| 1. |
- Li, Yifei, et al.
(författare)
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Can Nup88 expression be associated with atypical endometrial hyperplasia and endometrial cancer? A preliminary study
- 2016
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Ingår i: Pathology, Research and Practice. - : ELSEVIER GMBH, URBAN & FISCHER VERLAG. - 0344-0338 .- 1618-0631. ; 212:4, s. 274-278
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nup88 is overexpressed in a number of types of carcinomas and is associated with myometrial invasion, but its exact expression pattern in endometrial cancer and premalignant lesions is unknown. Aims: To evaluate the role of Nup88 in endometrial cancers and atypical endometrial hyperplasia and its clinicopathological significance. Methods: Nup88 expression was examined by immunohistochemistry in samples from 104 endometrial cancers, 21 atypical endometrial hyperplasia lesions, and 40 normal endometria. All samples were from patients who underwent surgery at the First Hospital of Hebei Medical University (Shijiazhuang, China) between April 2006 and December 2009. Nup88 expression was compared between the groups and associations were assessed between Nup88 and clinicopathological characteristics of the subjects. Results: Nup88 expression in cancer (76% of samples) and atypical hyperplasia (91%) was significantly higher compared to normal endometrium (33%, both P < 0.001), but there was no significant difference between endometrial cancer and atypical hyperplasia (P = 0.237). The expression of Nup88 increased significantly with increasing exposure time to estrogen (P = 0.033). Conclusions: Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions. Nup88 might be a useful biomarker for pre-malignant lesions and early-stage endometrial cancer. (C) 2016 Elsevier GmbH. All rights reserved.
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| 2. |
- Liu, Ya, 1991, et al.
(författare)
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Egg albumen templated graphene foams for high-performance supercapacitor electrodes and electrochemical sensors
- 2018
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 6:37, s. 18267-18275
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate a simple and scalable strategy to obtain N, S and Si co-doped biocompatible graphene foams (GFs) with different shapes using egg albumen as the template. The unique porous structure and element doping endow the GFs with a high charge-discharge rate and good wettability, which largely improve the electrochemical performance of the electrodes, including ultrahigh specific capacitance (534 F g-1at 1 A g-1), and excellent rate capability (308 F g-1at 100 A g-1) and cycling performance (96.1% retention of the initial capacitance after 10000 cycles at a high current density of 10 A g-1). Besides, when used as an electrochemical sensor for dopamine, the GF exhibits a detection limit as low as 1.2 μM with a linear response up to 70 μM, due to the low equivalent series resistance. These reveal great potential for promoting the application of 3D graphene in energy storage and electrochemical sensors.
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| 3. |
- Long, Doudou, et al.
(författare)
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Improving texture and microstructure homogeneity in high-purity ta sheets by warm cross rolling and annealing
- 2021
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Ingår i: Metals. - : MDPI AG. - 2075-4701. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- The evolution of texture and microstructure uniformity in high-purity tantalum (Ta) sheets during 135◦ warm cross rolling (WCR) was analyzed in detail. X-ray diffraction suggested that relatively uniform ‘ideal’ deformation texture distribution across the thickness could be obtained from WCR, since more potential slip systems could be activated. Electron backscatter diffraction (EBSD) results indicated that the change in strain path in warm rolling could enhance dislocations mobility and increase the probability of dislocations rearrangement and annihilation. Thus, the proportion of low-angle grain boundaries was significantly reduced, and more sub-grain boundaries or sub-grains were formed via WCR. The calculation of geometrically necessary dislocation density based on the strain gradient model supports this result. The analysis of relative Schmid factor combined with the strain contouring map indicated that inhomogeneous orientation-dependent grain subdivision could be effectively weakened, and relatively uniform strain distribution could be formed in the WCR sample. Upon annealing, uniform fine grain size and more randomly oriented grains were obtained in the WCR sample after the completion of recrystallization because of relatively uniform grain subdivision and stored energy distribution.
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| 4. |
- Qi, Jing, et al.
(författare)
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Levels, distribution, childhood exposure assessment, and influencing factors of polybrominated diphenyl ethers (PBDEs) in household dust from nine cities in China
- 2023
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 874
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Tidskriftsartikel (refereegranskat)abstract
- Household dust is an important source of premature exposure to polybrominated diphenyl ethers (PBDEs), especially for children. In this onsite study, 246 dust samples were collected from 224 households in nine Chinese cities during 2018–2019. Questionnaires were administered to explore the association between household-related information and PBDEs in household dust. The median concentration of Σ12PBDEs in household dust from 9 cities was 138 ng/g (94–227 ng/g), with the arithmetic mean of 240 ± 401 ng/g. Among the nine cities, the highest median concentration of Σ12PBDEs in household dust was found in Mianyang (295.57 ng/g), while the lowest was found in Wuxi (23.15 ng/g). BDE-71 was the most dominant congener, ranging from 42.08 % to 98.15 % of the 12 PBDE congeners among 9 cities. Three potential sources for the indoor environment were Penta-BDE, Octa-BDE commercial products, and photolytic bromine from Deca-BDEs based on the largest contribution (81.24 %). Under the moderate exposure scenario, the exposure levels through ingestion and dermal absorption for children were 7.30 × 10−1 ng/kg BW/day and 3.26 × 10−2 ng/kg BW/day, respectively. Temperature, CO2, years of residence, income, family size, household size, use of computers, heating, use of insecticide, and use of humidifiers were influential factors for PBDE concentrations in household dust. Based on the evidence of the correlation between PBDEs and these household parameters, it can be applied to reduce PBDE concentrations in household dust, which is a basis for controlling PBDEs pollution in Chinese households and protecting population health.
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| 5. |
- Wang, Xinqi, et al.
(författare)
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Levels, distribution, sources and children health risk of PAHs in residential dust : A multi-city study in China
- 2023
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Ingår i: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 862
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Tidskriftsartikel (refereegranskat)abstract
- Background: Polycyclic aromatic hydrocarbons (PAHs) are typical residential pollutants mainly from biofuel combustion that impose inevitable risk to children. The PAHs in residential dust is universal in most Chinese households with an obvious public health concern.Methods: In this observational study, a total of 235 residential dust samples from 8 Chinese cities (Panjin, Shijiazhuang, Lanzhou, Luoyang, Xi'an, Wuxi, Mianyang, and Shenzhen) were collected from April 2018 to March 2019, which were extracted and analyzed for 16 priority PAHs by HPLC/FD-UV. Diagnostic ratios, hierarchical clustering analysis and principal component analysis were applied simultaneously for source apportionments. Incremental lifetime cancer risk was employed to estimate children's health risks based on the assumed exposure scenarios. Spearman correlation, Mann-Whitney U test, Kruskal-Wallis H test and Partial Least Squares were used to screen the factors affecting the concentration of PAHs in residential dust.Results: The median concentration of ∑16PAHs in residential dust from 8 cities was 44.11 μg/g (0.04 - 355.79 μg/g). ∑16PAHs were found both higher in dust samples in heating season and from downwind households only in Mianyang (p < 0.05). The leading two sources of PAHs were combustion processes and automobile exhaust emissions based on four principal components that accounted for 74.29 % of the total variance. Indoor air environmental factors, household characteristics, and residents' behavioral lifestyles may be the influencing factors of residential dust PAHs. The carcinogenic risk of children aged 0 - 5 years, under the moderate exposure level of PAHs in residential dust, exceeded the acceptable level (10−5 - 10−4 for dermal contact and 10−6 - 10−5 for ingestion).Conclusions: There was serious PAHs pollution in residential dust under actual living conditions in eight cities across China. More evidence-based measures were needed to control PAHs pollution to safeguard children's health according to appointed sources and influencing factors in residential dust.
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| 6. |
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| 7. |
- Zhang, Xiaoli, et al.
(författare)
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Hybrid Perovskite Light-Emitting Diodes Based on Perovskite Nanocrystals with Organic-Inorganic Mixed Cations
- 2017
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Ingår i: Advanced Materials. - : WILEY-V C H VERLAG GMBH. - 0935-9648 .- 1521-4095. ; 29:18
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Tidskriftsartikel (refereegranskat)abstract
- Organic-inorganic hybrid perovskite materials with mixed cations have demonstrated tremendous advances in photovoltaics recently, by showing a significant enhancement of power conversion efficiency and improved perovskite stability. Inspired by this development, this study presents the facile synthesis of mixed-cation perovskite nanocrystals based on FA((1-x))Cs(x)PbBr(3) (FA = CH(NH2)(2)). By detailed characterization of their morphological, optical, and physicochemical properties, it is found that the emission property of the perovskite, FA((1-x))Cs(x)PbBr(3), is significantly dependent on the substitution content of the Cs cations in the perovskite composition. These mixed-cation perovskites are employed as light emitters in light-emitting diodes (LEDs). With an optimized composition of FA(0.8)Cs(0.2)PbBr(3), the LEDs exhibit encouraging performance with a highest reported luminance of 55 005 cd m(-2) and a current efficiency of 10.09 cd A(-1). This work provides important instructions on the future compositional optimization of mixed-cation perovskite for obtaining high-performance LEDs. The authors believe this work is a new milestone in the development of bright and efficient perovskite LEDs.
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| 8. |
- Zhu, Jialin, et al.
(författare)
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Asymmetric cross rolling : A new technique for alleviating orientation-dependent microstructure inhomogeneity in tantalum sheets
- 2020
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Ingår i: Journal of Materials Research and Technology. - : Elsevier BV. - 2238-7854. ; 9:3, s. 4566-4577
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Tidskriftsartikel (refereegranskat)abstract
- New rolling technique, i.e. asymmetric rolling combined with cross rolling is adopted to produce Ta sputtering targets in this study. Electron backscatter diffraction (EBSD) analysis suggests that (111) and (100) deformed grains distribute alternately along normal direction in cross rolling (CR) and asymmetric cross rolling (ACR) samples. Misorientation angle distribution indicates that severe orientation-dependent grain fragmentation exists in the CR sample, which is also confirmed by kernel average misorientation and grain reference orientation deviation-hyper. Grain average misorientation (GAM) and distribution of geometrically necessary dislocations (GNDs) suggest that the effect of increasing shear strain introduced by asymmetric rolling on deformation microstructure is mainly reflected in the (100) grains, which is further verified by orientation-dependent microhardness values. The computation of Schmid factor indicates that slip within (100) grains in the ACR sample is easier, and the system with higher Schmid factor can alone accommodate the majority of plastic strain. Transmission electron microscopy (TEM) reveals that dense dislocation walls (DDWs) are formed within the (100) deformed grains in the ACR sample, while only sparse dislocation lines can be observed in the CR sample. X-ray line profile analysis (XLPA) displays that ACR can significantly increase the stored energy of the (100) deformed grains and thus weaken the orientation-dependent stored energy distribution. The enhanced recrystallization ability of the (100) grains in the ACR sample facilitates homogenization of the annealing microstructure.
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| 9. |
- Zhu, Jialin, et al.
(författare)
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Strain dependence of deformation and recrystallization microstructure homogeneity in clock-rolled tantalum sheets
- 2020
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Ingår i: Materials Characterization. - : Elsevier BV. - 1044-5803. ; 161
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Tidskriftsartikel (refereegranskat)abstract
- Microstructure and crystallographic texture are the key factors that determine the sputtering target properties. Clock rolling plays an important role in improving the microstructure homogeneity, but the effect of strain during rolling on deformation and recrystallization behavior is not clear. Thus, high-purity tantalum (Ta) plates were 135° clock rolled to 70% and 87% reduction and then annealed at various temperatures to observe the microstructure evolution. Texture and microstructure in the center layer of the rolled and annealed Ta sheets were characterized via optical microscope (OM), X-ray diffraction (XRD), electron backscatter diffracting (EBSD) and transmission electron microscope (TEM). The results displayed that significant microstructure difference existed between 70% and 87% sample. Grain average misorientation value of {111} grains {〈111〉//normal direction (ND)} in the 70% sample was considerably higher than that in the 87% sample, suggesting a more heterogeneous grain fragmentation. Schmid factor (SFrolling) and Taylor model analysis of {111} grains in the 70% sample demonstrated that the slip was easier, and the system with higher SFrolling could alone accommodate the majority of plastic strain, contributing to the formation of micoshear bands. Upon annealing, the sample rolled 70% recrystallized more quickly, owing to strong {111} deformed texture, and severe microstructure subdivision and great stored energy within {111} grains. The {111} texture is very strong and grain size distribution was not uniform after the completion of recrystallization. However, after annealing of sample rolled 87%, smaller average grain size and variation, and relatively homogeneous texture distribution can be obtained.
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| 10. |
- Basu, Samar, et al.
(författare)
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Evidence for Time-dependent Maximum Increase ofFree Radical Damage and Eicosanoid Formation in theBrain as Related to Duration of Cardiac Arrest andCardio-pulmonary Resuscitation
- 2003
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Ingår i: Free radical research. - : Informa UK Limited. - 1071-5762 .- 1029-2470. ; 37:3, s. 251-256
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Tidskriftsartikel (refereegranskat)abstract
- Recovery of neurological function in patients following cardiac arrest and cardiopulmonary resuscitation (CPR) is a complex event. Free radical induced oxidative stress is supposed to be involved in this process. We studied levels of 8-iso-PGF2alpha (indicating oxidative injury) and 15-keto-dihydro-PGF2alpha (indicating inflammatory response) in venous plasma obtained from the jugular bulb in a porcine model of experimental cardiopulmonary resuscitation (CPR) where 2, 5, 8, 10 or 12 min of ventricular fibrillation (VF) was followed by 5 or 8 min of closed-chest CPR. A significant increase of 8-iso-PGF2alpha was observed immediately following restoration of spontaneous circulation in all experiments of various duration of VF and CPR. No such increase was seen in a control group. When compared between the groups there was a duration-dependent maximum increase of 8-iso-PGF2alpha which was greatest in animals subjected to the longest period (VF12 min + CPR8 min) of no or low blood flow. In contrast, the greatest increase of 15-keto-dihydro-PGF2alpha was observed in the 13 min group (VF8 min + CPR5 min). Thus, a time-dependent cerebral oxidative injury occurs in conjunction which cardiac arrest and CPR.
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