| 1. |
- Makafe, Gaelle G., et al.
(författare)
-
Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
- 2019
-
Ingår i: Cell Chemical Biology. - : CELL PRESS. - 2451-9456 .- 2451-9448. ; 26:8, s. 1187-
-
Tidskriftsartikel (refereegranskat)abstract
- There is a great need for identification and development of new anti-tuberculosis drugs with novel targets. Recent drug-discovery efforts typically focus on identifying inhibitors but not activators that perturb metabolic enzymes' functions as a means to kill Mycobacterium tuberculosis (Mtb). Here, we describe a class of quinoline compounds, Z0933/Z0930, which kill Mtb by acting as activators of glutamate kinase (GK), a previously untargeted enzyme catalyzing the first step of proline biosynthesis. We further show that Z0933/Z0930 augment proline production and induce Mtb killing via proline-derived redox imbalance and production of reactive oxygen species. This work highlights the effectiveness of gain-of-function probes against Mtb and provides a framework for the discovery of next-generation allosteric activators of GK.
|
|
| 2. |
- Zhang, Yong, 1982, et al.
(författare)
-
Improved Thermal Properties of Three-Dimensional Graphene Network Filled Polymer Composites
- 2022
-
Ingår i: Journal of Electronic Materials. - : Springer Science and Business Media LLC. - 1543-186X .- 0361-5235. ; 51:1, s. 420-425
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents the improved thermal property of three-dimensional (3D) graphene network modified polydimethylsiloxane (PDMS) composites. It shows that with a 2 wt.% loading of graphene foams (GF), the thermal conductivity of GF/PDMS composite was successfully increased from 0.19 W/mK to 0.42 W/mK, which is 2.2 times higher than that of neat PDMS. However, if GF was transformed into graphene sheets (GS) by sonication, the thermal conductivity of GS/PDMS was decreased to 0.28 W/mK. The remarkable improvement of the thermal properties is attributed to the 3D interconnected graphene network in GF, which form continuous heat transfer networks. Furthermore, the finite element analysis was conducted to evaluate the effect of GFs in composites, where some parameters such as thickness and thermal conductivity were analyzed and discussed. Our results indicate that the continuous 3D GFs holds great potential as fillers to improve the thermal property of polymer materials.
|
|
