| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Skantzakis, E., et al.
(författare)
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Non-linear Extreme Ultraviolet Applications with Attosecond Pulses
- 2024
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Ingår i: Topics in Applied Physics. - 1437-0859 .- 0303-4216. - 9783031554629 - 9783031554636 ; 151, s. 1-24
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Bokkapitel (refereegranskat)abstract
- In recent years laser driven attosecond sourcesAttosecond sources based on loose geometry high order harmonic generationHigh order harmonic generation reach focused intensities as high as to induce multi-photonMulti-photonmultiple ionizationMultiple ionization or even strong -field effectsEven strong-field effects in the extreme ultraviolet spectral range. In this chapter, we review four such sources developed through collaborative efforts between FORTH, ELI-ALPS and the University of Lund together with recent results obtained in the above mentioned topics utilizing these sources.
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| 3. |
- Makos, I, et al.
(författare)
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Α 10-gigawatt attosecond source for non-linear XUV optics and XUV-pump-XUV-probe studies
- 2020
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- The quantum mechanical motion of electrons and nuclei in systems spatially confined to the molecular dimensions occurs on the sub-femtosecond to the femtosecond timescales respectively. Consequently, the study of ultrafast electronic and, in specific cases, nuclear dynamics requires the availability of light pulses with attosecond (asec) duration and of sufficient intensity to induce two-photon processes, essential for probing the intrinsic system dynamics. The majority of atoms, molecules and solids absorb in the extreme-ultraviolet (XUV) spectral region, in which the synthesis of the required attosecond pulses is feasible. Therefore, the XUV spectral region optimally serves the study of such ultrafast phenomena. Here, we present a detailed review of the first 10-GW class XUV attosecond source based on laser driven high harmonic generation in rare gases. The pulse energy of this source largely exceeds other laser driven attosecond sources and is comparable to the pulse energy of femtosecond Free-Electron-Laser (FEL) XUV sources. The measured pulse duration in the attosecond pulse train is 650 ± 80 asec. The uniqueness of the combined high intensity and short pulse duration of the source is evidenced in non-linear XUV-optics experiments. It further advances the implementation of XUV-pump-XUV-probe experiments and enables the investigation of strong field effects in the XUV spectral region.
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| 4. |
- Gunja, Sethu Madhava Rao, 1986-, et al.
(författare)
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Transcriptome analysis of human patients with telomere biology disorders having mutations in PARN gene
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Poly(A)-specific ribonuclease (PARN) is a eukaryotic deadenylating enzyme that removes poly(A) tails of RNAs, including mRNAs and ncRNAs. Mutations in human PARN are associated with developmental delay and telomere biology disorders. We have previously described a group of human patients with mutations in PARN that presented heterogeneity in disease phenotypes. Here, we have characterized the transcriptome of these patients by investigating the differential gene expression to identify metabolic pathways that were affected in these patients. Patients with lesions in PARN were all affected in the same metabolic pathways: ribosome/translation, cell-cell adhesion and cell signaling pathways. This suggests that these pathways could be crucial for the development of a severe disease state and influence penetrance of the disease. We also identified major defects in snoRNAs, scaRNAs and miRNAs profiles. Interestingly a miRNA cluster miR-let7c/miR99a/miR-125b was affected in one patient. This miRNA cluster has anti-tumorigenic properties, suggesting that deficiency of PARN could result in the development of cancer. Overall, this study has identified metabolic pathways that are affected in PARN deficient patients. The identified pathways could play a role in development of TBDs.
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