| 1. |
- Bixby, H., et al.
(författare)
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Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- 2019
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 569:7755, s. 260-4
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Tidskriftsartikel (refereegranskat)abstract
- Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
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| 2. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 3. |
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| 4. |
- Ekström, Erik, et al.
(författare)
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The effects of microstructure, Nb content and secondary Ruddlesden-Popper phase on thermoelectric properties in perovskite CaMn1-xNbxO3 (x=0-0.10) thin films
- 2020
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 10:13, s. 7918-7926
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Tidskriftsartikel (refereegranskat)abstract
- CaMn1-xNbxO3 (x = 0, 0.5, 0.6, 0.7 and 0.10) thin films have been grown by a two-step sputtering/annealing method. First, rock-salt-structured (Ca,Mn1-x,Nb-x)O thin films were deposited on 11 & x304;00 sapphire using reactive RF magnetron co-sputtering from elemental targets of Ca, Mn and Nb. The CaMn1-xNbxO3 films were then obtained by thermally induced phase transformation from rock-salt-structured (Ca,Mn1-xNbx)O to orthorhombic during post-deposition annealing at 700 degrees C for 3 h in oxygen flow. The X-ray diffraction patterns of pure CaMnO3 showed mixed orientation, while Nb-containing films were epitaxially grown in [101] out of-plane-direction. Scanning transmission electron microscopy showed a Ruddlesden-Popper (R-P) secondary phase in the films, which results in reduction of the electrical and thermal conductivity of CaMn1-xNbxO3. The electrical resistivity and Seebeck coefficient of the pure CaMnO3 film were measured to 2.7 omega cm and -270 mu V K-1 at room temperature, respectively. The electrical resistivity and Seebeck coefficient were reduced by alloying with Nb and was measured to 0.09 omega cm and -145 mu V K-1 for x = 0.05. Yielding a power factor of 21.5 mu W K-2 m(-1) near room temperature, nearly eight times higher than for pure CaMnO3 (2.8 mu W K-2 m(-1)). The power factors for alloyed samples are low compared to other studies on phase-pure material. This is due to high electrical resistivity originating from the secondary R-P phase. The thermal conductivity of the CaMn1-xNbxO3 films is low for all samples and is the lowest for x = 0.07 and 0.10, determined to 1.6 W m(-1) K-1. The low thermal conductivity is attributed to grain boundary scattering and the secondary R-P phase.
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| 5. |
- Green, Henrik, et al.
(författare)
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Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer
- 2009
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Ingår i: Basic & Clinical Pharmacology & Toxicology. - : Wiley-Blackwell Publishing Inc.. - 1742-7835 .- 1742-7843. ; 104:2, s. 130-137
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to evaluate the role of sequence variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients. Thirty-eight patients were treated with paclitaxel and carboplatin. The genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB1 G2677T/A and C3435T, as well as CYP3A4*1B, were determined by pyrosequencing. Phenotyping of CYP3A4 was performed in vivo with quinine as a probe. The patients were monitored for toxicity and 23 patients underwent a more extensive neurotoxicity evaluation. Patients heterozygous for G/A in position 2677 in ABCB1 had a significantly higher clearance of paclitaxel than most other ABCB1 variants. A lower clearance of paclitaxel was found for patients heterozygous for CYP2C8*3 when stratified according to the ABCB1 G2677T/A genotype. In addition, the CYP3A4 enzyme activity in vivo affected which metabolic pathway was dominant in each patient, but not the total clearance of paclitaxel. The exposure to paclitaxel correlated to the degree of neurotoxicity. Our findings suggest that interindividual variability in paclitaxel pharmacokinetics might be predicted by ABCB1 and CYP2C8 genotypes and provide useful information for individualized chemotherapy.
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| 6. |
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| 7. |
- Gröningsson, Per, et al.
(författare)
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Coronal emission from the shocked circumstellar ring of SN 1987A
- 2006
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 456:2, s. 581-589
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Tidskriftsartikel (refereegranskat)abstract
- High resolution spectra with UVES/VLT of SN 1987A from December 2000 until November 2005 show a number of high ionization lines from gas with velocities of ± 350 km s-1, emerging from the shocked gas formed by the ejecta-ring collision. These include coronal lines from [Fe X], [Fe XI] and [Fe XIV] which have increased by a factor of 20 during the observed period. The evolution of the lines is similar to that of the soft X-rays, indicating that they arise in the same component. The line ratios are consistent with those expected from radiative shocks with velocity 310{-}390 km s-1, corresponding to a shock temperature of (1.6{-}2.5)× 106 K. A fraction of the coronal emission may, however, originate in higher velocity adiabatic shocks.
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| 8. |
- Gröningsson, Per, et al.
(författare)
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High resolution spectroscopy of the inner ring of SN 1987A
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 479:3, s. 761-777
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Tidskriftsartikel (refereegranskat)abstract
- We discuss high resolution VLT/UVES observations (FWHM similar to 6 kms(-1)) from October 2002 (day similar to 5700 past explosion) of the shock interaction of SN 1987A and its circumstellar ring. A large number of narrow emission lines from the unshocked ring, with ion stages from neutral up to Ne V and Fe VII, have been identified. A nebular analysis of the narrow lines from the unshocked gas indicates gas densities of (similar to 1.5 - 5.0) x 10(3) cm(-3) and temperatures of similar to 6.5 x 10(3) - 2.4 x 104 K. This is consistent with the thermal widths of the lines. From the shocked component we observe a large range of ionization stages from neutral lines to [FeXIV]. From a nebular analysis we find that the density in the low ionization region is 4 x 10(6) - 10(7) cm-3. There is a clear difference in the high velocity extension of the low ionization lines and that of lines from [Fe X - XIV], with the latter extending up to similar to- 390 km s(-1) in the blue wing for [Fe XIV], while the low ionization lines extend to typically similar to- 260 km s(-1). For H alpha a faint extension up to similar to- 450 km s(-1) can be seen probably arising from a small fraction of shocked high density clumps. We discuss these observations in the context of radiative shock models, which are qualitatively consistent with the observations. A fraction of the high ionization lines may originate in gas which has yet not had time to cool, explaining the difference in width between the low and high ionization lines. The maximum shock velocities seen in the optical lines are similar to 510 km s(-1). We expect the maximum width of especially the low ionization lines to increase with time.
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| 9. |
- Gröningsson, Per, et al.
(författare)
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High resolution spectroscopy of the line emission from the inner circumstellar ring of SN 1987A and its hot spots
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We discuss high resolution VLT/UVES observations (FWHM ~ 6 km/s) from October 2002 (day ~5700 past explosion) of the shock interaction of SN 1987A and its circumstellar ring. A nebular analysis of the narrow lines from the unshocked gas indicates gas densities of (1.5-5.0)E3 cm-3 and temperatures of 6.5E3-2.4E4 K. This is consistent with the thermal widths of the lines. From the shocked component we observe a large range of ionization stages from neutral lines to [Fe XIV]. From a nebular analysis we find that the density in the low ionization region is 4E6-1E7 cm-3. There is a clear difference in the high velocity extension of the low ionization lines and that of lines from [Fe X-XIV], with the latter extending up to ~ -390 km/s in the blue wing for [Fe XIV], while the low ionization lines extend to typically ~ -260 km/s. For H-alpha a faint extension up to ~ -450 km/s can be seen probably arising from a small fraction of shocked high density clumps. We discuss these observations in the context of radiative shock models, which are qualitatively consistent with the observations. A fraction of the high ionization lines may originate in gas which has yet not had time to cool down, explaining the difference in width between the low and high ionization lines. The maximum shock velocities seen in the optical lines are ~ 510 km/s. We expect the maximum width of especially the low ionization lines to increase with time.
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| 10. |
- Jideus, Lena, et al.
(författare)
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Thoracic epidural anesthesia does not influence the occurrence of postoperative sustained atrial fibrillation
- 2001
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Ingår i: Annals of Thoracic Surgery. - 0003-4975 .- 1552-6259. ; 72:1, s. 65-71
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Tidskriftsartikel (refereegranskat)abstract
- Background. To evaluate whether thoracic epidural anesthesia (TEA) can reduce the incidence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG).Methods. Forty-one patients undergoing CABG were treated with TEA intraoperatively and postoperatively. Another 80 patients served as the control group. The sympathetic and parasympathetic activities were evaluated by analysis of neuropeptides, catecholamines and heart rate variability (HRV), preoperatively and postoperatively.Results. Postoperative AF occurred in 31.7% of the TEA-treated patients and in 36.3% of the untreated patients (p = 0.77). TEA significantly suppressed sympathetic activity, as indicated by a less pronounced increase of norepinephrine and epinephrine (p = 0.03, p = 0.02) and a significant decrease of neuropeptide Y (p = 0.01) postoperatively in TEA-treated patients compared to untreated patients. The HRV variable expressing sympathetic activity was significantly lower and the postoperative increase in heart rate was significantly less in the TEA group than in the control group after surgery (p = 0.01, p < 0.001). Among patients developing AF, the maximal number of supraventricular premature beats per minute increased significantly in untreated patients postoperatively but remained unchanged in TEA-treated patients (p = 0.004 versus p = 0.86).Conclusions. TEA has no effect on the incidence of postoperative sustained AF, despite a significant reduction in sympathetic activity.
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