| 1. |
- Alling, Christer, et al.
(författare)
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Adaptation of signal transduction in brain
- 1994
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Ingår i: EXS. - 1023-294X. ; 71, s. 19-28
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Tidskriftsartikel (refereegranskat)abstract
- Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.
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| 2. |
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| 3. |
- Sandin, Christer, et al.
(författare)
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Properties of the three-dimensional structure in the central region of the supernova remnant SNR 0540−69.3
- 2013
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 432:4, s. 2854-2868
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Tidskriftsartikel (refereegranskat)abstract
- We present and discuss new visual wavelength-range observations of the inner regions of the supernova remnant SNR 0540−69.3 that is located in the Large Magellanic Cloud (LMC). These observations provide us with more spatial and spectral information than were previously available for this object. We use these data to create a detailed three-dimensional model of the remnant, assuming linear expansion of the ejecta. With the observations and the model, we study the general three-dimensional structure of the remnant, and the influence of an active region in the remnant – a ‘blob’ – that we address in previous papers. We used the fibre-fed integral-field Visual Multi-Object Spectrograph at the Very Large Telescope of the European Southern Observatory. The observations provide us with three-dimensional data in [O iii] λ5007 and [S ii] λλ6717, 6731 at a 0.33 arcsec × 0.33 arcsec spatial sampling and a velocity resolution of about 35 km s− 1. We decomposed the two, partially overlapping, sulphur lines and used them to calculate electron densities across the remnant at a high signal-to-noise ratio. In our study, we recover results of previous studies, but we are more importantly able to obtain more detailed information than before. Our analysis reveals a structure that stretches from the position of the ‘blob’, and into the plane of the sky at a position angle of PA ≃ 60°. Assuming a remnant age of 1000 yr and the usual LMC distance, the structure has an inclination angle of about 65° to the line of sight. The position angle is close to the symmetry axis with present and past activity in the visual and the X-ray wavelength ranges. We speculate that the pulsar is positioned along this activity axis, where it has a velocity along the line of sight of a few hundred km s− 1. The ‘blob’ is most likely a region of shock activity, as it is mainly bright in [S ii]; future observations of [O ii] λλ3726, 3729 would be useful to test whether the S/O abundance ratio is higher than average for that location in the remnant. The striking resemblance in X-rays between the pulsar wind nebula (PWN) of SNR 0540−69.3 and the Crab, in combination with our findings in this paper, suggests that the symmetry axis is part of a torus in the PWN. This is in agreement with the original suggestion by Gotthelf & Wang.
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| 4. |
- Ahlberger, Christer, 1956, et al.
(författare)
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Consumption fantasies in Modern Literature 1820-1860. The making of the modern consumer
- 2010
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Ingår i: ESSHC 2010 – Material and Consumer Culture /MAT03: Homemaking, Cherishing and the Senses.
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Konferensbidrag (refereegranskat)abstract
- During the first half of the 19th century Sweden was undergoing a rapid integration with the capitalistic world economy. A fundamental part if this process was a profound change of consumption patterns among ordinary people. This change is the focus of our research project. Earlier research has focused on describing and explaining the concrete changes in consumption during this period. Today we have a reasonably good knowledge of the use of new commodities like colonial goods and textiles among different social groups and the sexes. On the other hand we still have little understanding of the context of the consumption. The methods and sources hitherto used in historical studies of emerging and changing consumption patterns simply do not allow us to fully analyse and interpret the attitudes and circumstances of the use of specific consumer items. Our research project takes as its point of departure a notion first conceived by the sociologist Werner Sombart and later developed by the historian Collin Campbell. Campbell claims in The romantic ethic and the Spirit of Modern Consumerism that the origins of the consumer society should be sought in the dreams for new commodities and the desire of satisfaction by the use of new commodities. The purchase creates however disappointment and frustration, since reality does not correspond to the hopes pinned in advance. From this frustration new needs and consumption fantasies are born. The aim of this project is to investigate how these consumption fantasies were created and what they consisted of. The British historian Maxine Berg stresses in Luxury and pleasure in eighteenth-century Britain the connection between our senses and modern consumption. She says that the ”representations of fashion are typically sexualized”. She quotes Sombart who claims that “sensuous pleasure and erotic pleasure are essentially the same”. When capitalism and industrialization extended the opportunities for consumption to the lower classes, this resulted in an obsession for fashion and luxury, a “sensual arousal”. Therefore you can say, that in the first half of the nineteenth century, along with the agrarian, the demographic and the industrial revolutions, Sweden experienced – along with other western countries – a sensual revolution. There is an extremely rich and currently underutilized source for understanding and analyzing the modern consumption society in contemporary literature. Nancy Armstrong, professor in literature, has shown in her study Desire and domestic fiction: a political history of the novel the great impact of the modern novel in 19th century England. Studies of Swedish contemporary literature, has convinced us that it can be used as a historical source. Hence our project has two specific goals: Firstly to deepen the understanding of the creation of the consumer society, and secondly to develop new methods using literature as a historical source: On the one hand, the Swedish fiction emerging during this time and pious literature, on the other.
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| 5. |
- Allmér, Hans, Lecturer, 1958-
(författare)
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Servicescape for Digital Wellness Services for Young Elderly
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis digital wellness services (DWSs) are in focus. The DWSs are services provided through digital devices, such as smartphones, bracelets, and tablets, by using digital environments such as Internet, cloud services, and websites. They can provide users with information that has an impact on their wellness, such as pulse, nutrition, and training guidance. The focus for this work on DWSs is on the age group of young elderly (60 – 75 years old). They belong to a group who were born long before digital devices and environments emerged and this factor may affect their motivation and willingness to use and benefit from DWSs.This thesis offers a framework for a digital servicescape that enables young elderly to benefit from DWSs. DWSs are produced and offered in digital servicescapes, where the interaction between the service providers and the service users occurs. The interaction can take place in different spaces like fitness studios, shopping malls or banks. DWSs for large groups of young elderly will require an ecosystem of stakeholders to develop, distribute, maintain, support, and further develop these services. An ecosystem builds on policies, strategies, processes, information, technologies, applications and stakeholders, and includes people who build, sell, manage and use the system. In order to understand the ecosystem, it is necessary to have a holistic approach to work out how its context, technology, stakeholders, and use interact with each other. A digital servicescape offers the conceptual basis for the ecosystem to form, evolve, and survive and produces platforms on which it is easy, effective, and productive to access and use DWSs.The described interaction between digital servicescape and DWSs for improved health leads to the research question: How can a digital servicescape enhance young elderly’s use of Digital Wellness Services (DWSs)?In order to answer the research question, the thesis presents different approaches that influence the young elderly’s capabilities and willingness to use and benefit from DWSs. If the young elderly follow recommendations to apply DWSs they will benefit in terms of healthier aging, reduced ill health, and a better quality of life. For developers and providers of DWSs development work will open up business opportunities if they understand the needs and demands of the young elderly. In addition, DWSs can contribute to significant health, social, and economic benefits for society in general. Proactive wellness programs for young elderly will have cumulative effects on the conditions for good health. The digital servicescape is a conceptual framework for future work on actually building the necessary platforms for DWSs.The work on this thesis follows an explorative approach. The data collection was carried out through surveys, literature review, and focus groups after which the data was sorted, analysed and interpreted. As the work progressed, a need arose to obtain insights from additional perspectives with the consequence that the additional data contributed to a deeper knowledge of the young elderly, DWSs and digital servicescape.The young elderly are, as a group, a very large market consisting of almost 100 million people in Europe alone. For the young elderly, digitalisation has been a part of their lives and its development has provided them with new opportunities to communicate. To them the interface on their digital device is where the interaction with a service provider occurs. Behind the interface, a digital servicescape and an ecosystem provide the necessary tools for the young elderly to achieve the wellness they seek. Nevertheless, to understand the target group it is important to consider four wellness dimensions: i) physical wellness, ii) social wellness, iii) emotional wellness, and iv) intellectual wellness. Together, the four dimensions form a holistic wellness approach to motivate young elderly to use DWSs. The research results show that the young elderly need to be motivated to adopt the services offered. Motivation that affects the young elderly is both intrinsic and extrinsic and this should be considered when developing and providing DWSs and digital servicescapes. Therefore, the service providers have to meet the expectations, needs, and demands of the young elderly and develop services that are suited for the target group. However, this is not enough, as this research shows that the young elderly want to be in a context where they feel safe.Information systems offer a basis for communication and interaction with and through digital devices such as smartphones, tablets, and bracelets. The Internet constitutes a platform for service and social interaction. Services offered on the Web, make it possible to do shopping, be entertained, entertain, and be involved in education, research, business and much more. The internet forms an important part of the infrastructure for DWSs and digital servicescapes.An efficient and well-designed DWS and its servicescape can create a win-win-win situation. The first part is the young elderly who can benefit from DWSs by increasing their chances of a longer, healthier, and happier life and thereby achieve wellness. The second win situation concerns the service developers and providers who can build a business by designing well-working DWSs aimed at the young elderly. Finally, the third win situation is about family, friends, and society. Well-designed DWSs can be beneficial for family and friends to help the young elderly to achieve wellness and require less support from family and friends. For society in general, there are financial benefits, as healthier and happier young elderly will reduce the demand for health care and support. Together the three win-win-win scenarios build an opportunity for a better tomorrow for all concerned. This thesis has created a foundation for continued research, testing, and development of DWSs and digital servicescapes. It has shown that there is a need for deeper understanding of the benefits a well-designed servicescape for DWSs can bring to people in general and to the group of young elderly in particular. Furthermore, there is a need for further research in the win-win-win situations when young elderly get access to digital wellness devices. A particularly interesting avenue of research would be to investigate how that digital servicescape could be designed and whether society should provide devices free of charge, at discount or with some other business model.
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| 6. |
- Aradottir, Steina, et al.
(författare)
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Phosphatidylethanol in rat organs after ethanol exposure.
- 2002
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Ingår i: Alcoholism: Clinical and Experimental Research. - 0145-6008. ; 26:4, s. 514-518
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Phosphatidylethanol (PEth) is an abnormal phospholipid formed in mammalian cells that have been exposed to ethanol. It has been suggested that PEth mediates some of the damaging effects of ethanol on cells. This study was performed to investigate the level of PEth in organs of rats after in vivo alcohol exposure. METHODS: Three exposure models were studied: (1) acute, intraperitoneal injection of ethanol (n = 3 x 3); (2) chronic, forced ethanol drinking (n = 6); and (3) chronic, free choice of ethanol (n = 20). PEth was analyzed by high-performance liquid chromatography after lipid extraction of the organs. RESULTS: One acute injection gave detectable PEth levels in most organs analyzed, with maximal levels reached after 2 hr. The highest levels were reached in intestines, stomach, and lung. No PEth was detected in skeletal muscle, pancreas, or testis. The two exposure models for oral intake of ethanol also gave detectable PEth levels in most organs. The highest levels were reached in stomach, lung, and spleen. PEth was detected in muscle only in animals with heavy total alcohol intake. CONCLUSIONS: PEth is formed in most organs of rats exposed to ethanol acutely or chronically. Variations in PEth level and rates of PEth formation and PEth degradation are organ specific.
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| 7. |
- Athlin, Simon, 1971-, et al.
(författare)
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Management of community-acquired pneumonia in immunocompetent adults : updated Swedish guidelines 2017
- 2018
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Ingår i: Infectious Diseases. - : Informa UK Limited. - 2374-4235 .- 2374-4243. ; 50:4, s. 247-272
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Forskningsöversikt (refereegranskat)abstract
- Based on expert group work, Swedish recommendations for the management of community-acquired pneumonia in adults are here updated. The management of sepsis-induced hypotension is addressed in detail, including monitoring and parenteral therapy. The importance of respiratory support in cases of acute respiratory failure is emphasized. Treatment with high-flow oxygen and non-invasive ventilation is recommended. The use of statins or steroids in general therapy is not found to be fully supported by evidence. In the management of pleural infection, new data show favourable effects of tissue plasminogen activator and deoxyribonuclease installation. Detailed recommendations for the vaccination of risk groups are afforded.
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| 8. |
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| 9. |
- Bjurberg, Maria, et al.
(författare)
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Primary treatment patterns and survival of cervical cancer in Sweden : A population-based Swedish Gynecologic Cancer Group Study
- 2019
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Ingår i: Gynecologic Oncology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0090-8258 .- 1095-6859. ; 155:2, s. 229-236
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Survival in cervical cancer has improved little over the last decades. We aimed to elucidate primary treatment patterns and survival. Methods: Population-based study of patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed 2011-2015. Main outcome was 5-year relative survival (RS). Age-standardised RS (AS-RS) was estimated for the total cohort and for the pooled study population of squamous, adenosquamous-, adenocarcinoma. Results: Median follow-up time was 4.6 years. The study population consisted of 2141 patients; 97% of the 2212 patients in the total cohort and the 5-year AS-RS was 71% and 70%, respectively. RS stage IB1: surgery alone 95% vs. 72% for definitive chemoradiotherapy (CT-RT) (p < 0.001). In stage IIA1 74% had CTRL, and 47% of operated patients received adjuvant (CT)-RT. RS stage IB2: surgically treated 81% (69% received adjuvant (CT)-RT) vs. 76% for (CT)-RT (p = 0.73). RS stage IIB: 77% for CT-RT + brachytherapy BT), 37% for RT + BT (p = 0.045) and 27% for RT-BT (p < 0.001). Stages III-IVA; <40% received CT-RT + BT, RS 45% vs. 18% for RT-BT (RR 4.1, p < 0.001). RS stage IVB 7%. Conclusion: Primary treatment of cervical cancer in Sweden adhered to evidence-based standard of care. Areas of improvement include optimising treatment for stages III-IVA, and avoiding combining surgery and radiotherapy. (C) 2019 Elsevier Inc. All rights reserved.
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| 10. |
- Borgfeldt, Christer, et al.
(författare)
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Survival in endometrial cancer in relation to minimally invasive surgery or open surgery : a Swedish Gynecologic Cancer Group (SweGCG) study
- 2021
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Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy).MethodsA population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses.ResultsIn univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival.ConclusionThe minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.
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