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- Grinnemo, Karl-Johan, 1968-
(författare)
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Transport Services for Soft Real-Time Applications in IP Networks
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In recent years, Internet and IP technologies have made inroads into almost every communication market ranging from best-effort services such as email and Web, to soft real-time applications such as VoIP, IPTV, and video. However, providing a transport service over IP that meets the timeliness and availability requirements of soft real-time applications has turned out to be a complex task. Although network solutions such as IntServ, DiffServ, MPLS, and VRRP have been suggested, these solutions many times fail to provide a transport service for soft real-time applications end to end. Additionally, they have so far only been modestly deployed. In light of this, this thesis considers transport protocols for soft real-time applications. Part I of the thesis focuses on the design and analysis of transport protocols for soft real-time multimedia applications with lax deadlines such as image-intensive Web applications. Many of these applications do not need a completely reliable transport service, and to this end Part I studies so-called partially reliable transport protocols, i.e., transport protocols that enable applications to explicitly trade reliability for improved timeliness. Specifically, Part I investigates the feasibility of designing retransmission-based, partially reliable transport protocols that are congestion aware and fair to competing traffic. Two transport protocols are presented in Part I, PRTP and PRTP-ECN, which are both extensions to TCP for partial reliability. Simulations and theoretical analysis suggest that these transport protocols could give a substantial improvement in throughput and jitter as compared to TCP. Additionally, the simulations indicate that PRTP-ECN is TCP friendly and fair against competing congestion-aware traffic such as TCP flows. Part I also presents a taxonomy for retransmission-based, partially reliable transport protocols. Part II of the thesis considers the Stream Control Transmission Protocol (SCTP), which was developed by the IETF to transfer telephony signaling traffic over IP. The main focus of Part II is on evaluating the SCTP failover mechanism. Through extensive experiments, it is suggested that in order to meet the availability requirements of telephony signaling, SCTP has to be configured much more aggressively than is currently recommended by IETF. Furthermore, ways to improve the transport service provided by SCTP, especially with regards to the failover mechanism, are suggested. Part II also studies the effects of Head-of-Line Blocking (HoLB) on SCTP transmission delays. HoLB occurs when packets in one flow block packets in another, independent, flow. The study suggests that the short-term effects of HoLB could be substantial, but that the long-term effects are marginal.
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- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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- Landström, Sara, et al.
(författare)
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TCP-Aix : making TCP robust to reordering and delay variations
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, we describe and evaluate TCP-Aix, a sender-side TCP algorithm designed to make TCP performance robust to packet reordering and delay. TCP-Aix consists of three novel components: (i) decoupling of loss recovery actions from congestion control actions, (ii) candid growth of the congestion window upon reception of dupacks, allowing for improved performance in reordering environments, and (iii) an algorithm for determining an appropriate dupthresh value. The results from our simulation study show that, by combining these three components, the performance of TCP-Aix is largely impervious even to the highest packet reordering rates investigated in this paper of 8\%, where the duration of the reordering is in the order 2-3 end-to-end RTTs. TCP-Aix outperforms a simulated state-of-the-art TCP sender as well as a TCP-NCR sender, the performance of which both display a much stronger dependence on packet reordering. Improved performance in the presence of delay spikes is also shown. Strengthened by simulation results, we further argue that the improved performance of TCP-Aix does not come at the expense of other, competing, TCP senders. Rather, the TCP-Aix senders utilise bandwidth that would otherwise have been left unutilised. We therefore believe that a gradual deployment of TCP-Aix would be feasible.
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- Rydén, Lars, et al.
(författare)
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ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
- 2013
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:39, s. 3035-3087
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Tidskriftsartikel (refereegranskat)abstract
- This is the second iteration of the European Society of Cardiology (ESC) and European Association for the Study of Diabetes (EASD) joining forces to write guidelines on the management of diabetes mellitus (DM), pre-diabetes, and cardiovascular disease (CVD), designed to assist clinicians and other healthcare workers to make evidence-based management decisions. The growing awareness of the strong biological relationship between DM and CVD rightly prompted these two large organizations to collaborate to generate guidelines relevant to their joint interests, the first of which were published in 2007. Some assert that too many guidelines are being produced but, in this burgeoning field, five years in the development of both basic and clinical science is a long time and major trials have reported in this period, making it necessary to update the previous Guidelines.
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