations on relaxed Fe60Al40 model structures for the ordered (B2) and the disordered (A2) phases are consistent with the experimental findings and point to the formation of Fe-rich regions in the films studied.
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5.
  • Marazioti, Antonia, et al. (författare)
  • KRAS signaling in malignant pleural mesothelioma
  • 2022
  • Ingår i: EMBO Molecular Medicine. - : EMBO. - 1757-4684 .- 1757-4676. ; 14:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to death. MPM harbors loss-of-function mutations in BAP1, NF2, CDKN2A, and TP53, but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here, we show that a proportion of human MPM harbor point mutations, copy number alterations, and overexpression of KRAS with or without TP53 changes. These are likely pathogenic, since ectopic expression of mutant KRASG12D in the pleural mesothelium of conditional mice causes epithelioid MPM and cooperates with TP53 deletion to drive a more aggressive disease form with biphasic features and pleural effusions. Murine MPM cell lines derived from these tumors carry the initiating KRASG12D lesions, secondary Bap1 alterations, and human MPM-like gene expression profiles. Moreover, they are transplantable and actionable by KRAS inhibition. Our results indicate that KRAS alterations alone or in accomplice with TP53 alterations likely play an important and underestimated role in a proportion of patients with MPM, which warrants further exploration.
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6.
  • Menkveld, Albert J., et al. (författare)
  • Nonstandard Errors
  • 2024
  • Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
  • Tidskriftsartikel (refereegranskat)abstract
    • In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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