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- Kastbom, Alf, et al.
(författare)
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Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project)
- 2004
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 63:9, s. 1085-1089
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To evaluate the diagnostic sensitivity of antibodies to cyclic citrullinated peptide (CCP) in recent onset rheumatoid arthritis (RA) at diagnosis and 3 years later, and to evaluate anti-CCP antibody as a predictor of the disease course during 3 years. Methods: 242 patients with recent onset (≤ 1 year) RA were followed up regularly during 3 years after inclusion in the Swedish multicentre study "TIRA" 1996-98. Anti-CCP antibodies were analysed by an enzyme immunoassay (EIA). Rheumatoid factors (RFs) were analysed by latex agglutination and two isotype-specific (IgM and IgA) EIAs. Disease activity was assessed by plasma CRP, ESR, 28 joint disease activity score, and the physician's global assessment of disease activity. Functional ability was evaluated by the Health Assessment Questionnaire. Results: Overall, the diagnostic sensitivity of anti-CCP antibodies was 64% and the proportion of positive tests increased with the number of fulfilled classification criteria according to the American College of Rheumatology. The anti-CCP antibody results correlated with RF, but were better than RF as predictor of a more aggressive disease course. After 3 years 5/97 patients had changed anti-CCP status: 2 from negative to positive and 3 from positive to negative. The mean level of anti-CCP antibodies declined by 131 U/ml during the 3 year follow up (95% Cl 34 to 228 U/ml). Conclusion: The anti-CCP antibody assay has a similar diagnostic sensitivity to that of RF in early RA, but is better as a predictor of the disease course over 3 years. Although the mean serum level declines, anti-CCP antibody positivity remains essentially unaltered 3 years after diagnosis and start of antirheumatic treatment.
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- Lindroos, Alf, et al.
(författare)
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Late-orogenic Svecofennian deformation in SW Finland constrained by pegmatite emplacement ages
- 1996
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Ingår i: Terra Nova. - : Wiley. - 0954-4879 .- 1365-3121. ; 8:6, s. 567-574
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Tidskriftsartikel (refereegranskat)abstract
- Late stages of the Svecofennian orogeny in SW Finland were related to a tranpressional stress field and dextral movements along crustal scale shear zones under decreasing temperature and pressure conditions. In the Kemiö area, a minimum estimate for the time span of movements along one of these shear zones is obtained from the ages of 1840 to 1830 Myr-old microcline granite sheets, related to early ductile deformation, and by dating structurally late rare-mineral granite pegmatites, related to brittle deformation. One pegmatite was emplaced when the rheological conditions in the gabbro changed from ductile to semi-ductile and brittle. It has U-Pb ferrotapiolite ages ranging between 1807.0 ± 2.9 Myr (2 ) and 1803.1 + 2.9/ -2.0 Myr (2 ). Another pegmatite emplaced under brittle conditions has an U-Pb ferrotapiolite age of 1802.9 ± 1.3 Myr (2 ). These pegmatites were emplaced preferentially in gabbroic rocks, that showed brittle to semi-ductile deformation at a time when their more felsic host-rocks still showed ductile deformation. The age range bracketed by the microcline granite sheets and the structurally late pegmatites indicates that ductile deformation related to the transpressional Late Svecofennian tectonic regime in southwestern Finland, persisted for at least 30-40 Myr
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