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- Johansson, Martin, 1976-, et al.
(författare)
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Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development
- 2016
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Ingår i: Biology of Sex Differences. - : Springer Science and Business Media LLC. - 2042-6410. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Background: Renewed attention has been directed to the functions of the Y chromosome in the central nervous system during early human male development, due to the recent proposed involvement in neurodevelopmental diseases. PCDH11Y and NLGN4Y are of special interest because they belong to gene families involved in cell fate determination and formation of dendrites and axon. Methods: We used RNA sequencing, immunocytochemistry and a padlock probing and rolling circle amplification strategy, to distinguish the expression of X and Y homologs in situ in the human brain for the first time. To minimize influence of androgens on the sex differences in the brain, we focused our investigation to human embryos at 8-11 weeks post-gestation. Results: We found that the X- and Y-encoded genes are expressed in specific and heterogeneous cellular sub-populations of both glial and neuronal origins. More importantly, we found differential distribution patterns of X and Y homologs in the male developing central nervous system. Conclusions: This study has visualized the spatial distribution of PCDH11X/Y and NLGN4X/Y in human developing nervous tissue. The observed spatial distribution patterns suggest the existence of an additional layer of complexity in the development of the male CNS.
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- Lundin, Elin, 1976-, et al.
(författare)
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Experiences of rehabilitation services from the perspective of older adults with dual sensory loss : a qualitative study
- 2022
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Ingår i: International Journal of Qualitative Research on Health and Well-being.. - : Taylor & Francis. - 1748-2623 .- 1748-2631. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To describe the rehabilitation service experiences of older adults with dual sensoryloss (DSL).Methods: Twenty older adults aged ≥65 years with DSL participated in semistructuredinterviews. Inductive qualitative content analysis was conducted.Results: The participants’ experiences were classified into three main categories: 1.Maintaining and regaining function included experiences regarding interventions compensat-ing for loss of function and medical corrections; 2. Mastering the situation described theindividuals’ competence of DSL, skills acquisition and taking control; and 3. Delivery ofrehabilitation services included experiences of encounters with professionals, their attitudesand the organizational impact on accessibility and collaboration.Conclusions: It was important for participants to regain function and compensate for loss infunction and to meet others in group rehabilitation. The professionals’ attitudes were animportant factor that affected the participants’ approach to rehabilitation services.Rehabilitation services mainly focused on either VL or HL, not DSL. Based on the participants’experiences, the rehabilitation services seemed to contribute to the older adults’ well-being,participation in activities and life roles, which is consistent with the WHO’s definition ofhealthy ageing. The findings can contribute to the development of rehabilitation services forolder adults with DSL to meet the diversity of these individuals’ needs.
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| 4. |
- Lundin, Elin, 1976-
(författare)
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Older Adults with Dual Sensory Loss : Prevalence, Diagnoses & Rehabilitation Services
- 2022
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Globally, the population aged 65 years and older are predicted to double within 30 years. The risk of developing vision loss in combination with hearing loss – dual sensory loss (DSL) increases with age. DSL affects older adults within several aspects, and the main areas are communication, information, participation and orientation and mobility. Aim: The overall aim was to describe older adults with DSL regardingprevalence, diagnoses, rehabilitation and experiences with rehabilitation services in the Swedish context.Methods: Quantitative and qualitative methods were used. Data were collected by using register data, mainly medical records (Study I), and by individual interviews with older adults with DSL (Study II). In the first study, data were analysed using descriptive statistics and chi square tests, and in the second study inductive qualitative content analysis was used. Results: Study I showed that the national prevalence of severe DSL was estimated to approximately 0.08%. The result also showed statisticallysignificant differences in prevalence of severe DSL between age groups and the prevalence of severe DSL increased with age. No statistically significant difference were found between women and men regarding prevalence. Older adults with DSL had been provided with several rehabilitation services and the focus of the services were mainly on one of the senses, not on the combination of sensory losses. Sensorineural hearing loss in combination with cataracts and age-related macular degeneration were the most common diagnoses. Study II presented older adults experiences of rehabilitation services and they described that several of the rehabilitation services were significant for them to be able to communicate, participate in social events and independently perform day-to-day activities.Conclusion: It is important that rehabilitation services provided to older adults with DSL are person-centred to promote healthy aging.
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- Lundin, Elin, 1976-, et al.
(författare)
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Prevalence, diagnoses and rehabilitation services related to severe dual sensory loss (DSL) in older persons : a cross-sectional study based on medical records
- 2020
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Ingår i: International Journal of Audiology. - : Taylor & Francis. - 1499-2027 .- 1708-8186. ; 59:12, s. 921-929
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To estimate the prevalence of severe dual sensory loss (DSL) among older persons (aged >= 65 years) in the Swedish population, to identify the diagnoses that cause severe DSL, and to identify rehabilitation services in which the participants have been involved.Design: A cross-sectional design was applied. Medical records from Audiological, Low Vision, and Vision clinics from two Swedish counties were used.Study sample: 1257 adults, aged >= 65 years with severe hearing loss (HL) (>= 70 dB HL) were included, whereof 101 had decimal visual acuity <= 0.3.Results: Based on the population size in the two counties (>= 65 years, n = 127,638), the prevalence of severe DSL was approximately 0.08% in the population. Within the group having DSL (n = 101), 61% were women and 71% were aged >= 85 years. Common diagnoses were cataract and/or age-related macular degeneration (AMD) in combination with HL. The rehabilitation services offered were mainly hearing aids and various magnifiers.Conclusions: The study confirmed previous results, indicating that the prevalence of severe DSL increases with age and that sensorineural HL and cataract, AMD or glaucoma coexist. The identified rehabilitation services mainly focussed on either vision loss or HL but not on severe DSL as a complex health condition.
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