| 1. |
|
|
| 2. |
|
|
| 3. |
- Björksved, Margitha, 1964-, et al.
(författare)
-
Open vs closed surgical exposure of palatally displaced canines: a comparison of clinical and patient-reported outcomes-a multicentre, randomized controlled trial
- 2021
-
Ingår i: European Journal of Orthodontics. - : Oxford University Press (OUP). - 0141-5387 .- 1460-2210. ; 43:5, s. 487-497
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: To compare treatment time, patients' perceptions during orthodontic treatment, dental fear and side effects, between open and closed surgical exposures in patients with palatally displaced canines (PDCs). Trial design: Multicentre, randomized controlled trial, with random 1:1 allocation of two parallel groups. Materials and methods: One hundred and twenty patients from three different orthodontic centres were randomized into one of the two intervention arms, open or closed surgical exposure. Both techniques had mucoperiosteal flaps raised and bone removed above the PDCs. In open exposure, tissue was removed above the canine, and glass ionomer - reaching above soft tissue - was built on the crown. The canine was then left to erupt spontaneously, prior to orthodontic alignment. At closed exposure, a chain was bonded to the canine and orthodontic traction was applied under the mucosa until eruption. Orthodontic alignment of the canines was undertaken after eruption into the oral cavity, with fixed appliances in both groups. All participants were treated according to intention to treat (ITT). Blinding: Due to the nature of this trial, only outcome assessors could be blinded to the intervention group. Results: One hundred and seventeen patients completed the trial. All PDCs were successfully aligned. Total treatment time was equal in the two techniques, mean difference -0.1 months (95% CI -3.2 to 2.9, P = 0.93). The closed group experienced more pain and discomfort during the active orthodontic traction. Dental fear, root resorption and periodontal status did not show any clinically significant differences between the groups. Generalizability: Results of this randomized controlled trial (RCT) can be generalized only to a similar population aged 9-16 years, if exclusion criteria are met. Conclusion: The closed exposure group experienced more pain and discomfort mostly during active orthodontic traction. All other studied outcomes were similar between the two exposure groups.
|
|
| 4. |
|
|
| 5. |
- Cheng, Q., et al.
(författare)
-
Clinical epidemiology of Guillain-Barré syndrome in adults in Sweden 1996-97 : A prospective study
- 2000
-
Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 7:6, s. 685-692
-
Tidskriftsartikel (refereegranskat)abstract
- We described clinical manifestations, outcomes, prognostic indicators and clinico-epidemiological subgroups for 53 adult patients with Guillain-Barré syndrome (GBS) in Sweden during the period 1996-97. These patients were identified from a population of 2.8 million inhabitants and prospectively followed up for one year by a network of neurologists. An additional 10 cases, of whom five were adults who had not been prospectively followed up, were not included in the analyses. At 6 months after onset 80% of the patients could walk without aid, while at 1 year 46% were fully recovered, 42% had mild residual signs or symptoms, 4% had moderate and 6% severe disabilities, and 2% had died. Intravenous human immunoglobulin or plasmapheresis were used in 72% of the patients. The sum of the Medical Research Council (MRC) score at nadir was found as the only significant predictor for residual signs at 1 year in a multivariate model. Three subgroups, with different clinico-epidemiological characteristics, were identified by using cluster analysis. In conclusion, GBS in Sweden is frequently preceded by a respiratory infection, is often treated with immunomodulatory therapies, and exhibits a high recovery rate and a low fatality rate.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Josefsson, Eva, et al.
(författare)
-
A qualitative study of the influence of poor dental aesthetics on the lives of young adults
- 2010
-
Ingår i: Acta Odontologica Scandinavica. - Amsterdam : Informa UK Limited. - 0001-6357 .- 1502-3850. ; 68:1, s. 19-26
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Although many countries offer some publicly funded orthodontic treatment for children, not all conditions receive treatment and some adolescents enter adulthood with persisting poor dental aesthetics or malocclusions. The aim of this study was to generate a theory highlighting the main concerns of young adults, either native-born or of immigrant background, with poor dental aesthetics and the measures they adopt to manage their condition in everyday life.Material and methods: A qualitative method, classic grounded theory, was applied in order to generate a substantive theory highlighting the main concerns and managing mechanisms of 13 strategically selected 19- and 20-year-olds with poor dental aesthetics. Open interviews were conducted with each participant, the topics covering different aspects of social and dental conditions.Results: A core category and three conceptual categories were generated. The core category was labelled "Being under the pressure of social norms" and was related to categories explaining three different ways in which these young adults handle their main concern: (1) avoiding showing their teeth; (2) minimizing the importance of appearance; and (3) seeking orthodontic treatment. The theory offers the potential for improved understanding of young adults who, despite poor dental aesthetics, are managing well with life, and also of those who have not adjusted well.Conclusions: In early adolescence it may be problematic to make decisions about orthodontic treatment. Undisclosed dental fear can be an important barrier. Some of the young adults in the present study would probably benefit from treatment.
|
|
| 9. |
- Lindsten, R, et al.
(författare)
-
Pacifier-sucking and breast-feeding : a comparison between the 1960 s and the 1990 s.
- 2009
-
Ingår i: Journal of dentistry for children (Chicago, Ill.). - 1551-8949. ; 76:3, s. 199-203
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Pacifiers and their forerunners have been condemned in past centuries, probably beginning in the 17(th) and 18(th) centuries when alcohol and opiates were incorporated as fillings in sucking rags in Great Britain. Nowadays, the modern pacifier is criticized for reducing breast-feeding time and encouraging weaning. The purpose of this study was to analyze if pacifier-sucking has been detrimental to breast-feeding in the past few decades.METHODS: In the present study, 2 groups of young children born 30 years apart (1967 and 1995 to 1997) in the same geographic area were analyzed in the first 6 months of age regarding their sucking and feeding habits, including initial and prolonged pacifier-sucking and breast-feeding.RESULTS: Findings do not support the commonly held opinion that pacifier-sucking reduces breast-feeding time. In the 30 years that separate the 2 groups, the pacifier-sucking habit increased by 32% and prolonged use of a pacifier increased. At the same time, breast-feeding at 6 months old has increased 20-fold in the contemporary group (born between 1995 and 1997) as compared with the 1967 group.CONCLUSIONS: The results suggest that mothers might be unable to satisfy their child's sucking urge through breast-feeding alone, and that they use the pacifier as a supplement. Pacifier use does not negatively affect the prevalence of breast-feeding.
|
|
| 10. |
- Rawcliffe, Denise F. R., et al.
(författare)
-
The High Level of Aberrant Splicing of ISCU in Slow-Twitch Muscle May Involve the Splicing Factor SRSF3
- 2016
-
Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 11:10
-
Tidskriftsartikel (refereegranskat)abstract
- Hereditary myopathy with lactic acidosis (HML) is an autosomal recessive disease caused by an intronic one-base mutation in the iron-sulfur cluster assembly (ISCU) gene, resulting in aberrant splicing. The incorrectly spliced transcripts contain a 100 or 86 bp intron sequence encoding a non-functional ISCU protein, which leads to defects in several Fe-S containing proteins in the respiratory chain and the TCA cycle. The symptoms in HML are restricted to skeletal muscle, and it has been proposed that this effect is due to higher levels of incorrectly spliced ISCU in skeletal muscle compared with other energy-demanding tissues. In this study, we confirm that skeletal muscle contains the highest levels of incorrect ISCU splice variants compared with heart, brain, liver and kidney using a transgenic mouse model expressing human HML mutated ISCU. We also show that incorrect splicing occurs to a significantly higher extent in the slow-twitch soleus muscle compared with the gastrocnemius and quadriceps. The splicing factor serine/arginine-rich splicing factor 3 (SRSF3) was identified as a potential candidate for the slow fiber specific regulation of ISCU splicing since this factor was expressed at higher levels in the soleus compared to the gastrocnemius and quadriceps. We identified an interaction between SRSF3 and the ISCU transcript, and by overexpressing SRSF3 in human myoblasts we observed increased levels of incorrectly spliced ISCU, while knockdown of SRSF3 resulted in decreased levels. We therefore suggest that SRSF3 may participate in the regulation of the incorrect splicing of mutant ISCU and may, at least partially, explain the muscle-specific symptoms of HML.
|
|
