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Sökning: WFRF:(Loeffler Maarten)

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1.
  • Burke, Kyle, et al. (författare)
  • Single-Player and Two-Player Buttons & Scissors Games
  • 2016
  • Ingår i: DISCRETE AND COMPUTATIONAL GEOMETRY AND GRAPHS, JCDCGG 2015. - Cham : SPRINGER INT PUBLISHING AG. - 9783319485324 - 9783319485317 ; , s. 60-72
  • Konferensbidrag (refereegranskat)abstract
    • We study the computational complexity of the Buttons amp; Scissors game and obtain sharp thresholds with respect to several parameters. Specifically we show that the game is NP-complete for C = 2 colors but polytime solvable for C = 1. Similarly the game is NP-complete if every color is used by at most F = 4 buttons but polytime solvable for F amp;lt;= 3. We also consider restrictions on the board size, cut directions, and cut sizes. Finally, we introduce several natural two-player versions of the game and show that they are PSPACE-complete.
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2.
  • Dai, Qile, et al. (författare)
  • OTTERS: a powerful TWAS framework leveraging summary-level reference data
  • 2023
  • Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies.
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