| 1. |
- Forsberg, Håkan, et al.
(författare)
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Methods for Enhancement of a Master of Engineering Programme
- 2019
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Konferensbidrag (refereegranskat)abstract
- This paper describes methods we used to improve our Master of Engineering programme in Dependable Aerospace Systems together with the industry. The target audience is mainly programme coordinators/managers who are in the process to develop their programmes for future demands. The two main questions we address are: Q1 – How do we ensure a good progression within a programme to ensure the industry’s current and future needs in engineering skills? and Q2 – How do we ensure students become acquainted with research during their studies? The results indicate that our suggested method to analyse programme progression through subject abilities supports developer of engineering programmes and that our approach to undergraduate research opportunities is a way forward to introduce students to research early.
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| 2. |
- Forsberg, Kristina, et al.
(författare)
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Elaboration of Safety Requirements
- 2013
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Ingår i: AIAA/IEEE Digital Avionics Systems Conference - Proceedings2013. - 9781479915385 ; , s. 7C21-7C29
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Konferensbidrag (refereegranskat)abstract
- According to the aircraft standard ARP4754A, requirements should be carefully traced and validated. A systematic methodology for safety requirements elaboration (refinement/decomposition as well as allocation management) is lacking. To overcome this lack, an ARP-aligned and DOORS implementable approach called RAP (Requirements Allocation Process) is proposed. RAP offers a textual as well as graphical means for managing safety requirements. Besides supporting requirements decomposition and allocation, RAP also supports design decisions. The usefulness of RAP is illustrated by an example, applying the approach to a High Lift System.
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| 3. |
- Thelander, Gunilla, et al.
(författare)
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Caffeine fatalities - Do sales restrictions prevent intentional intoxications?
- 2010
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Ingår i: Clinical Toxicology. - : Informa Healthcare. - 1556-3650 .- 1556-9519. ; 48:4, s. 354-358
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Tidskriftsartikel (refereegranskat)abstract
- Objective. Caffeine is widely available in beverages and in different over-the-counter products, including tablets containing 100 mg caffeine. Because intentional fatal intoxications with caffeine occur, the maximum quantity of caffeine tablets that can be bought over the counter in a single purchase was restricted from 250 to 30 in Sweden in the year 2004. The objective of this article was to study the effect of this decision on the number of fatal caffeine intoxications. Method. In Sweden 95% of all cases undergoing forensic autopsy are screened for a number of drugs including caffeine. All cases during January 1993-September 2009 with a caffeine concentration above 80 mu g/g blood were recorded. Results. During the study period toxicological investigations were performed in 83,580 forensic autopsies. Caffeine contributed to the fatal outcome in 20 cases (0.02%). Thirteen (65%) of these fatalities occurred before the introduction of the sales restriction. However, no fatal intoxications where caffeine contributed to the cause of death was recorded between May 2007 and September 2009. Conclusion. Overdoses of tablets containing caffeine can be fatal, suicides as well as accidents occur. Restricting the maximum quantity of caffeine tablets available over the counter seemed to be effective in preventing suicides because of caffeine although some time elapsed until the effect was noted. Further monitoring is required to ensure that the observed lower caffeine mortality is a sustained effect.
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| 4. |
- Zhou, Jiale, et al.
(författare)
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An Environment-Driven Ontological Approach to Requirements Elicitation for Safety-Critical Systems
- 2015
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Ingår i: 23rd IEEE International Requirements Engineering Conference RE'15. - 9781467369053 ; , s. 247-251
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Konferensbidrag (refereegranskat)abstract
- The environment, where a safety critical system (SCS) operates, is an important source from which safety requirements of the SCS can originate. By treating the system under construction as a black box, the environment is typically documented as a number of assumptions, based on which a set of environmental safety requirements will be elicited. However, it is not a trivial task in practice to capture the environmental assumptions to elicit safety requirements. The lack of certain assumptions or too strict assumptions will either result in incomplete environmental safety requirements or waste many efforts on eliciting incorrect requirements. Moreover, the variety of operating environment for an SCS will further complicate the task, since the captured assumptions are at risk of invalidity, and consequently the elicited requirements need to be revisited to ensure safety has not been compromised by the change. This short paper presents an on-going work aiming to 1) systematically organize the knowledge of system operating environment and, 2) facilitate the elicitation of environmental safety requirements. We propose an ontological approach to achieve the objectives. In particular, we utilize conceptual ontologies to organize the environment knowledge in terms of relevant environment concepts, relations among them and axioms. Environmental assumptions are captured by instantiating the environment ontology. An ontological reasoning mechanism is also provided to support elicitation of safety requirements from the captured assumptions.
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| 5. |
- Adach, Malina, et al.
(författare)
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A Combined Security Ontology based on the Unified Foundational Ontology
- 2022
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Ingår i: Proceedings - 16th IEEE International Conference on Semantic Computing, ICSC 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665434188 ; , s. 187-194
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Konferensbidrag (refereegranskat)abstract
- While ontology comparison and alignment have been extensively researched in the last decade, there are still some challenges to these disciplines, such as incomplete ontologies, those that cover only a portion of a domain, and differences in domain modeling due to varying viewpoints. Although the literature has compared ontological concepts from the same domain, comparisons of concepts from different domains (e.g., security and safety) remain unexplored. To compare the concepts of security and safety domains, a security ontology must first be created to bridge the gap between these domains. Therefore, this paper presents a Combined Security Ontology (CSO) based on the Unified Foundational Ontology (UFO) that could be compared to or aligned with other ontologies. This CSO includes the core ontological concepts and their respective relationships that had been extracted through a previous systematic literature review. The CSO concepts and their relationships were mapped to the UFO to get a common terminology that facilitates to bridge the gap between the security and safety domains. Since the proposed CSO is based on the UFO, it could be compared to or aligned with other ontologies from different domains.
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| 6. |
- Adach, Malina, et al.
(författare)
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Concepts and Relationships in Safety and Security Ontologies : A Comparative Study
- 2022
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Ingår i: 2022 6th International Conference on System Reliability and Safety, ICSRS 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665470926 ; , s. 357-364
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Konferensbidrag (refereegranskat)abstract
- Safety and security ontologies quickly become essential support for integrating heterogeneous knowledge from various sources. Today, there is little standardization of ontologies and almost no discussion of how to compare concepts and their relationships, establish a general approach to create relationships or model them in general. However, concepts with similar names are not semantically similar or compatible in some cases. In this case, the problem of correspondence arises among the concepts and relationships found in the ontologies. To solve this problem, a comparison between the Hazard Ontology (HO) and the Combined Security Ontology (CSO) is proposed, in which the value of equivalence between their concepts and their relationships was extracted and analyzed. Although the HO covers the concepts related to the safety domain and the CSO includes securityrelated concepts, both are based on the Unified Foundational Ontology (UFO). For this study, HO and CSO were compared, and the results were summarized in the form of comparison tables. Our main contribution involves the comparisons among the concepts in HO and CSO to identify equivalences and differences between the two. Due to the increasing number of ontologies, their mapping, merging, and alignment are primary challenges in bridging the gaps that exist between the safety and security domains.
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| 7. |
- Adach, Malina, et al.
(författare)
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Hazard Analysis on a System of Systems using the Hazard Ontology
- 2023
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Ingår i: 2023 18th Annual System of Systems Engineering Conference, SoSe 2023. - : Institute of Electrical and Electronics Engineers Inc.. - 9798350327236
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Konferensbidrag (refereegranskat)abstract
- Today, well-established hazard analysis techniques are available and widely used to identify hazards for single systems in various industries. However, hazard analysis techniques for a System of Systems (SoS) are not properly investigated. SoS is a complex system where multiple systems work together to achieve a common goal. However, the interaction between systems may lead to unforeseen interactions and interdependencies between systems. This increases the difficulty of identifying and assessing system failures and potential safety hazards. In this paper, we explore whether Hazard Ontology (HO) can be applied to an SoS and whether it can identify emergent hazards, their causes, sources, and consequences. To conduct our exploration, we apply the HO to a quarry automation site (an SoS) from the construction equipment domain. The results indicate that the HO is a promising technique that facilitates the identification of emergent hazards and their components.
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| 8. |
- Adach, Malina, et al.
(författare)
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Security Ontologies : A Systematic Literature Review
- 2022
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Ingår i: Lecture Notes In Computer Science. - Cham : Springer Science and Business Media Deutschland GmbH. - 9783031176036 ; , s. 36-53
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Konferensbidrag (refereegranskat)abstract
- Security ontologies have been developed to facilitate the organization and management of security knowledge. A comparison and evaluation of how these ontologies relate to one another is challenging due to their structure, size, complexity, and level of expressiveness. Differences between ontologies can be found on both the ontological and linguistic levels, resulting in errors and inconsistencies (i.e., different concept hierarchies, types of concepts, definitions) when comparing and aligning them. Moreover, many concepts related to security ontologies have not been thoroughly explored and do not fully meet security standards. By using standards, we can ensure that concepts and definitions are unified and coherent. In this study, we address these deficiencies by reviewing existing security ontologies to identify core concepts and relationships. The primary objective of the systematic literature review is to identify core concepts and relationships that are used to describe security issues. We further analyse and map these core concepts and relationships to five security standards (i.e., NIST SP 800-160, NIST SP 800-30 rev.1, NIST SP 800-27 rev.A, ISO/IEC 27001 and NISTIR 8053). As a contribution, this paper provides a set of core concepts and relationships that comply with the standards mentioned above and allow for a new security ontology to be developed.
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| 9. |
- Almby, Kristina E., et al.
(författare)
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Effects of Gastric Bypass Surgery on the Brain : Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia
- 2021
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 70:6, s. 1265-1277
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Tidskriftsartikel (refereegranskat)abstract
- While Roux-en-Y gastric bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes asymptomatic hypoglycemia. Previous work showed attenuated counterregulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. In this study, 11 subjects without diabetes with severe obesity were investigated pre- and post-RYGB during hyperinsulinemic normo-hypoglycemic clamps. Assessments were made of hormones, cognitive function, cerebral blood flow by arterial spin labeling, brain glucose metabolism by F-18-fluorodeoxyglucose (FDG) positron emission tomography, and activation of brain networks by functional MRI. Post- versus presurgery, we found a general increase of cerebral blood flow but a decrease of total brain FDG uptake during normoglycemia. During hypoglycemia, there was a marked increase in total brain FDG uptake, and this was similar for post- and presurgery, whereas hypothalamic FDG uptake was reduced during hypoglycemia. During hypoglycemia, attenuated responses of counterregulatory hormones and improvements in cognitive function were seen postsurgery. In early hypoglycemia, there was increased activation post- versus presurgery of neural networks in brain regions implicated in glucose regulation, such as the thalamus and hypothalamus. The results suggest adaptive responses of the brain that contribute to lowering of glycemia following RYGB, and the underlying mechanisms should be further elucidated.
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| 10. |
- Almby, Kristina E., et al.
(författare)
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Effects of GLP-1 on counter-regulatory responses during hypoglycemia after GBP surgery
- 2019
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Ingår i: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 181:2, s. 161-171
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of the study was to explore the role of GLP-1 receptor activation on the counter-regulation and symptoms of hypoglycemia in subjects who have undergone gastric bypass surgery (GBP).Design: Experimental hyperinsulinemic–hypoglycemic clamp study.Methods: Twelve post-GBP subjects participated in a randomized cross-over study with two hyperinsulinemic, hypoglycemic clamps (glucose nadir 2.7 mmol/L) performed on separate days with concomitant infusions of the GLP-1 analog exenatide or with saline, respectively. Continuous measurements of metabolites and counter-regulatory hormones as well as assessments of heart rate variability and symptoms of hypoglycemia were performed throughout the clamps.Results: No effect of GLP-1 receptor activation on counter-regulatory hormones (glucagon, catecholamines, cortisol, GH) or glucose infusion rate was seen, but we found indications of a downregulation of the sympathetic relative to the parasympathetic nerve activity, as reflected in heart rate variability. No significant differences in symptom of hypoglycemia were observed.Conclusions/interpretation: Short-term exposure to a GLP-1 receptor agonist does not seem to impact the counter-regulatory hormonal and metabolic responses in post-GBP subjects during hypoglycemic conditions, suggesting that the improvement in symptomatic hypoglycemia post-GBP seen following treatment with GLP-1 receptor agonists may be mediated by mechanism not directly involved in counter-regulation.
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