SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lundkvist GB) "

Sökning: WFRF:(Lundkvist GB)

  • Resultat 1-10 av 15
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Cederroth, CR, et al. (författare)
  • Medicine in the Fourth Dimension
  • 2019
  • Ingår i: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 30:2, s. 238-250
  • Tidskriftsartikel (refereegranskat)
  •  
3.
  •  
4.
  •  
5.
  • Kwak, Y, et al. (författare)
  • Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons
  • 2008
  • Ingår i: Journal of biological rhythms. - : SAGE Publications. - 0748-7304 .- 1552-4531. ; 23:2, s. 150-159
  • Tidskriftsartikel (refereegranskat)abstract
    • The proinflammatory cytokine interferon (IFN-γ) is an immunomodulatory molecule released by immune cells. It was originally described as an antiviral agent but can also affect functions in the nervous system including circadian activity of the principal mammalian circadian pacemaker, the suprachiasmatic nucleus. IFN-γ and the synergistically acting cytokine tumor necrosis factor-α acutely decrease spontaneous excitatory postsynaptic activity and alter spiking activity in tissue preparations of the SCN. Because IFN-γ can be released chronically during infections, the authors studied the long-term effects of IFN-γ on SCN neurons by treating dispersed rat SCN cultures with IFN-γ over a 4-week period. They analyzed the effect of the treatment on the spontaneous spiking pattern and rhythmic expression of the “clock gene,” Period 1. They found that cytokine-treated cells exhibited a lower average spiking frequency and displayed a more irregular firing pattern when compared with controls. Furthermore, long-term treatment with IFN-γ in cultures obtained from a transgenic Per1-luciferase rat significantly reduced the Per1-luc rhythm amplitude in individual SCN neurons. These results show that IFN-γ can alter the electrical properties and circadian clock gene expression in SCN neurons. The authors hypothesize that IFN-γ can modulate circadian output, which may be associated with sleep and rhythm disturbances observed in certain infections and in aging.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 15

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy