| 1. |
- Lundgren, Svante, et al.
(författare)
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From Tsitsernakaberd to Hollywood – My Armenian Journey
- 2020
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Ingår i: Armenia, mon amour : Ten Europeans Speak - Ten Europeans Speak. - 9789198410136 ; , s. 82-94
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Bokkapitel (populärvet., debatt m.m.)abstract
- Kapitel i antologin "Armenia, mon amour", redigerad av Svante Lundgren och Serafim Seppälä
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| 2. |
- Lundgren, Svante, et al.
(författare)
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Preface: Love in Time of War
- 2020
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Ingår i: Armenia, mon amour : Ten Europeans Speak - Ten Europeans Speak. - 9789198410136 ; , s. 7-9
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Bokkapitel (populärvet., debatt m.m.)abstract
- Förord till antologin "Armenia, mon amour", redigerad av Svante Lundgren och Serafim Seppälä
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| 3. |
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| 4. |
- Avedian, Vahagn, et al.
(författare)
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Oförklarligt velande om folkmordet 1915
- 2016
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Ingår i: Svenska Dagbladet. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Den rödgröna regeringen bör leva upp till tidigare löften om att erkänna folkmordet på armenier, assyrier och pontiska greker. Fler undersökningar är inget annat än en undanflykt, skriver doktoranden Vahagn Avedian och forskaren Svante Lundgren.
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| 5. |
- Bollerslev, J., et al.
(författare)
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Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a prospective, randomized trial
- 2007
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 92:5, s. 1687-92
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: The clinical presentation of primary hyperparathyroidism (pHPT) has changed during the last half century, and the diagnosis is now more often made by chance in patients with no specific symptoms. OBJECTIVE: The present study is a randomized, controlled trial that investigates the effects of parathyroidectomy or medical observation in mild asymptomatic pHPT on morbidity and quality of life (QoL). DESIGN/SETTING/PATIENTS: A total of 191 patients (26 men) with asymptomatic pHPT [mean age 64.2 +/- 7.4 (sd) yr] were recruited in the study and randomized to medical observation (serum calcium level 2.69 +/- 0.08 mmol/liter) or surgery (2.70 +/- 0.08 mmol/liter). We here report baseline and 1 (n = 119) and 2 yr data (n = 99) on those who had completed the follow-up visits by the end of the inclusion period. RESULTS: At baseline, the patients had significantly lower QoL (SF-36) and more psychological symptoms, compared with age- and sex-matched healthy subjects. The two groups were similar at baseline, and no clinically significant changes in these parameters were seen during the observation time. Calcium and PTH normalized after surgery. The areal bone mineral density increased in the group randomized to operation, whereas the bone mineral density remained stable in the medical observation group. No change in kidney function (creatinine) or blood pressure was observed longitudinally or between the groups. CONCLUSIONS: Asymptomatic patients with mild pHPT have decreased QoL and more psychological symptoms than normal controls. No benefit of operative treatment, compared with medical observation, was found on these measures so far.
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| 6. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 7. |
- Gorniok, Lukasz, et al.
(författare)
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Editorial
- 2020
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Ingår i: Nordisk judaistik - Scandinavian Jewish Studies. - : Nordisk judaistik/Scandinavian Jewish Studies. - 0348-1646 .- 2343-4929. ; 31:1, s. 1-6
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
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| 8. |
- Gorniok, Lukasz, et al.
(författare)
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Editorial
- 2020
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Ingår i: Nordisk judaistik - Scandinavian Jewish Studies. - : Nordisk judaistik/Scandinavian Jewish Studies. - 0348-1646 .- 2343-4929. ; 31:1, s. 1-6
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
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| 9. |
- Gorniok, Lukasz, et al.
(författare)
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Editorial
- 2020
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Ingår i: Nordisk Judaistik. - : Nordisk judaistik/Scandinavian Jewish Studies. - 0348-1646. ; 31:1
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
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| 10. |
- Gorniok, Lukasz, et al.
(författare)
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Editorial
- 2020
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Ingår i: Nordisk Judaistik - Scandinavian Jewish Studies. - : Nordisk judaistik/Scandinavian Jewish Studies. - 0348-1646 .- 2343-4929. ; 31:1, s. 4-6
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
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