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| 2. |
- Nijs, Jo, et al.
(författare)
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Central sensitisation in chronic pain conditions : latest discoveries and their potential for precision medicine
- 2021
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Ingår i: The Lancet Rheumatology. - : Elsevier. - 2665-9913. ; 3:5, s. E383-E392
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Forskningsöversikt (refereegranskat)abstract
- Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms represents a diagnostic challenge for rheumatology specialists. Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, has been investigated as a reason for this discrepancy. Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Within individual pain conditions, there is substantial variation among patients in terms of presence and magnitude of central sensitisation, stressing the importance of individual assessment. Central sensitisation predicts poor treatment outcomes in multiple patient populations. The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice. These data open up new treatment perspectives, with the possibility for precision pain medicine treatment according to pain phenotyping as a logical next step. With this view, studies suggest the possibility of matching non-pharmacological approaches, or medications, or both to the central sensitisation pain
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| 3. |
- Nijs, Jo, et al.
(författare)
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Nociceptive, neuropathic, or nociplastic low back pain? : The low back pain phenotyping (BACPAP) consortium's international and multidisciplinary consensus recommendations
- 2024
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Ingår i: The Lancet Rheumatology. - : Elsevier. - 2665-9913. ; 6:3, s. e178-e188
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Tidskriftsartikel (refereegranskat)abstract
- The potential to classify low back pain as being characterised by dominant nociceptive, neuropathic, or nociplastic mechanisms is a clinically relevant issue. Preliminary evidence suggests that these low back pain phenotypes might respond differently to treatments; however, more research must be done before making specific recommendations. Accordingly, the low back pain phenotyping (BACPAP) consortium was established as a group of 36 clinicians and researchers from 13 countries (five continents) and 29 institutions, to apply a modified Nominal Group Technique methodology to develop international and multidisciplinary consensus recommendations to provide guidance for identifying the dominant pain phenotype in patients with low back pain, and potentially adapt pain management strategies. The BACPAP consortium's recommendations are also intended to provide direction for future clinical research by building on the established clinical criteria for neuropathic and nociplastic pain. The BACPAP consortium's consensus recommendations are a necessary early step in the process to determine if personalised pain medicine based on pain phenotypes is feasible for low back pain management. Therefore, these recommendations are not ready to be implemented in clinical practice until additional evidence is generated that is specific to these low back pain phenotypes.
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| 4. |
- Palmlöf, Lina, et al.
(författare)
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Does income matter for troublesome neck pain? : A population-based study on risk and prognosis
- 2012
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Ingår i: Journal of Epidemiology and Community Health. - : BMJ. - 0143-005X .- 1470-2738. ; 66:11, s. 1063-1070
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Tidskriftsartikel (refereegranskat)abstract
- Background Studies have shown associations between higher income and better health, but income has not been studied in relation to neck pain. The aims of this cohort study were to assess the sex-specific role of disposable income for onset and prognosis of neck pain in the general population and if economic stress influences such potential associations. Methods Two subcohorts were identified in the Stockholm Public Health Cohort with data from 2002. Cohort I (risk cohort) included persons without neck pain (n = 8348). Cohort II (prognostic cohort) included persons with occasional neck pain during the previous 6 months (n =0 523). Both cohorts were assessed for long duration troublesome neck pain (LDNP) in 2007. Individual income was defined as aggregated annual family income in 2002 with each family member assigned a weighted consumption share, based on salary, pensions and social benefits. LDNP in 2007 was defined as having had troublesome neck pain lasting for three or more consecutive months the previous 5 years. Association between income and LDNP, considering potential confounding, was investigated by multivariable logistic regression. Economic stress was tested as effect modifier between income and LDNP. Results In both cohorts, associations were found between lower income and a higher risk for LDNP. The results were similar between the sexes. Economic stress modified the associations in both cohorts. Conclusions Low income may be a risk as well as prognostic factor for developing LDNP. Furthermore, the results indicate that economic stress may be an underlying factor to consider when studying associations between income and neck pain.
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| 6. |
- Amiri-Mosavi, A, et al.
(författare)
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Expression of cholecystokinin-B/gastrin receptors in medullary thyroid cancer.
- 1999
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Ingår i: The European journal of surgery = Acta chirurgica. - : Oxford University Press (OUP). - 1102-4151. ; 165:7, s. 628-31
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Tidskriftsartikel (refereegranskat)abstract
- To characterise the cholecystokinin (CCK) receptor subtypes in medullary thyroid cancer by measuring the expression of CCK-A and CCK-B/gastrin receptor mRNA.
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| 7. |
- Amnå, Erik, et al.
(författare)
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En halv miljard av statens pengar riskerar att slösas bort
- 2007
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Ingår i: Göteborgs-Posten. ; 2007-09-13, s. 47-47
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Minskade anslag gör att den årliga undersökningen om våra levnadsförhållanden hotas att halveras. Det kan drabba redan svaga grupper som äldre, invandrare och ensamstående föräldrar.
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| 8. |
- Andersson, Kent, et al.
(författare)
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PAH i småföretag. Mätning av polycykliska aromatiska kolväten i arbetsmiljön.
- 1985
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Arbetstagares exponering för 11 olika polycykliska aromatiska kolväten (PAH) bl.a. bensopyren har undersökts. Huvuddelen av de undersökta komponenterna är cancerogena och mutagena. Mätningarna som är av stickprovskaraktär har utförts inom följande branscher: bilverkstad, bussgarage, gjuterier (2st), grillrestaurang, rökerier (2st), sotning (2st) samt kreosotimpregnering (3st). Provtagningen har skett genom insamling av partiklar på glasfiberfilter. Totalt har 44 prov analyserats mha HPLC-fluorescensteknik. Vid kreosotimpregnering uttogs även prov på PAH i ångfasen. Insamling skedde på en polymer adsorbent, XAD-2. Resultaten visar att halterna av bensopyren genomgående är låga. I 33 av proven understeg halten 50 ng/m3 (1% av nivågränsvärdet).Totalhalten av de 11 st PAH-föreningar som analyserats varierar kraftigt men ligger vanligtvis mellan 30-300 ng/m3. Halter omkring 5000 ng/m3 förekommer. Bensopyren-halten utgör vanligen c:a 1-5 % av totalhalten identifierade PAH. Mätningar av ett 10-tal PAH-komponenter ger en bättre uppfattning och den totala PAH-belastningen i en arbetsmiljö jämfört med mätning av enbart bensopyren eftersom bensopyrens andel av den totala PAH-halten inte är konstant utan varierar stort.
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| 9. |
- Andrean, Stefio Y., et al.
(författare)
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Measurement of the production cross section of pairs of isolated photons in pp collisions at 13 TeV with the ATLAS detector
- 2021
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Ingår i: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :11
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of prompt photon-pair production in proton-proton collisions at s√s = 13 TeV is presented. The data were recorded by the ATLAS detector at the LHC with an integrated luminosity of 139 fb−1. Events with two photons in the well-instrumented region of the detector are selected. The photons are required to be isolated and have a transverse momentum of pT,γ1(2)pT,γ1(2) > 40 (30) GeV for the leading (sub-leading) photon. The differential cross sections as functions of several observables for the diphoton system are measured and compared with theoretical predictions from state-of-the-art Monte Carlo and fixed-order calculations. The QCD predictions from next-to-next-to-leading-order calculations and multi-leg merged calculations are able to describe the measured integrated and differential cross sections within uncertainties, whereas lower-order calculations show significant deviations, demonstrating that higher-order perturbative QCD corrections are crucial for this process. The resummed predictions with parton showers additionally provide an excellent description of the low transverse-momentum regime of the diphoton system.
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