| 1. |
- Zhang, Li, et al.
(författare)
-
Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31
- 2020
-
Ingår i: Applied Microbiology and Biotechnology. - : Springer Science and Business Media LLC. - 0175-7598 .- 1432-0614. ; 104:19, s. 8267-8278
-
Tidskriftsartikel (refereegranskat)abstract
- The current global demand for novel anti-TB drugs has drawn urgent attention on the discovery of natural product compounds with anti-TB activity. Lots of efforts have emphasized on environmental samples from unexplored or underexplored natural habits and identified numerous rare actinomycete taxa producing structurally diverse bioactive natural products. Herein, we report a survey of the rare actinobacteria diversity in Xinjiang region together with the discovery of anti-TB active natural products from these strains. We have collected 17 soil samples at different sites with different environmental conditions, from which 39 rare actinobacteria were identified by using a selective isolation strategy with 5 media variations. Among those isolated strains, XJ31 was identified as a new Nocardia sp. based on 16S rRNA gene analysis. Through one strain-many compounds (OSMAC) strategy combined with anti-Bacillus Calmette-Guérin bioassay-guided isolation, two groups of compounds were identified. They were twelve siderophores (nocardimicins, 1-12) and two anthraquinones (brasiliquinones, 13 and 14) and ten of them were identified as new compounds. The structures of the purified compounds were elucidated using HR-ESI-MS, 1D NMR, and 2D NMR techniques. The anti-TB bioassays revealed that the two benz[α]anthraquinones have potent activity against BCG (MICs = 25 μM), which can be used as a promising start point for further anti-TB drug development.
|
|
| 2. |
|
|
| 3. |
- Li, Ze, et al.
(författare)
-
Modulated-Virtual-Vector-Based Predictive Current Control for Dual Three-Phase PMSM With Enhanced Steady-State Performance
- 2023
-
Ingår i: IECON 2023 - 49th Annual Conference of the IEEE Industrial Electronics Society. - : Institute of Electrical and Electronics Engineers (IEEE).
-
Konferensbidrag (refereegranskat)abstract
- Dual three-phase permanent magnet synchronous machine (DTP-PMSM) has attracted great attention due to its high reliability and high-power output capacities. However, the conventional single-voltage-vector-based predictive current control (SV-PCC) for DTP-PMSM presents high torque ripple and current harmonics, and high computational burden. To solve those issues, a modulated-virtual-vector-based PCC (MVV-PCC) for DTP-PMSM is proposed in this paper. Wherein, twenty-four VVs are synthesized by the inherent voltage vectors, and two VVs and one zero voltage vector with optimal duty cycles are determined and applied in each sampling period to improve the steady-state performance. The selection of optimal VVs and the calculation of the optimal duty cycles are simplified by integrating the deadbeat control and modulation scheme. Various comparisons are carried out to validate the effectiveness and superiority of the proposed MVV-PCC strategy.
|
|
