SwePub - sökning: WFRF:(Loughlin A. Jane)

Numrering	Referens	Omslagsbild	Hitta
1.	East, Emma, et al. (författare) A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury 2013 Ingår i: Regenerative Medicine. - : Future Medicine Ltd.. - 1746-0751 .- 1746-076X. ; 8:6, s. 739-746 Tidskriftsartikel (refereegranskat)abstract AIM: This study aimed to develop a 3D culture model to test the extent to which transplanted stem cells modulate astrocyte reactivity, where exacerbated glial cell activation could be detrimental to CNS repair success.MATERIALS & METHODS: The reactivity of rat astrocytes to bone marrow mesenchymal stem cells, neural crest stem cells (NCSCs) and differentiated adipose-derived stem cells was assessed after 5 days. Schwann cells were used as a positive control.RESULTS: NCSCs and differentiated Schwann cell-like adipose-derived stem cells did not increase astrocyte reactivity. Highly reactive responses to bone marrow mesenchymal stem cells and Schwann cells were equivalent.CONCLUSION: This approach can screen therapeutic cells prior to in vivo testing, allowing cells likely to trigger a substantial astrocyte response to be identified at an early stage. NCSCs and differentiated Schwann cell-like adipose-derived stem cells may be useful in treating CNS damage without increasing astrogliosis.

East, Emma, et al. (författare)
A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury
2013
Ingår i: Regenerative Medicine. - : Future Medicine Ltd.. - 1746-0751 .- 1746-076X. ; 8:6, s. 739-746
Tidskriftsartikel (refereegranskat)abstract
- AIM: This study aimed to develop a 3D culture model to test the extent to which transplanted stem cells modulate astrocyte reactivity, where exacerbated glial cell activation could be detrimental to CNS repair success.MATERIALS & METHODS: The reactivity of rat astrocytes to bone marrow mesenchymal stem cells, neural crest stem cells (NCSCs) and differentiated adipose-derived stem cells was assessed after 5 days. Schwann cells were used as a positive control.RESULTS: NCSCs and differentiated Schwann cell-like adipose-derived stem cells did not increase astrocyte reactivity. Highly reactive responses to bone marrow mesenchymal stem cells and Schwann cells were equivalent.CONCLUSION: This approach can screen therapeutic cells prior to in vivo testing, allowing cells likely to trigger a substantial astrocyte response to be identified at an early stage. NCSCs and differentiated Schwann cell-like adipose-derived stem cells may be useful in treating CNS damage without increasing astrogliosis.

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