| 1. |
- Liu, Yu, et al.
(författare)
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Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus
- 2023
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Ingår i: Journal of Inflammation Research. - : Dove Medical Press. - 1178-7031. ; 16, s. 5367-5383
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Methyltransferase like 1 (METTL1) regulates epitranscriptomes via the m7G modification in mammalian mRNA and microRNA. Systemic lupus erythematosus (SLE) is caused by abnormal immune reactivity and has diverse clinical manifestations. RNA methylation as a mechanism to regulate gene expression is widely implicated in immune regulation. However, the role of m7G in immune response of SLE has not been extensively studied.Patients and Methods: Expression of METTL1 was identified in the public dataset GSE122459 and validated in an independent cohort of SLE patients. We investigated the association between METTL1-expression and clinical manifestations of SLE. Subsequently, differentially expressed genes (DEG) that were correlated with METTL1-expression in GSE122459 were used for functional enrichment analysis. The correlation between infiltrating immune cells and METTL1, as well as candidate biomarkers identified to be correlated with either METTL1 or immune cell infiltration were assessed by single-sample GSEA. Potential mechanisms were explored with Gene ontology and KEGG pathway enrichment. Diagnostic performances of candidate biomarkers in SLE were analyzed.Results: The mRNA and protein expression of METTL1 in SLE patients were significantly decreased in both datasets. METTL1-coexpressed DEGs were enriched in several key immune-related pathways. Activated CD8 T cells, activated CD4 T cells, memory B cells and type 2 helper T cells were different between patients with high and low METTL1 expression. Further, activated CD8 T-cells, activated CD4 T-cells, memory B-cells were correlated with METTL1. The genes of LAMP3, CD83, PDCD1LG2, IGKVD3D-20, IGKV5-2, IGKV2D-30, IGLV3-19 and IGLV4-60 were identified as candidate targets that were correlated with immune cell proportion. Moreover, LAMP3, CD83, and PDCD1LG2 expression were of diagnostic value in SLE as indicated by ROC analysis.Conclusion: Our findings suggested that METTL1 and its candidate targets LAMP3, CD83, PDCD1LG2 may be used for diagnosing SLE and could be explored for developing targeted molecular therapy for SLE.
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| 2. |
- Sampson, Joshua N., et al.
(författare)
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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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| 3. |
- Liu, Junwei, et al.
(författare)
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Polymer synergy for efficient hole transport in solar cells and photodetectors
- 2023
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Ingår i: Energy & Environmental Science. - : ROYAL SOC CHEMISTRY. - 1754-5692 .- 1754-5706.
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Tidskriftsartikel (refereegranskat)abstract
- Hole transport materials (HTMs) have greatly advanced the progress of solution-based electronic devices in the past few years. Nevertheless, most devices employing dopant-free organic HTMs can only deliver inferior performance. In this work, we introduced a novel "polymer synergy" strategy to develop versatile dopant-free polymer HTMs for quantum dot/perovskite solar cells and photodetectors. With this synergy strategy, the optical, electrical and aggregation properties of polymer HTMs can be modulated, resulting in complementary absorption, high hole mobility, favorable energy landscape and moderate aggregation. Moreover, a clear orientational transition was observed for the developed HTMs with a 9-fold increase in the face-on/edge-on ratio, providing a highway-like carrier transport for electronic devices, as revealed by in situ characterization and ultrafast transient absorption. With these benefits, the photovoltaic and photodetection performance of quantum dot devices were boosted from 11.8% to 13.5% and from 2.95 x 10(12) to 3.41 x 10(13) Jones (over a 10-fold increase), respectively. Furthermore, the developed polymer HTMs can also significantly enhance the photovoltaic and photodetection performance of perovskite devices from 15.1% to 22.7% and from 2.7 x 10(12) to 2.17 x 10(13)Jones with the same device structure, indicating their great application potential in the emerging optoelectronics.
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| 4. |
- Ai, Songyuan, et al.
(författare)
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Ab Initio Calculations on Elastic Properties of IF Steel Matrix Phase at High Temperature Based on Lattice Expansion Theory
- 2020
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Ingår i: Metals. - : MDPI. - 2075-4701. ; 10:2
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Tidskriftsartikel (refereegranskat)abstract
- Elucidating the evolution law of the elastic properties of the matrix phase is of great significance for the control of steel properties and quality during continuous casting and subsequent heat treatment. In this paper, thermal expansion experiments and ab initio calculations are used to study the elastic properties of the interstitial free (IF) steel matrix phase in different magnetic states and crystal structures. The results show that the bulk modulus B and the tetragonal shear elastic constant C' for the entire temperature range decrease with increasing temperature, but C-44 is the opposite. While from paramagnetic (PM) to ferromagnetic (FM) state, C'(C-44) have changed similar to 188% (similar to 27%), B increases by similar to 55% during the crystal structure change (fcc -> bcc). With the FM to PM state, the Zener anisotropy parameter increases sharply, and Young's modulus decreases significantly in the [001] direction; the maximum difference is similar to 76 GPa. The evolution rate of average Young's modulus in single bcc-phase FM (fcc-phase PM) range reaches similar to 5.5(similar to 5.6) x 10(-2) GPa K-1. The research provides an effective method for ab initio calculation of the elastic properties of interstitial free and ultra-low carbon steels at high temperature, also furnishing a basis for the application of ab initio calculations to the high temperature performance of steel materials.
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| 5. |
- Ai, S., et al.
(författare)
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Ab Initio Study on Continuous Evolution of Mechanical Properties in Phase-Transition Region of Low-Carbon Steel
- 2020
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Ingår i: Steel Research International. - : Wiley-VCH Verlag. - 1611-3683 .- 1869-344X.
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Tidskriftsartikel (refereegranskat)abstract
- To control steel quality during continuous casting and subsequent heat treatment, an understanding of the evolution laws of mechanical properties during the austenite transition and the underlying mechanisms is of importance. Herein, the peak separation method is used to investigate the expansion behaviors in low-carbon steel. And the elastic properties of the matrix phase are calculated using the exact muffin-tin orbitals (EMTO) method. A continuous evolution model of high-temperature properties in the phase-transition region is established for ab initio data and experimental results. The evolution laws of the tetragonal shear elastic constant C′ and Young's modulus E agree well with that of the high-temperature strength. The critical temperature for ductility to brittleness is 850 °C. The matrix phase exhibits significantly brittleness character and increases slightly with decreasing temperature in single-phase paramagnetic (PM) γ-Fe region. The straightening zone temperature should be controlled above 950 °C to avoid cracks. In the austenite transition region, the drop rate of the magnetic moment reaches 18.90%. The findings suggest that the evolution law of mechanical properties of steels can be predicted from the elastic properties, especially during the austenite transition process, providing a basis for the prediction of material properties using ab initio methods.
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| 6. |
- Ai, S. -Y, et al.
(författare)
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High-temperature strength of l245mb slab and elastic properties of iron matrix
- 2019
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Ingår i: Kang T'ieh/Iron and Steel. - : Chinese Society for Metals. - 0449-749X. ; 54:8, s. 194-201
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Tidskriftsartikel (refereegranskat)abstract
- It‘s important to understand the evolution of high-temperature properties of slabs from the microscopic structure and the macroscopic structure, which is of great significance to the performance and quality control of slabs. The variation of the high-temperature strength of the L245MB slab with the temperature was measured by the hot tensile test technique with the Gleeble system. For the Fe matrix phase, which was under different crystal structures and magnetic states, the EMTO first-principles method was used to calculate the bulk modulus B, the single-crystal elastic constants c’ and c44, the polymorphic Young's modulus E, and the evolution of the system magnetic moment μ with temperature. The results showed that the cooling rate had little effect on the high-temperature strength evolution of the slab. The high-temperature strength took a transition near Ae3 and TC temperature, with a "platform" presented, where the average evolution rate of tensile strength was 0.008 Mpa/℃ and the yield strength was 0.076 Mpa/℃. The thermoplasticity of the slab had a different degree of decline in the temperature range of TC~Ae3, and the reduction of the area was the smallest at about 800℃, which was 59.02%~62.79%. The temperature range of ductility trough increased with the cooling rate increasing, and the surface temperature of the straightening zone should be controlled above 850 ℃ to avoid the crack generation. The elastic properties of the Fe matrix phase changed with the change of the magnetic state and the crystal structure. The transformation of the magnetic state had a greater influence on c’, c44, E, and the transformation of the crystal structure had a greater influence on B. During the transformation of FM to PM, c’ and E decreased by 64.09% and 10.33%, c44 increased by 57.82%, and B decreased by 34.38% with the change of bcc to fcc structure. The relationship between the evolution of single crystal elastic constant c’, polycrystalline Young's modulus E and the high-temperature strength of the slab were analyzed. It provides an idea for analyzing the macroscopic performance of the slab from the microstructural parameters of the crystal structure, which is a basis for the research and application of the first principles method in the high-temperature mechanical properties of steel materials.
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| 7. |
- D'Acunto, Giulio, et al.
(författare)
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Atomic Layer Deposition of Hafnium Oxide on InAs : Insight from Time-Resolved in Situ Studies
- 2020
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Ingår i: ACS Applied Electronic Materials. - : American Chemical Society (ACS). - 2637-6113. ; 2:12, s. 3915-3922
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Tidskriftsartikel (refereegranskat)abstract
- III-V semiconductors, such as InAs, with an ultrathin high-κ oxide layer have attracted a lot of interests in recent years as potential next-generation metal-oxide-semiconductor field-effect transistors, with increased speed and reduced power consumption. The deposition of the high-κ oxides is nowadays based on atomic layer deposition (ALD), which guarantees atomic precision and control over the dimensions. However, the chemistry and the reaction mechanism involved are still partially unknown. This study reports a detailed time-resolved analysis of the ALD of high-κ hafnium oxide (HfOx) on InAs(100). We use ambient pressure X-ray photoemission spectroscopy and monitor the surface chemistry during the first ALD half-cycle, i.e., during the deposition of the metalorganic precursor. The removal of In and As native oxides, the adsorption of the Hf-containing precursor molecule, and the formation of HfOx are investigated simultaneously and quantitatively. In particular, we find that the generally used ligand exchange model has to be extended to a two-step model to properly describe the first half-cycle in ALD, which is crucial for the whole process. The observed reactions lead to a complete removal of the native oxide and the formation of a full monolayer of HfOx already during the first ALD half-cycle, with an interface consisting of In-O bonds. We demonstrate that a sufficiently long duration of the first half-cycle is essential for obtaining a high-quality InAs/HfO2 interface.
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| 8. |
- Han, Xinlu, et al.
(författare)
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A projection procedure to obtain adiabatic flames from non-adiabatic flames using heat flux method
- 2021
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Ingår i: Proceedings of the Combustion Institute. - : Elsevier BV. - 1540-7489. ; 38:2, s. 2143-2151
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Tidskriftsartikel (refereegranskat)abstract
- Laminar burning velocity S L at elevated temperature T u and its temperature dependence coefficient α in SL/S0L = (Tu T0u)α are important parameters for industrial applications. However, experimental systems with high unburned gas temperatures may encounter pre-dissociation, leading to significant data scattering in the measurements. To negate this, the present work proposes a projection procedure to obtain adiabatic flame parameters at various unburned gas temperatures using non-adiabatic flames on a heat flux burner, by which the preheating can be achieved within much shorter time scale than, e.g., in conventional spherical flame methods, and the advantage of good data consistency in the heat flux method is kept. Burning velocity experiments were carried out with CH 4 + air atmospheric flames covering T u = 298-473 K, and the results show good agreement with the proposed projection equations. OH * spontaneous emission profiles were measured, indicating that the projection may extend to other flame characteristics. Uncertainty of the projection process was evaluated and comparisons were made with six popular kinetic mechanisms: GRI-Mech, FFCM-1 mech, Konnov mechanism, Glarborg mechanism, San Diego mechanism and Aramco mechanism. It is found that the simulated coefficients α are higher than experimental data especially at rich conditions; this is also found for literature values of high unburned gas temperature experiments. Possible reasons for this divergence are discussed.
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| 9. |
- Han, Xinlu, et al.
(författare)
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Temperature dependence of the laminar burning velocity for n-heptane and iso-octane/air flames
- 2020
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Ingår i: Fuel. - : Elsevier BV. - 0016-2361. ; 276
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Tidskriftsartikel (refereegranskat)abstract
- The heat flux method is advantageous for obtaining adiabatic stretch-less flame and measuring laminar burning velocity, SL, with low uncertainty. However, its implementation is sometimes hampered by the instability, manifested as cellularity of the flame stabilized over a flat perforated burner. This paper summarizes the approaches of flame cellularity abatement on the heat flux burner, which are implemented in the present study for measuring burning velocities of n-heptane and iso-octane/air flames. The combination of approaches helped to effectively overcome the cellularity at the fuel-rich side of the tested flames, and the SL was measured at unburnt temperatures Tu=298K-358K and equivalence ratios ϕ=0.7-1.6, at atmospheric pressure, with the SL uncertainty being evaluated. Numerical simulations were carried out using LLNL mechanism, Chaos mechanism and Luong171 mechanism, and the results agree well with the experimental data. From the obtained experimental and numerical SL data, the temperature coefficients α in [Formula presented] as well as the overall activation energy, Ea, were derived. It was noted that for n-heptane and iso-octane/air flames, the tendencies of the α and Ea against ϕ resemble those for methane, ethane, and propane/air flames. Distinct over-rich flame structures were observed and discussed for n-heptane and iso-octane/air flames around ϕ≥1.5. Moreover, extrapolation proced/ure of the SLmeasurements was validated using analytical presentation of the heat flux method sensitivity, s vs. [Formula presented], and other parameters involved in the data processing, which may help to improve the accuracy of future experiments.
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| 10. |
- Han, Xinlu, et al.
(författare)
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The temperature dependence of the laminar burning velocity and superadiabatic flame temperature phenomenon for NH3/air flames
- 2020
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Ingår i: Combustion and Flame. - : Elsevier BV. - 0010-2180. ; 217, s. 314-320
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Tidskriftsartikel (refereegranskat)abstract
- Combustion of ammonia (NH3) as a carbon-free alternative fuel has been recently widely studied, with vast majority of the burning velocity data obtained at room temperature. In the present study, the laminar burning velocity SL of NH3/air mixtures has been measured at unburnt gas temperature Tu from 298 K to 448 K, covering equivalence ratios from 0.85 to 1.25 and at 1 atm using the heat flux method. Kinetic simulations were made with five literature mechanisms developed for NH3 combustion, i.e., Nakamura et al., Otomo et al., San Diego, Okafor et al., and Mei et al. mechanisms, and the influence of radiation heat losses was considered. Using the obtained burning velocity data at different temperatures, the temperature dependence coefficients α in [Formula presented] were derived, and compared with different models’ predictions. Further analyses of the temperature dependence of SL were carried out through examination of the overall activation energy, temperature and species profiles as well as the reaction paths, and a unique flame structure at the rich side of adiabatic NH3/air flames was found, which resembles ‘over-rich’ phenomena in hydrocarbon flames. At equivalence ratio larger than 1.1 ± 0.05, the NH3/air flames become so rich that (1) the NH2 radical overwhelms the H and OH radicals in maximum mole fraction; (2) after the flame front, H2O converts back to H2 with NO formed at the same time, causing the superadiabatic flame temperature phenomena, i.e. adiabatic flame temperature being lower than the maximum achieved in the flame. Moreover, local minimum NO concentration is found right after the over-rich NH3/air flame front, which may be helpful in reducing NO emissions from NH3 flames in practical applications.
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