| 1. |
- Danelid, Hans, et al.
(författare)
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Kartläggning av högskolans elektroniska publicering och rekommendationer för nationell samverkan : Återrapportering till SUHF:s Forum för bibliotekschefer
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Resultatet av arbetsgruppens genomförda kartläggning av e-publicering visar att den stora utmaningen för de flesta av SUHF:s medlemmar som idag driver system för e-publicering är att marknadsföra och förankra detta arbete. Det finns svårigheter att nå ut till anställda på det sätt som krävs för att få igång fungerande arbetsflöden och ökad digital publicering. Därför är det nu viktigt att fortsätta utvecklingen med att skapa en bredare förankring vid universitet och högskolor. Kartläggningen visar vidare att intresset för nationell samordning av elektro-nisk publicering är stort hos de lokalt ansvariga för publiceringsfrågor. Här har SUHF en vik-tig funktion att fylla för att bistå med förankring och samordning.Arbetsgruppen för Högskolans elektroniska publicering rekommenderar följande fortsatta åtgärder för nationell samverkan via SUHF/Forum för bibliotekschefer:• SUHF tar ansvar för en permanent övergripande och nationell samverkan kring hög-skolans elektroniska publicering.• SUHF formulerar riktlinjer till lärosätenas ledningar för hur elektronisk publicering, publiceringsredovisning och Open Access kan införlivas i lärosätenas verksamhet.• SUHF bör försöka hitta gemensamma finansieringsformer för funktioner där samord-ning är angelägen.
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| 2. |
- Möller, Jette, et al.
(författare)
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Widowhood and the risk of psychiatric care, psychotropic medication and all-cause mortality : a cohort study of 658 022 elderly people in Sweden
- 2011
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Ingår i: Aging & Mental Health. - : Informa UK Limited. - 1360-7863 .- 1364-6915. ; 15:2, s. 259-266
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To study the effect of widowhood on the risk of psychiatric care, psychotropic medication and mortality, and to study if the effect is modified by educational level. Method: A nationwide, register-based cohort study. All married or widowed individuals aged 75 and older who were alive and registered in Sweden on 31 December 2004 and still registered on 31 December 2005. A total of 658,022 individuals were included in the study and followed in 2006. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated. Results: Loss of spouse increased the risk of outpatient psychiatric visits, psychotropic medication and all-cause mortality. Prescribed psychotropic medication was more common among those newly bereaved, adjusted OR of 1.46 (95% CI 1.41-1.50), compared to those married. For those widowed for a longer period, the corresponding estimate was 1.12 (95% CI 1.11-1.14). The OR for all-cause mortality was 1.18 (95% CI 1.11-1.26). The analyses also indicated different effects on inpatient care depending on educational level. Conclusion: Loss of spouse increases the risk of people getting psychiatric care, both for severe and minor psychiatric conditions. The effect seems to differ depending on educational level. Further studies are needed to disentangle the mechanism behind the effects of each measurement of psychiatric conditions and how these are affected by educational level.
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| 3. |
- Pacurar, Daniel Ioan, et al.
(författare)
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Identification of new adventitious rooting mutants amongst suppressors of the Arabidopsis thaliana superroot2 mutation
- 2014
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Ingår i: Journal of Experimental Botany. - : Oxford University Press. - 0022-0957 .- 1460-2431. ; 65:6, s. 1605-1618
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Tidskriftsartikel (refereegranskat)abstract
- The plant hormone auxin plays a central role in adventitious rooting and is routinely used with many economically important, vegetatively propagated plant species to promote adventitious root initiation and development on cuttings. Nevertheless the molecular mechanisms through which it acts are only starting to emerge. The Arabidopsis superroot2-1 (sur2-1) mutant overproduces auxin and, as a consequence, develops excessive adventitious roots in the hypocotyl. In order to increase the knowledge of adventitious rooting and of auxin signalling pathways and crosstalk, this study performed a screen for suppressors of superroot2-1 phenotype. These suppressors provide a new resource for discovery of genetic players involved in auxin signalling pathways or at the crosstalk of auxin and other hormones or environmental signals. This study reports the identification and characterization of 26 sur2-1 suppressor mutants, several of which were identified as mutations in candidate genes involved in either auxin biosynthesis or signalling. In addition to confirming the role of auxin as a central regulator of adventitious rooting, superroot2 suppressors indicated possible crosstalk with ethylene signalling in this process.
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| 4. |
- Rabe, Hardis, et al.
(författare)
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Neonatal gut colonization by Bifidobacterium is associated with higher childhood cytokine responses.
- 2020
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Ingår i: Gut microbes. - : Informa UK Limited. - 1949-0984 .- 1949-0976. ; 12:1, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- The gut microbiota is a major stimulus for the immune system, and late acquisition of bacteria and/or reduced complexity of the gut flora may delay adaptive immune maturation. However, it is unknown how the gut bacterial colonization pattern in human infants is related to T cell activation during early childhood. We followed 65 Swedish children in the FARMFLORA cohort, from birth up to 3years of age. In fecal samples collected at several time points during the first year of life, the gut colonization pattern was investigated with the use of both 16S rRNA next generation sequencing (NGS) and culture-based techniques. This was related to production of IL-13, IL-5, IL-6, TNF, IL-1β and IFN-γ by PHA-stimulated fresh mononuclear cells and to proportions of CD4+ T cells that expressed CD45RO at 36months of age. Both NGS and culture-based techniques showed that colonization by Bifidobacterium at 1week of age associated with higher production of IL-5, IL-6, IL-13, TNF and IL-1β at 36months of age. By contrast, gut colonization by Enterococcus, Staphylococcus aureus or Clostridium in early infancy related inversely to induced IL-13, IL-5 and TNF at 3years of age. Infants with elder siblings produced more cytokines and had a larger fraction of CD45RO+ T cells compared to single children. However, controlling for these factors did not abolish the effect of colonization by Bifidobacterium on immune maturation. Thus, gut colonization in early infancy affects T cell maturation and Bifidobacterium may be especially prone to induce infantile immune maturation.
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