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- 2019
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Tidskriftsartikel (refereegranskat)
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- Apicella, Coren L, et al.
(författare)
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Assortative Human Pair-Bonding for Partner Ancestry and Allelic Variation of the Dopamine Receptor D4 (DRD4) Gene
- 2010
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Ingår i: Social Cognitive and Affective Neuroscience. - : Oxford University Press (OUP): Policy C - Option D. - 1749-5024 .- 1749-5016. ; 5:2-3, s. 194-202
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Tidskriftsartikel (refereegranskat)abstract
- The 7 repeat (7R) allele of the dopamine receptor D4 gene has been associated with attention deficit hyperactivity disorder and risk taking. On the cross-population scale, 7R allele frequencies have been shown to be higher in populations with more of a history of long-term migrations. It has also been shown that the 7R allele is associated with individuals having multiple ancestries. Here, we conduct a replication of this latter finding with two independent samples. Measures of subjects' ancestry are used to examine past reproductive bonds. The individuals' history of interracial/ancestral dating and their feelings about this are also assessed. Tentative support for an association between multiple ancestries and the 7R allele was found. These results are dependent upon the method of questioning subjects about their ancestries, with only finer-scale measures of ancestry being associated with 7R. Interracial dating and feelings about interracial pairing were not related to the presence of the 7R allele. This study provides continued support for a role for the 7R allele in migration and/or mate choice patterns. However, replications and extensions of this study are needed and the way ancestry/race is assessed must be carefully considered.
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- Campbell, Benjamin, et al.
(författare)
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The 7R polymorphism in the dopamine receptor D(4) gene (DRD4) is associated with financial risk taking in men
- 2009
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Ingår i: Evolution and Human Behavior. - : Elsevier. - 1090-5138. ; 30:2, s. 85-92
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Tidskriftsartikel (refereegranskat)abstract
- Individuals exhibit substantial heterogeneity in financial risk aversion. Recent work on twins demonstrated that some variation is influenced by individual heritable differences. Despite this, there has been no study investigating possible genetic loci associated with financial risk taking in healthy individuals. Here, we examined whether there is an association between financial risk preferences, elicited experimentally in a game with real monetary payoffs, and the presence of the 7-repeat allele (7R+) in the dopamine receptor D(4) gene as well as the presence of the Al allele (Al+) in the dopamine receptor D(2) gene in 94 young men. Although we found no association between the Al allele and risk preferences, we did find that 7R+ men are significantly more risk loving than 7R- men. This polymorphism accounts for roughly 20% of the heritable variation in financial risk taking. We suggest that selection for the 7R allele may be for a behavioral phenotype associated with risk taking. This is consistent with previous evolutionary explanations suggesting that selection for this allele was for behaviors associated with migration and male competition, both of which entail an element of risk. (C) 2009 Elsevier Inc. All rights reserved.
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| 6. |
- Dreber Almenberg, Anna, et al.
(författare)
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Ancestry and allelic variation of the dopamine receptor D4 (DRD4) gene
- 2010
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Ingår i: Social Cognitive and Affective Neuroscience. - : Oxford University Press. - 1749-5016 .- 1749-5024. ; 5:2-3, s. 194-202
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Tidskriftsartikel (refereegranskat)abstract
- The 7 repeat (7R) allele of the dopamine receptor D4 gene has been associated with attention deficit hyperactivity disorder and risk taking. On the cross-population scale, 7R allele frequencies have been shown to be higher in populations with more of a history of long-term migrations. It has also been shown that the 7R allele is associated with individuals having multiple ancestries. Here, we conduct a replication of this latter finding with two independent samples. Measures of subjects’ ancestry are used to examine past reproductive bonds. The individuals’ history of interracial/ancestral dating and their feelings about this are also assessed. Tentative support for an association between multiple ancestries and the 7R allele was found. These results are dependent upon the method of questioning subjects about their ancestries, with only finer-scale measures of ancestry being associated with 7R. Interracial dating and feelings about interracial pairing were not related to the presence of the 7R allele. This study provides continued support for a role for the 7R allele in migration and/or mate choice patterns. However, replications and extensions of this study are needed and the way ancestry/race is assessed must be carefully considered.
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| 9. |
- Dreber Almenberg, Anna, et al.
(författare)
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The Dopamine Receptor D4 Gene (DRD4) and Self-Reported Risk Taking in the Economic Domain
- 2011
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Recent evidence suggests that individual variation in risk taking is partly due to genetic factors. Methodology/Principal Findings: We explore how self-reported risk taking in different domains correlates with variation in the dopamine receptor D4 gene (DRD4). Past studies conflict on the influence of DRD4 in relation to risk taking. A sample of 237 serious tournament contract bridge players, experts on risk taking in one domain, was genotyped for having a 7-repeat allele (7R+) or not (7R-) at DRD4. No difference was found between 7R+ and 7R- individuals in general risk taking or in several other risk-related activities. Conclusion: In this sample of individuals (tournament bridge players) there is no relationship between DRD4 genotype and self-reported risk taking in different domains.
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