| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Burnum-Johnson, Kristin E., et al.
(författare)
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New Views of Old Proteins : Clarifying the Enigmatic Proteome
- 2022
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Ingår i: Molecular & Cellular Proteomics. - : Elsevier BV. - 1535-9476 .- 1535-9484. ; 21:7
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Tidskriftsartikel (refereegranskat)abstract
- All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.
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| 3. |
- Danielsson, Frida, 1984-
(författare)
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Integration of RNA and protein expression profiles to study human cells
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cellular life is highly complex. In order to expand our understanding of the workings of human cells, in particular in the context of health and disease, detailed knowledge about the underlying molecular systems is needed. The unifying theme of this thesis concerns the use of data derived from sequencing of RNA, both within the field of transcriptomics itself and as a guide for further studies at the level of protein expression. In paper I, we showed that publicly available RNA-seq datasets are consistent across different studies, requiring only light processing for the data to cluster according to biological, rather than technical characteristics. This suggests that RNA-seq has developed into a reliable and highly reproducible technology, and that the increasing amount of publicly available RNA-seq data constitutes a valuable resource for meta-analyses. In paper II, we explored the ability to extrapolate protein concentrations by the use of RNA expression levels. We showed that mRNA and corresponding steady-state protein concentrations correlate well by introducing a gene-specific RNA-to-protein conversion factor that is stable across various cell types and tissues. The results from this study indicate the utility of RNA-seq also within the field of proteomics.The second part of the thesis starts with a paper in which we used transcriptomics to guide subsequent protein studies of the molecular mechanisms underlying malignant transformation. In paper III, we applied a transcriptomics approach to a cell model for defined steps of malignant transformation, and identified several genes with interesting expression patterns whose corresponding proteins were further analyzed with subcellular spatial resolution. Several of these proteins were further studied in clinical tumor samples, confirming that this cell model provides a relevant system for studying cancer mechanisms. In paper IV, we continued to explore the transcriptional landscape in the same cell model under moderate hypoxic conditions.To conclude, this thesis demonstrates the usefulness of RNA-seq data, from a transcriptomics perspective and beyond; to guide in analyses of protein expression, with the ultimate goal to unravel the complexity of the human cell, from a holistic point of view.
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| 4. |
- Deans, Andrew R, et al.
(författare)
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Finding Our Way through Phenotypes.
- 2015
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Ingår i: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
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| 5. |
- Delcey, Mickael G, 1988-, et al.
(författare)
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Soft X-ray signatures of cationic manganese–oxo systems, including a high-spin manganese(v) complex
- 2022
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Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 24:6, s. 3598-3610
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Tidskriftsartikel (refereegranskat)abstract
- Limitations in synthesis of high-valent metal–oxo complexes are circumvented by trapping a series of ionic Mn–oxo complexes. One of them is a rare high-spin Mn(v)–oxo, which can serve as a template to identify similar intermediates in catalysis.
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| 6. |
- Eskilsson, Lena, et al.
(författare)
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Film Tourism collaborations: a critical analysis of INTERREG destination development projects
- 2018
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Ingår i: The Routledge Handbook on Popular Culture and Tourism. - 9781138678354 - 9781315559018
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Bokkapitel (refereegranskat)abstract
- This chapter discusses the different stakeholders that take part in film tourism development projects, how do they collaborate, and what is actually possible to achieve? It is a critical analysis especially when it comes to the selection of stakeholders, the project process and potential outcomes in EU-funded INTERREG projects. The analysis contributes to enhance the knowledge about the different stakeholders involved. It is evident that a new stakeholder has emerged in film tourism development projects; film commissions. Moreover, the analysis shows that it is important that a diverse range of partners collaborate. However, organizations sometimes weak knowledge of the phenomenon in play as well as of each other’s work creates problems especially in the beginning. The idea of measurability is another complicating factor since there are conflicting understandings of what is possible to measure within collaborating organizations. There is also a search for best cases that can be used as role models that totally neglects local characteristics, which raises questions of transferability. What can be concluded is that projects such as these can make a difference to single destinations with for example new policies being developed, local and international networks created and possibilities for new tourism development.
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| 7. |
- Fredman, Peter, 1965-, et al.
(författare)
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Approaches to foresight recreation and tourism in nature : Experiences from the Nordic Region
- 2023. - 1st
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Ingår i: The Routledge Handbook of Nature Based Tourism Development. - London : Taylor & Francis. - 9781003230748 - 9781032137704 ; , s. 131-148
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter discusses approaches to do foresights in outdoor recreation and tourism in nature, based on research from the Nordic countries. This region has a long-standing reputation for promoting outdoor recreation, with associated policies aiming to support this tradition for the benefit of future generations and environmental engagement. To do so successfully, one key input is improving the knowledge of outdoor recreational participation, associated trends, and future development. In this chapter, we therefore review different monitoring approaches to trend analyses as a means of forecasting participation and discuss supplementary approaches to foresight in outdoor recreation. We operationalize the Nordic context through studies undertaken in Finland, Sweden, Denmark, and Norway. Our examination shows that the tradition of national surveys and on-site visitor monitoring has proven effective. However, contemporary changes in society call for additional approaches to better understand future outdoor recreation. We therefore share experiences from several different approaches to foresight in outdoor recreation. This will inform future research as well as managers, entrepreneurs, planners and policymakers in their decision-making.
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| 8. |
- Fredman, Peter, et al.
(författare)
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Besök och besökare i fjällen : Resultat från en undersökning avseende svenskarnas fritidsaktiviteter i fjällen, besök i olika fjällområden, landskapsrelationer, fjällen i sociala medier, upplevelser av vindkraft och attityder till skyddad natur
- 2014
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Rapport (populärvet., debatt m.m.)abstract
- FörordI den här rapporten redovisas några första sammanställningar från en nationell enkätundersökning avseende svenskarnas fritidsaktiviteter i fjällen, deras besök i olika fjällområden, landskapsrelationer, fjällens roll i sociala medier, upplevelser av vindkraft och attityder till skyddad natur. Enkäten ingår som en del i projekten "Bortom konflikter" och "Den nya fjällupplevelsen" inom ramen för Naturvårdsverkets forskningssatsning"Storslagen fjällmiljö" (www.storslagnafjall.se). Utifrån materialet i denna rapport kommer framöver olika fördjupningar och kompletteringar att göras, vilka kommer redovisas påolika sätt–vetenskapligt och populärvetenskapligt. Det är vår förhoppning att dessa studier blir en viktig del i referensramen för alla de beslut som fattas av myndigheter, företag och politiker när det gäller det fortsatta arbetet för en hållbar utveckling i fjällen. För dagens och framtidens grupper, aktiviteter och ideal kommer att avgöra hur hållbar utvecklingen blir–och dagens besökare i fjällen är här en av nyckelgrupperna.
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| 9. |
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| 10. |
- Fredman, Peter, et al.
(författare)
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Dagens miljömål och framtidens fjällupplevelser: Iakttagelser av aktivitetsmönster, landskapsrelationer och kommunikationsformer
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten "Dagens miljömål och framtidens fjällupplevelser – Iakttagelser av aktivitetsmönster, landskapsrelationer och kommunikationsformer" ger inledningsvis en bakgrund till fjällupplevelser och en genomgång av de metoder som använts i projektet. Därefter följer en beskrivning av de förändringar forskarna anser kunna se i de olika datamaterial som samlats in, följt av en diskussion av dagens miljökvalitetsmål i förhållande till framtidens fjällupplevelser.
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