| 1. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 2. |
- Liu, Yu, et al.
(författare)
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Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus
- 2023
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Ingår i: Journal of Inflammation Research. - : Dove Medical Press. - 1178-7031. ; 16, s. 5367-5383
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Methyltransferase like 1 (METTL1) regulates epitranscriptomes via the m7G modification in mammalian mRNA and microRNA. Systemic lupus erythematosus (SLE) is caused by abnormal immune reactivity and has diverse clinical manifestations. RNA methylation as a mechanism to regulate gene expression is widely implicated in immune regulation. However, the role of m7G in immune response of SLE has not been extensively studied.Patients and Methods: Expression of METTL1 was identified in the public dataset GSE122459 and validated in an independent cohort of SLE patients. We investigated the association between METTL1-expression and clinical manifestations of SLE. Subsequently, differentially expressed genes (DEG) that were correlated with METTL1-expression in GSE122459 were used for functional enrichment analysis. The correlation between infiltrating immune cells and METTL1, as well as candidate biomarkers identified to be correlated with either METTL1 or immune cell infiltration were assessed by single-sample GSEA. Potential mechanisms were explored with Gene ontology and KEGG pathway enrichment. Diagnostic performances of candidate biomarkers in SLE were analyzed.Results: The mRNA and protein expression of METTL1 in SLE patients were significantly decreased in both datasets. METTL1-coexpressed DEGs were enriched in several key immune-related pathways. Activated CD8 T cells, activated CD4 T cells, memory B cells and type 2 helper T cells were different between patients with high and low METTL1 expression. Further, activated CD8 T-cells, activated CD4 T-cells, memory B-cells were correlated with METTL1. The genes of LAMP3, CD83, PDCD1LG2, IGKVD3D-20, IGKV5-2, IGKV2D-30, IGLV3-19 and IGLV4-60 were identified as candidate targets that were correlated with immune cell proportion. Moreover, LAMP3, CD83, and PDCD1LG2 expression were of diagnostic value in SLE as indicated by ROC analysis.Conclusion: Our findings suggested that METTL1 and its candidate targets LAMP3, CD83, PDCD1LG2 may be used for diagnosing SLE and could be explored for developing targeted molecular therapy for SLE.
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| 3. |
- Dang, Junhua, et al.
(författare)
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The Beauty of the Zero : Replications and Extensions of the Hidden-Zero Effect in Delay Discounting Tasks
- 2021
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Ingår i: Social Psychology and Personality Science. - : SAGE Publications. - 1948-5506 .- 1948-5514. ; 12:4, s. 544-549
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Tidskriftsartikel (refereegranskat)abstract
- Unlike the presentation format in a typical delay discounting task (e.g., Would you prefer [A] US$4.3 today OR [B] US$7.5 in 22 days?), Magen et al. inserted a zero to each alternative (e.g., Would you prefer [A] US$4.3 today and US$0 in 22 days OR [B] US$0 today and US$7.5 in 22 days?) and found this manipulation effectively reduced delay discounting (d= .84), which was referred to as the hidden-zero effect. Study 1 was a direct replication of this effect. In Study 2, we tested whether the explicit-zero format could buffer against the detrimental effect of exposure to sexy cues on delay discounting. In Study 3, we explored the mechanism underlying the hidden-zero effect. Taken together, the hidden-zero effect was consistently found across all studies (N= 2,440) and our internal meta-analysis yielded a medium to large effect size (d= .52).
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| 4. |
- Dang, Junhua, et al.
(författare)
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The ego could be depleted, providing initial exertion is depleting : A preregistered experiment of the ego depletion effect
- 2017
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Ingår i: Social Psychology. - : Hogrefe Publishing Group. - 1864-9335 .- 2151-2590. ; 48:4, s. 242-245
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Tidskriftsartikel (refereegranskat)abstract
- The ego depletion effect has been examined by over 300 independent studies during the past two decades. Despite its pervasive influence, recently this effect has been severely challenged and asserted to be a fake. Based on an up-to-date meta-analysis that examined the effectiveness of each frequently used depleting task, we preregistered the current experiment with the aim to examine whether there would be an ego depletion effect when the Stroop task is used as the depleting task. The results demonstrated a significant ego depletion effect. The current research highlights the importance of the depleting task’s effectiveness. That is to say, the “ego” could be “depleted,” but only when initial exertion is “depleting.”
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| 5. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 6. |
- Cai, Xiaoping, et al.
(författare)
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Fabrication of Highly Porous CuAl Intermetallic by Thermal Explosion Using NaCl Space Holder
- 2018
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Ingår i: JOM. - : The Minerals, Metals, and Materials Society. - 1047-4838 .- 1543-1851. ; 70:10, s. 2173-2178
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Tidskriftsartikel (refereegranskat)abstract
- A high-porosity CuAl-based intermetallic compound with composition Cu-50 at.% Al has been successfully prepared by thermal explosion (TE) using NaCl as space holder. The results showed that the NaCl particles were completely removed from the green compact by water leaching. The temperature of the specimen during the TE and the evolution of the porous microstructure were investigated. The TE was ignited at 560°C, and the specimen temperature increased to 775°C in 3 s, resulting in formation of intermetallic CuAl and CuAl2 phases in the final product. A porous CuAl-based intermetallic compound with up to 62 vol.% open porosity was produced when adding 60 vol.% NaCl. The compound exhibited a bimodal pore size structure, including large pores (200 μm to 300 μm) that replicated the NaCl particles and small pores (5 μm to 10 μm) interspersed in the pore walls. Moreover, the large pores were interconnected by channels and formed an open CuAl-based intermetallic cellular structure, having great potential for use in heat exchange and filtration applications.
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| 7. |
- Cai, Xiaoping, et al.
(författare)
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Oxidation Resistance of Highly Porous Fe-Al Foams Prepared by Thermal Explosion
- 2018
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Ingår i: Metallurgical and Materials Transactions. A. - : Springer. - 1073-5623 .- 1543-1940. ; 49A:8, s. 3683-3691
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Tidskriftsartikel (refereegranskat)abstract
- Open-cell Fe-Al intermetallic foams were successfully prepared by a simple and energy-saving thermal explosion (TE) process. The effects of the Fe/Al molar ratio (Fe-(40–50) at. pct Al) and thermal treatment temperature on the TE temperature profile, phase composition, pore characteristics, and oxidation resistance of the prepared foams were investigated. The results showed that the Al content significantly influenced the ignition (Tig) and combustion (Tc) temperatures of the TE process; in particular, as the Al content decreased, Tig increased gradually from 623 °C to 636 °C and Tc decreased from 1059 °C to 981 °C. FeAl was identified as the dominant phase in the thermally treated foams. The Fe-Al intermetallic foams displayed an open porosity of 60 vol pct, with pores connected with each other to form an open pore structure. The formation of the pores was attributed to the expansion of interparticle pores in the pressed body during the TE reaction. X-ray photoelectron spectroscopy analysis of the Fe-50Al foam showed that the Al 2p and O 1s binding energies were 74.5 eV and at 531.4 eV, respectively. The formation of a surface alumina layer in the early stages of the oxidation process resulted in the parabolic oxidation rate law, and the Fe-50Al foams exhibited an excellent resistance to oxidation at 650 °C in air. These results suggest that the synthesized Fe-Al foams represent promising materials for applications involving an oxidizing environment and high temperatures.
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| 8. |
- He, Jia, et al.
(författare)
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A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease : the Systematic Investigation of Gastrointestinal Diseases in China
- 2010
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Ingår i: BMC Gastroenterology. - 1471-230X. ; 10, s. 94-
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Tidskriftsartikel (refereegranskat)abstract
- Background: The epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by the Montreal Definition. This study aimed to determine the prevalence of symptom-defined GERD across five regions of China, and to investigate variables associated with GERD. Methods: A representative sample of 18 000 adults (aged 18-80 years) were selected equally from rural and urban areas in each region (n = 1800). According to the Montreal Definition, GERD is present when mild symptoms of heartburn and/ or regurgitation occur on >= 2 days a week, or moderate-to-severe symptoms of heartburn and/or regurgitation occur on >= 1 day a week. Results: In total, 16 091 participants completed the survey (response rate: 89.4%) and 16 078 responses were suitable for analysis. Applying the Montreal criteria, the prevalence of symptom-defined GERD was 3.1% and varied significantly (p < 0.001) among the five regions (from 1.7% in Guangzhou to 5.1% in Wuhan) and between rural and urban populations (3.8% vs 2.4%). Factors significantly associated with GERD included living in a rural area and a family history of gastrointestinal diseases. Conclusions: This population-based survey found that the prevalence of symptom-defined GERD in China was 3.1%, which is lower than that found in Western countries.
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| 9. |
- Liu, Jinyang, et al.
(författare)
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Fabrication of Graphene Nanomesh and Improved Chemical Enhancement for Raman Spectroscopy
- 2012
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Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 116:29, s. 15741-15746
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Tidskriftsartikel (refereegranskat)abstract
- We propose a new approach to fabricate the graphene nanomesh through the local catalytic hydrogenation of carbon by Cu nanoparticles. It allows to tune the size and density of the holes in the nanomesh as well as the total edge length of the holes through the control of the thickness of the Cu film. The upshift of both G and 2D peaks in Raman spectra of the graphene nanomeshes indicates that the nanomesh is spontaneously p-type doped. Moreover, the split of G peak reveals that the doping is localized near the edge region of the hole in the nanomesh. Importantly, the nanomesh shows improved chemical enhancement for Raman spectra of absorbed RhB molecules as compared to the graphene. The edges in the nanomesh can enhance Raman spectroscopy via increasing both the local charge transfer and the ability to absorb RhB molecules. The results show that the graphene nanomesh has a great potential for the rapid and sensitive detection for the environmental monitoring and food security.
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| 10. |
- Liu, Yanan, et al.
(författare)
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A novel fabrication strategy for highly porous FeAl/Al2O3 composite by thermal explosion in vacuum
- 2018
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Ingår i: Vacuum. - : Elsevier. - 0042-207X. ; 149, s. 225-230
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Tidskriftsartikel (refereegranskat)abstract
- The high porosity of FeAl/Al2O3 composites was successfully prepared via a low-energy consumption method of thermal explosion (TE) in vacuum from reactant mixtures of Fe, Al and Fe2O3. The temperature profiles, phase compositions, microstructure, porosity and pore size of the products were investigated. The TE reactions were ignited between 639 and 648 °C and maximum combustion temperatures reached to 1196–1867 °C. XRD patterns showed that FeAl, Fe2Al5 and Al2O3 were formed via TE reaction, and FeAl and Al2O3 were evolved as dominant phase after the final sintering at 1100 °C. The FeAl/Al2O3 composites exhibited an interconnected pore structure with porosities and pore size of 52–61% and 27–32 μm, respectively.
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