| 1. |
- Thul, Peter J., et al.
(författare)
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A subcellular map of the human proteome
- 2017
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Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 356:6340
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Tidskriftsartikel (refereegranskat)abstract
- Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of the proteomes of 13 major organelles. Exploration of the proteomes revealed single-cell variations in abundance or spatial distribution and localization of about half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell.
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| 2. |
- Lindskog, Anders, et al.
(författare)
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The Cambrian–Ordovician succession at Lanna, Sweden : stratigraphy and depositional environments
- 2018
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Ingår i: Estonian Journal of Earth Sciences. - : Estonian Academy Publishers. - 1736-7557 .- 1736-4728. ; 67:2, s. 133-148
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Tidskriftsartikel (refereegranskat)abstract
- A ca 20 m thick succession of upper Furongian (Cambrian Stage 10) through Middle Ordovician (Darriwilian) strata exposed at Lanna, in the province of Närke, south-central Sweden, is described. The upper Furongian is represented by the Alum Shale Formation and reflects an overall shallowing trend that ultimately resulted in emergence above sea level and subaerial conditions. Hence, as in most other areas in south-central Sweden, the boundary between the Cambrian and the Ordovician is marked by a prominent disconformity and significant hiatus. In Närke, the hiatus spans the middle Stage 10 through the uppermost Tremadocian or lowermost Floian. The presence of stromatolites indicates quite shallow marine conditions during the latest Cambrian. The Ordovician succession is characterized by flatly bedded ‘orthoceratite limestone’, belonging to the ‘Latorp’, ‘Lanna’ and ‘Holen’ limestones (‘topoformations’). Widely varying microfacies characteristics in the ‘orthoceratite limestone’ suggest that the depositional environment underwent substantial changes through time, largely due to changes in sea level. A long-term trend of coarsening carbonate textures and more diverse fossil assemblages is seen upwards through the Ordovician succession. Cyclic microfacies patterns probably reflect high-frequency sea-level changes. Comparisons to other parts of Sweden and Baltoscandia reveal consistent patterns in the sedimentary development across a wide geographical area.
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| 3. |
- Lindskog, Anders, et al.
(författare)
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The Volkhov-Kunda transition and the base of the Holen Limestone at Kinnekulle, Västergötland, Sweden
- 2014
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Ingår i: GFF. - : Informa UK Limited. - 2000-0863 .- 1103-5897. ; 136:1, s. 167-171
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Tidskriftsartikel (refereegranskat)abstract
- The transition between the Volkhov and Kunda Baltoscandian stages (Darriwilian, Middle Ordovician) is associated with a notable sea-level fall. This study documents the lithologic and sedimentologic expression of this event in the orthoceratite limestone at the Hällekis quarry, Kinnekulle, Sweden. The uppermost Volkhov strata are characterized by abundant limonitic hardgrounds and relatively coarse carbonate textures, including intraclasts and ferruginous coated grains. The top of a conspicuous wacke-packstone interval is identified as the local Volkhov-Kunda and Lanna Limestone-Holen Limestone boundary. The boundary is overlain by marly limestone, in which limonitic hardgrounds become uncommon and a temporary fining of carbonate textures occurs. An overall trend of increasing (mainly skeletal) grain concentration and diversity is seen throughout the studied succession. Based on the collective observations, a sea-level curve for the upper Volkhov and lower Kunda is presented.
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