| 1. |
- Holm, Lisa, et al.
(författare)
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Lexikala profiler i några nutida romaner
- 2016
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Ingår i: Svenskans beskrivning 34 : Förhandlingar vid trettiofjärde sammankomsten. Lund den 22–24 oktober 2014 - Förhandlingar vid trettiofjärde sammankomsten. Lund den 22–24 oktober 2014. - 0347-8971. - 9789187833779 ; 74, s. 201-213
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Konferensbidrag (refereegranskat)
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| 2. |
- Agebjörn, Anders, et al.
(författare)
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Kvinna – motsatsen till man? : Ordet kvinna:s semantik
- 2016
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Ingår i: Svenskans beskrivning 34 : Förhandlingar vid Trettiofjärde sammankomsten Lund den 22–24 oktober 2014 - Förhandlingar vid Trettiofjärde sammankomsten Lund den 22–24 oktober 2014. - 0347-8971. - 9789187833779 - 9789187833786 ; 74, s. 61-77
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Konferensbidrag (refereegranskat)
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| 3. |
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| 6. |
- Bateni, Fatemeh, et al.
(författare)
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Distribution, source and ecological risk assessment of polycyclic aromatic hydrocarbons in the sediments of northern part of the Persian Gulf
- 2022
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Ingår i: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 295
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Tidskriftsartikel (refereegranskat)abstract
- Distribution, sources, and ecological risk of 43 compounds of polycyclic aromatic hydrocarbons (PAHs) in surficial sediments of the Persian Gulf were investigated. The sediments were sampled from 60 offshore stations during an oceanographic cruise in the winter of 2012. Gas chromatography high-resolution mass spectrometry was used for the PAHs determinations in sediment samples. The concentrations of 21 parent PAHs, 7 methylated PAHs, 11 oxygenated PAHs and 4 nitrated PAHs were 9.0–201.5 ng g−1 dw, 3.3–60.3 ng g−1 dw, 15.2–172.7 ng g−1 dw and 0.1–8.3 ng g−1 dw, respectively. Among 21 parental PAHs, naphthalene (29.35 ng g−1 dw), phenanthrene (4.6 ng g−1 dw), and pyrene (3.18 ng g−1 dw) were the most abundant compound. 1-acenaphthenone (43.41 ng g−1 dw) and 2-methylnaphthalene (7.15 ng g−1 dw) showed the highest concentration in the oxy- and methyl-PAHs, respectively. The concentrations of nitro-PAHs were between not detected to 4 ng g−1 dw. According to the ecological risk assessment, the calculated total toxicity of PAHs was at below the lethal level on benthic organisms in all stations in the Persian Gulf, but there is risk of toxicity for the benthic organism in the Gulf of Oman (from the Strait of Hormuz to Jask). In general, nitrogenated and oxygenated derivatives did not show a significant risk in the study area. Based on the diagnostic ratios, the mixed sources (both petrogenic and pyrogenic) and pyrogenic sources have been identified for PAHs. Biomass combustion source has been identified for the stations near flares and gas fields. Principle component analysis-multivariate linear regression analysis for source identification shows that maritime traffic, abundant flares that burn the gas in oil, gas fields and dust storms have a major impact on the production of PAHs in this area.
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| 7. |
- Behboudi, Afrouz, 1967, et al.
(författare)
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The functional significance of absence: the chromosomal segment harboring Tp53 is absent from the T55 rat radiation hybrid mapping panel.
- 2002
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Ingår i: Genomics. - : Elsevier BV. - 0888-7543 .- 1089-8646. ; 79:6, s. 844-8
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Tidskriftsartikel (refereegranskat)abstract
- The T55 rat radiation hybrid (RH) mapping panel has been reported to retain the entire rat genome at retention frequencies between 22% and 37%. However, we found that a small segment of rat chromosome 10 harboring at least four different genes, including Tp53, was completely absent from the panel (retention frequency = 0%). Two other markers located in the vicinity exhibited much reduced retention (2-6%). RH clones are generated by transferring highly fragmented DNA into a recipient cell. There might be a strong selection against the transfer and retention of chromosome segments harboring an intact Tp53, as the action of this gene might prevent proliferation and establishment of the RH clone. Our finding further suggests that unexpected low retention or absence of chromosome segments in an RH panel may represent indications that the segments harbor genes with important functions in cell proliferation control.
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| 8. |
- Bidleman, Terry F., et al.
(författare)
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Bromoanisoles and Methoxylated Bromodiphenyl Ethers in Macroalgae from Nordic Coastal Regions
- 2019
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Ingår i: Environmental Science. - London : Royal Society of Chemistry. - 2050-7887 .- 2050-7895. ; , s. 881-892
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Tidskriftsartikel (refereegranskat)abstract
- Marine macroalgae are used worldwide for human consumption, animal feed, cosmetics and agriculture. In addition to beneficial nutrients, macroalgae contain halogenated natural products (HNPs), some of which have toxic properties similar to those of well-known anthropogenic contaminants. Sixteen species of red, green and brown macroalgae were collected in 2017–2018 from coastal waters of the northern Baltic Sea, Sweden Atlantic and Norway Atlantic, and analyzed for bromoanisoles (BAs) and methoxylated bromodiphenyl ethers (MeO-BDEs). Target compounds were quantified by gas chromatography-low resolution mass spectrometry (GC-LRMS), with qualitative confirmation in selected species by GC-high resolution mass spectrometry (GC-HRMS). Quantified compounds were 2,4-diBA, 2,4,6-triBA, 2′-MeO-BDE68, 6-MeO-BDE47, and two tribromo-MeO-BDEs and one tetrabromo-MeO-BDE with unknown bromine substituent positions. Semiquantitative results for pentabromo-MeO-BDEs were also obtained for a few species by GC-HRMS. Three extraction methods were compared; soaking in methanol, soaking in methanol–dichloromethane, and blending with mixed solvents. Extraction yields of BAs did not differ significantly (p > 0.05) with the three methods and the two soaking methods gave equivalent yields of MeO-BDEs. Extraction efficiencies of MeO-BDEs were significantly lower using the blend method (p < 0.05). For reasons of simplicity and efficiency, the soaking methods are preferred. Concentrations varied by orders of magnitude among species: ∑2BAs 57 to 57 700 and ∑5MeO-BDEs < 10 to 476 pg g−1 wet weight (ww). Macroalgae standing out with ∑2BAs >1000 pg g−1 ww were Ascophyllum nodosum, Ceramium tenuicorne, Ceramium virgatum, Fucus radicans, Fucus serratus, Fucus vesiculosus, Saccharina latissima, Laminaria digitata, and Acrosiphonia/Spongomorpha sp. Species A. nodosum, C. tenuicorne, Chara virgata, F. radicans and F. vesiculosus (Sweden Atlantic only) had ∑5MeO-BDEs >100 pg g−1ww. Profiles of individual compounds showed distinct differences among species and locations.
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| 9. |
- Bornscheuer, Lisa, 1990-, et al.
(författare)
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Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use
- 2023
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Ingår i: Genes. - 2073-4425. ; 14:9
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Tidskriftsartikel (refereegranskat)abstract
- Fatty acid amide hydrolase (FAAH) is an enzyme that degrades anandamide, an endocannabinoid that modulates mesolimbic dopamine release and, consequently, influences states of well-being. Despite these known interactions, the specific role of FAAH in subjective well-being remains underexplored. Since well-being is a dynamic trait that can fluctuate over time, we hypothesized that we could provide deeper insights into the link between FAAH and well-being using longitudinal data. To this end, we analyzed well-being data collected three years apart using the WHO (Ten) Well-Being Index and genotyped a functional polymorphism in the FAAH gene (rs324420, Pro129Thr) in a sample of 2822 individuals. We found that the A-allele of rs324420, which results in reduced FAAH activity and elevated anandamide levels, was associated with lower well-being scores at both time points (Wave I, B: −0.52, p = 0.007; Wave II, B: −0.41, p = 0.03, adjusted for age and sex). A subsequent phenome-wide association study (PheWAS) affirmed our well-being findings in the UK Biobank (N = 126,132, alternative C-allele associated with elevated happiness, p = 0.008) and revealed an additional association with alcohol dependence. In our cohort, using lagged longitudinal mediation analyses, we uncovered evidence of an indirect association between rs324420 and problematic alcohol use (AUDIT-P) through the pathway of lower well-being (indirect effect Boot: 0.015, 95% CI [0.003, 0.030], adjusted for AUDIT in Wave I). We propose that chronically elevated anandamide levels might influence disruptions in the endocannabinoid system—a biological contributor to well-being—which could, in turn, contribute to increased alcohol intake, though multiple factors may be at play. Further genetic studies and mediation analyses are needed to validate and extend these findings.
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| 10. |
- Bornscheuer, Lisa, et al.
(författare)
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The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use
- 2022
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Problematic alcohol use is a major contributor to the global burden of death and disabilities, and it represents a public health concern that has grown substantially following the COVID-19 pandemic. The available treatment options remain limited and to develop better pharmacotherapies for alcohol misuse we need to identify suitable biological targets. Previous research has implicated the brain’s endocannabinoid system (ECS) in psychiatric and stress-related outcomes, including substance use and habituation to repeated stress. Moreover, genetic variants in the cannabinoid-1 receptor gene (CNR1; CB1R) have been associated with personality traits, which are in turn predictors of substance use disorders. To date, however, no human genome-wide association study has provided evidence for an involvement of the ECS in substance use outcomes. One reason for this ECS-related “missing heritability” may be unexamined gene-environment interactions. To explore this possibility, we conducted cross-sectional analyses using DNA samples and stress-exposure data from a longitudinal Swedish population-based study (N = 2,915). Specifically, we genotyped rs2023239, a functional C/T single nucleotide polymorphism in CNR1, previously reported to be associated with CNR1 binding in the brain, subjective reward following alcohol intake, and alcohol cue-elicited brain activation. Our two outcomes of interest were (i) problematic alcohol use based on the Alcohol Use Disorders Identification Test (AUDIT), and (ii) personality trait scores based on the Five Factor Model. We found no baseline association between rs2023239 and problematic alcohol use or personality traits. However, there was a clear trend for interaction between rs2023239’s risk allele (C) and stressful life events (SLEs) in both childhood and adulthood, which predicted problematic alcohol use. Although not significant, there was also some indication that the risk allele interacted with child SLEs to increase scores on neuroticism. Our study supports the notion that the ECS can affect alcohol intake behaviors by interacting with life adversities and is—to the best of our knowledge—the first to focus on the interaction between CNR1 and stressors in both childhood and adulthood in humans. Further studies are warranted to confirm these findings.
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