| 1. |
- Ribeiro, Barbara, et al.
(författare)
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Considering the dilemma of societal alignment: A response
- 2020
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The publication of our article “Introducing the dilemma of societal alignment for inclusive and responsible research and innovation” (Ribeiro et al., 2018) was accompanied by three commentaries (Guston, 2018; Nordmann, 2018; and Kuzma and Roberts, 2018). In the original article, we invoked Collingridge’s dilemma of the social control of technology to introduce a complementary dilemma of “societal alignment” in the governance of science, technology and innovation. Thoughtful and challenging critiques were presented in the three commentaries. In this paper, as completed in June 2019, we respond to those critiques and, in so doing, seek to further clarify and extend our arguments.
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| 2. |
- Ribeiro, Barbara, et al.
(författare)
-
Introducing the dilemma of societal alignment for inclusive and responsible research and innovation
- 2018
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Ingår i: Journal of Responsible Innovation. - : Informa UK Limited. - 2329-9460 .- 2329-9037. ; 5:3, s. 316-331
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Tidskriftsartikel (refereegranskat)abstract
- In this discussion paper, we outline and reflect on some of the key challenges that influence the development and uptake of more inclusive and responsible forms of research and innovation. Taking these challenges together, we invoke Collingridge’s famous dilemma of social control of technology to introduce a complementary dilemma that of ‘societal alignment’ in the governance of science, technology and innovation. Considerations of social alignment are scattered and overlooked among some communities in the field of science, technology and innovation policy. By starting to unpack this dilemma, we outline an agenda for further consideration of social alignment in the study of responsible research and innovation.
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| 3. |
- Zhao, Fei, et al.
(författare)
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C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3-and C5-Convertases
- 2019
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 10, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors. Here we characterized IgG autoantibodies derived from 33 patients with autoimmune C3 glomerulopathy. Serum antibodies from all 33 patients as well as purified IgGs bound to the in vitro assembled C3-convertase. Noteworthy, two groups of antibodies were identified: group 1 with strong (12 patients) and group 2 with weak binding C3-convertase autoantibodies (22 patients). C3Nef, as evaluated in a standard C3Nef assay, was identified in serum from 19 patients, which included patients from group 1 as well as group 2. The C3-convertase binding profile was independent of C3Nef. Group 1 antibodies, but not the group 2 antibodies stabilized the C3-convertase, and protected the enzyme from dissociation by Factor H. Also, only group 1 antibodies induced C3a release. However, both group 1 and group 2 autoantibodies bound to the C5-convertase and induced C5a generation, which was inhibited by monoclonal anti-C5 antibody Eculizumab in vitro. In summary, group 1 antibodies are composed of C3Nef and C5Nef antibodies and likely over-activate the complement system, as seen in hemolytic assays. Group 2 antibodies show predominantly C5Nef like activities and stabilize the C5 but not the C3-convertase. Altogether, these different profiles not only reveal a heterogeneity of the autoimmune forms of C3G (MPGN), they also show that in diagnosis of C3G not all autoimmune forms are identified and thus more vigorous autoantibody testing should be performed.
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