| 1. |
- Makafe, Gaelle G., et al.
(författare)
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Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
- 2019
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Ingår i: Cell Chemical Biology. - : CELL PRESS. - 2451-9456 .- 2451-9448. ; 26:8, s. 1187-
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Tidskriftsartikel (refereegranskat)abstract
- There is a great need for identification and development of new anti-tuberculosis drugs with novel targets. Recent drug-discovery efforts typically focus on identifying inhibitors but not activators that perturb metabolic enzymes' functions as a means to kill Mycobacterium tuberculosis (Mtb). Here, we describe a class of quinoline compounds, Z0933/Z0930, which kill Mtb by acting as activators of glutamate kinase (GK), a previously untargeted enzyme catalyzing the first step of proline biosynthesis. We further show that Z0933/Z0930 augment proline production and induce Mtb killing via proline-derived redox imbalance and production of reactive oxygen species. This work highlights the effectiveness of gain-of-function probes against Mtb and provides a framework for the discovery of next-generation allosteric activators of GK.
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| 2. |
- Liu, Yi, et al.
(författare)
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Porous, robust, thermally stable, and flame retardant nanocellulose/polyimide separators for safe lithium-ion batteries
- 2023
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 11:43, s. 23360-23369
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Tidskriftsartikel (refereegranskat)abstract
- The safety of lithium-ion batteries (LIBs) is paramount for all users. One effective way to improve safety is incorporating heat-resistant polyimide (PI) separators, which can increase the thermal stability of batteries and minimize the risk of thermal runaway. However, preparing PI separators with both an ideal pore structure and adequate mechanical properties remains as a challenge. Here, we introduced decabromodiphenyl ethane (DBDPE) and cellulose nanofibers (CNFs) into PI and produced a hybrid separator with an outstanding pore structure and excellent mechanical properties. Aided with DBDPE, the separators attain a well-defined and uniform pore size (20 nm), while demonstrating high porosities (78%) through phase inversion processes. Owing to the addition of CNFs, the mechanical properties of the separators were significantly improved, with a tensile strength of 25.4 MPa and an elastic modulus of 550.1 MPa. Moreover, the separators demonstrate high ion conductivity (0.45 mS cm-1), excellent thermal-dimensional stability (up to 200 degrees C), remarkable flame retardancy, and outstanding electrolyte wettability. At room temperature, the batteries with the separators demonstrate comparable performance with those of polypropylene (PP) separators. However, when subjected to thermal shock treatments, the batteries with the separators outperform those with PP, showcasing their superior performance. The work introduces a novel strategy for designing high-performance separators, thereby paving the way for advancements in the fabrication of LIBs with enhanced safety features. A porous, robust, and thermally stable hybrid separator was developed to solve the dilemma between desired pore structures and mechanical properties in polyimide separators by introducing decabromodiphenyl ethane and cellulose nanofibers.
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| 3. |
- Chen, Kai, et al.
(författare)
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Room-temperature multiferroic properties in NiBi2O4
- 2010
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Ingår i: Europhysics letters. - : European Physical Society. - 0295-5075 .- 1286-4854. ; 89:2
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Tidskriftsartikel (refereegranskat)abstract
- Magnetism and ferroelectricity at room temperature are observed in the NiBi2O4 ceramics. Both the time reversal and the inversion symmetry of the structure (space group F-43m) are broken. The saturation magnetization is 0.028 emu/g and the saturation polarization 2P(s) similar to 4.0 mu C/cm(2). NiBi2O4 also shows other room-temperature multiferroic properties, e. g. the piezoelectric coefficient (d(33)), the polarized dielectric character, the magneto-dielectric response and the magnetoelectric effect. Copyright (C) EPLA, 2010
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| 4. |
- Chiaraviglio, Luca, et al.
(författare)
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5G in rural and low-income areas : Are we ready?
- 2016
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Ingår i: PROCEEDINGS OF THE 2016 ITU KALEIDOSCOPE ACADEMIC CONFERENCE - ICTS FOR A SUSTAINABLE WORLD (ITU WT). - Piscataway, NJ : IEEE. - 9789261204518 ; , s. 99-106
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Konferensbidrag (refereegranskat)abstract
- Current trends in telecommunication networks foresee the adoption of the,fifth generation (5G) of wireless networks in the near fixture. However; a large number of people are living without coverage and connectivity. To face this issue, we consider the possibility of deploying 5G networks in rural and low-income zones. After detailing the current state-of-the-art, we consider the main challenges that need to be faced. Moreover; we define the main pillars to follow in order to deploy 5G networks in such zones, as well as a proposal of a future network architecture.
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| 5. |
- Chiaraviglio, Luca, et al.
(författare)
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Bringing 5G into Rural and Low-Income Areas : Is It Feasible?
- 2017
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Ingår i: IEEE Communications Standards Magazine. - : Institute of Electrical and Electronics Engineers (IEEE). - 2471-2825. ; 1:3, s. 50-57
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Tidskriftsartikel (refereegranskat)abstract
- Nowadays, at least two billion people are experiencing a complete lack of wireless cellular network coverage. These users live in rural areas and low-income regions, where network operators are not keen to invest, mainly due to high capital expenditure and operational expenditure costs, as well as the scarcity of electricity from the grid. We tackle this challenge by proposing a 5G network explicitly designed to serve rural and low-income areas. Our solution investigates the possibility of mounting remote radio heads on top of unmanned aerial vehicles, as well as large cells (LCs) to increase the coverage range. In addition, 5G nodes are powered by solar panels and batteries. Preliminary results, obtained over three representative case studies located in Italy, Cook Islands, and Zimbabwe, show that providing connectivity in rural and low-income areas by means of the proposed 5G architecture is feasible. At the same time, we also show that the monthly subscription fee paid by the users can be kept sufficiently low, that is, less than €1/month in low-income areas, and around €11/month in rural regions.
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| 6. |
- Jiang, Yan, et al.
(författare)
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Negligible-Pb-Waste and Upscalable Perovskite Deposition Technology for High-Operational-Stability Perovskite Solar Modules
- 2019
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Ingår i: Advanced Energy Materials. - : Wiley-VCH Verlagsgesellschaft. - 1614-6832 .- 1614-6840. ; 9:13
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Tidskriftsartikel (refereegranskat)abstract
- An upscalable perovskite film deposition method combining raster ultrasonic spray coating and chemical vapor deposition is reported. This method overcomes the coating size limitation of the existing stationary spray, single-pass spray, and spin-coating methods. In contrast with the spin-coating method (>90% Pb waste), negligible Pb waste during PbI2 deposition makes this method more environmentally friendly. Outstanding film uniformity across the entire area of 5 cm x 5 cm is confirmed by both large-area compatible characterization methods (electroluminescence and scattered light imaging) and local characterization methods (atomic force microscopy, scanning electron microscopy, photoluminescence mapping, UV-vis, and X-ray diffraction measurements on multiple sample locations), resulting in low solar cell performance decrease upon increasing device area. With the FAPb(I0.85Br0.15)(3) (FA = formamidinium) perovskite layer deposited by this method, champion solar modules show a power conversion efficiency of 14.7% on an active area of 12.0 cm(2) and an outstanding shelf stability (only 3.6% relative power conversion efficiency decay after 3600 h aging). Under continuous operation (1 sun light illumination, maximum power point condition, dry N-2 atmosphere with <5% relative humidity, no encapsulation), the devices show high light-soaking stability corresponding to an average T-80 lifetime of 535 h on the small-area solar cells and 388 h on the solar module.
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| 7. |
- Liu, Jinsong, et al.
(författare)
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Coupled transport/reaction modelling of copper canister corrosion aided by microbial processes
- 2004
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Ingår i: Radiochimica Acta. - : Walter de Gruyter GmbH. - 0033-8230 .- 2193-3405. ; 92:11-sep, s. 849-854
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Tidskriftsartikel (refereegranskat)abstract
- Copper canister corrosion is an important issue in the concept of a nuclear fuel repository. Previous studies indicate that the oxygen-free copper canister could hold its integrity for more than 100 000 years in the repository environment. Microbial processes may reduce sulphate to sulphide and considerably increase the amount of sulphide available for corrosion. In this paper. a coupled transport/reaction model is developed to account for the transport of chemical species produced by microbial processes. The corroding agents like sulphide would come not only from the intruding groundwater, but also from the reduction of sulphate near the canister. The reaction of sulphate-reducing bacteria and the transport of sulphide in the bentonite buffer is included in the model. The local depth of copper canister corrosion is calculated by the model.
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| 8. |
- Lu, Yuqian, et al.
(författare)
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Outlook on human-centric manufacturing towards Industry 5.0
- 2022
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 62, s. 612-627
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Tidskriftsartikel (refereegranskat)abstract
- The recent shift to wellbeing, sustainability, and resilience under Industry 5.0 has prompted formal discussions that manufacturing should be human-centric - placing the wellbeing of industry workers at the center of manufacturing processes, instead of system-centric - only driven by efficiency and quality improvement and cost reduction. However, there is a lack of shared understanding of the essence of human-centric manufacturing, though significant research efforts exist in enhancing the physical and cognitive wellbeing of operators. Therefore, this position paper presents our arguments on the concept, needs, reference model, enabling technologies and system frameworks of human-centric manufacturing, providing a relatable vision and research agenda for future work in human-centric manufacturing systems. We believe human-centric manufacturing should ultimately address human needs defined in an Industrial Human Needs Pyramid - from basic needs of safety and health to the highest level of esteem and self-actualization. In parallel, human-machine relationships will change following a 5C evolution map - from current Coexistence, Cooperation and Collaboration to future Compassion and Coevolution. As such, human-centric manufacturing systems need to have bi-directional empathy, proactive communication and collaborative intelligence for establishing trustworthy human-machine coevolution relationships, thereby leading to high-performance human-machine teams. It is suggested that future research focus should be on developing transparent, trustworthy and quantifiable technologies that provide a rewarding working environment driven by real-world needs.
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| 9. |
- Sun, Jing, et al.
(författare)
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VLBI observations to the APOD satellite
- 2018
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Ingår i: Advances in Space Research. - : Elsevier BV. - 1879-1948 .- 0273-1177. ; 61:3, s. 823-829
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Tidskriftsartikel (refereegranskat)abstract
- The APOD (Atmospheric density detection and Precise Orbit Determination) is the first LEO (Low Earth Orbit) satellite in orbit co-located with a dual-frequency GNSS (GPS/BD) receiver, an SLR reflector, and a VLBI X/S dual band beacon. From the overlap statistics between consecutive solution arcs and the independent validation by SLR measurements, the orbit position deviation was below 10 cm before the on-board GNSS receiver got partially operational. In this paper, the focus is on the VLBI observations to the LEO satellite from multiple geodetic VLBI radio telescopes, since this is the first implementation of a dedicated VLBI transmitter in low Earth orbit. The practical problems of tracking a fast moving spacecraft with current VLBI ground infrastructure were solved and strong interferometric fringes were obtained by cross-correlation of APOD carrier and DOR (Differential One-way Ranging) signals. The precision in X-band time delay derived from 0.1 s integration time of the correlator output is on the level of 0.1 ns. The APOD observations demonstrate encouraging prospects of co-location of multiple space geodetic techniques in space, as a first prototype.
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| 10. |
- Zhao, Jinsong, et al.
(författare)
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Identification of the Nature of Electromagnetic Waves near the Proton-cyclotron Frequency in Solar-terrestrial Plasmas
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 890:1
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Tidskriftsartikel (refereegranskat)abstract
- Low-frequency (quasi-)monochromatic electromagnetic waves near the ion-cyclotron frequency always exhibit both left-hand (LH) and right-hand (RH) polarization in solar-terrestrial spacecraft observations. However, due to the Doppler frequency shift resulting from the bulk flow of charged particles, the nature of these waves in the plasma frame is still unclear. This paper proposes a useful method to directly identify the nature of the observed waves. Using three wave parameters including polarization, direction of the parallel Poynting flux, and correlation between perpendicular magnetic field and perpendicular ion/electron velocity, we could discriminate the wave mode (Alfven/ion-cyclotron wave or fast-magnetosonic/whistler wave) and its propagation direction (along or against the magnetic field) in the plasma frame. Using Magnetospheric Multiscale spacecraft measurements, we analyze two wave events containing both LH- and RH-polarized low-frequency electromagnetic waves in the Earth's magnetosheath, and find that these waves correspond to counter-propagating Alfven/ion-cyclotron waves in the plasma frame. Our method is helpful for studying low-frequency electromagnetic waves detected by satellites that have particle measurements with an adequate temporal resolution.
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