| 1. |
- Lindow, Thomas, et al.
(författare)
-
Erroneous computer-based interpretations of atrial fibrillation and atrial flutter in a Swedish primary health care setting
- 2019
-
Ingår i: Scandinavian Journal of Primary Health Care. - : Taylor & Francis Group. - 0281-3432 .- 1502-7724. ; 37:4, s. 426-433
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To describe the incidence of incorrect computerized ECG interpretations of atrial fibrillation or atrial flutter in a Swedish primary care population, the rate of correction of computer misinterpretations, and the consequences of misdiagnosis. Design: Retrospective expert re-analysis of ECGs with a computer-suggested diagnosis of atrial fibrillation or atrial flutter. Setting: Primary health care in Region Kronoberg, Sweden. Subjects: All adult patients who had an ECG recorded between January 2016 and June 2016 with a computer statement including the words 'atrial fibrillation' or 'atrial flutter'. Main outcome measures: Number of incorrect computer interpretations of atrial fibrillation or atrial flutter; rate of correction by the interpreting primary care physician; consequences of misdiagnosis of atrial fibrillation or atrial flutter. Results: Among 988 ECGs with a computer diagnosis of atrial fibrillation or atrial flutter, 89 (9.0%) were incorrect, among which 36 were not corrected by the interpreting physician. In 12 cases, misdiagnosed atrial fibrillation/flutter led to inappropriate treatment with anticoagulant therapy. A larger proportion of atrial flutters, 27 out of 80 (34%), than atrial fibrillations, 62 out of 908 (7%), were incorrectly diagnosed by the computer. Conclusions: Among ECGs with a computer-based diagnosis of atrial fibrillation or atrial flutter, the diagnosis was incorrect in almost 10%. In almost half of the cases, the misdiagnosis was not corrected by the overreading primary-care physician. Twelve patients received inappropriate anticoagulant treatment as a result of misdiagnosis.
|
|
| 2. |
- Lindow, Thomas, et al.
(författare)
-
Pheochromocytoma – An ECG diagnosis?
- 2020
-
Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736. ; 58, s. 7-9
-
Tidskriftsartikel (refereegranskat)abstract
- Pheochromocytoma is a rare catecholamine-secreting tumor in the adrenal medulla. In some cases, the first symptoms are cardiovascular. We report on two patients with pheochromocytoma, who both presented with bidirectional ventricular tachycardia (BDVT). We elaborate on the mechanisms of BDVT in the setting of pheochromocytoma.
|
|
| 3. |
- Ljungström, Olle, et al.
(författare)
-
Glucagon-induced phosphorylation of pyruvate kinase (type L) in rat liver slices
- 1977
-
Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 78:4, s. 1147-1155
-
Tidskriftsartikel (refereegranskat)abstract
- The effect of glucagon on the phosphorylation of pyruvate kinase in 32P-labelled slices from rat liver was investigated. Pyruvate kinase was isolated by immunoadsorbent chromatography. The enzyme was partially phosphorylated in the absence of added hormone (0.2 mol of phosphate/mol of enzyme subunit). Upon incubation with 10−7 M glucagon, the incorporation of [32P]phosphate was 0.6–0.7 mol/mol of enzyme subunit. Concomitantly, the concentration of intracellular cyclic 3′,5′-AMP increased from 0.3 to 3.2 μM. The phosphorylation inhibited the enzyme activity at low concentrations of phosphoenolpyruvate (60% at 0.5 mM). Almost maximal phosphorylation of the enzyme was reached within 2 min after the addition of glucagon. The concentration of hormone giving half maximal effect on the pyruvate kinase phosphorylation was about 7×10−9M. The inactivation of the enzyme paralleled the increase in phosphorylation. It is concluded that pyruvate kinase is phosphorylated in the intact liver cell.
|
|
| 4. |
|
|
| 5. |
|
|
