| 1. |
- Bergknut, Magnus, et al.
(författare)
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Assessment of the availability of polycyclic aromatic hydrocarbons from gasworks soil using different extraction solvents and techniques
- 2004
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Ingår i: Environmental Toxicology and Chemistry. - : Wiley. - 0730-7268 .- 1552-8618. ; 23:8, s. 1861-1866
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Tidskriftsartikel (refereegranskat)abstract
- This study was designed to assess the availability of polycyclic aromatic hydrocarbons (PAHs) present at a gasworks site to different soil remediation techniques. The study examined the effect on PAH availability of using different organic solvents, the degree of pretreatment, and the extraction time. In total, 25 PAHs (with two to six fused rings) and five carbonyl derivatives were measured. The results indicated that the PAHs and their derivatives were bound loosely to the surface of the studied soil and that there were no significant kinetic boundaries associated with the extraction of the PAHs. Furthermore, it was concluded that the studied soil was not suitable for bioremediation, as the concentration of PAHs with low molecular weight were limited. However, pressurized liquid extraction (PLE) with methanol as the solvent extracted 97% of all PAHs and PAH-derivatives, indicating that extraction may be effective as part of a soil remediation technique for old gasworks soils.
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| 2. |
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| 3. |
- Bäcklund, Nils, 1987-, et al.
(författare)
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Salivary cortisol and cortisone can circumvent confounding effects of oral contraceptives in the short synacthen test
- 2024
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 109:7, s. 1899-1906
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Tidskriftsartikel (refereegranskat)abstract
- Context: Adrenal insufficiency (AI) is usually diagnosed by low plasma cortisol levels following a short Synacthen test (SST). Most plasma cortisol is bound to corticosteroid-binding globulin, which is increased by estrogen in combined estrogen-progestin oral contraceptives (COCs). Women with AI using COCs are therefore at risk of having an apparently normal plasma cortisol level during SST, which would not adequately reflect AI.Objective: To test whether salivary cortisol or cortisone during SST is more robust against the COC effect and to calculate the lower reference limits (LRLs) for these to be used as tentative diagnostic cutoffs to exclude AI.Methods: Forty-one healthy women on COCs and 46 healthy women without exogenous estrogens performed an SST with collection of plasma and salivary samples at 0, 30, and 60 min after Synacthen injection. The groups were compared using regression analysis with age as covariate and the LRLs were calculated parametrically.Results: SST-stimulated plasma cortisol levels were significantly higher in the COC group versus controls, while mean salivary cortisol and cortisone levels were slightly lower in the COC group. Importantly, COC use did not significantly alter LRLs for salivary cortisol or cortisone. The smallest LRL difference between groups was seen for salivary cortisone.Conclusion: Salivary cortisol and especially salivary cortisone are considerably less affected by COC use than plasma cortisol during SST. Due to similar LRLs, a common cutoff for salivary cortisol and cortisone during SST can be used to exclude AI in premenopausal women irrespective of COC use.
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| 4. |
- Dumitrescu, Delia, et al.
(författare)
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Repetition : interactive expressions of pattern translation
- 2012
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Ingår i: Proceedings The Art of Research 2012, The art of research 2012 Making, Reflecting and understading, 28-29 November 2012 at Aalto University School of Arts, Design and Architecture Helsinki, Finland.
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Konferensbidrag (refereegranskat)abstract
- As a way of opening a space where methods from the fields of fashion design, textile design and interaction design overlap, the project Repetition intersects different methodologies through practice-based research in design. Experiments were conducted to explore ways of creating relationships between body and space by means of translating information as pattern design between garments and interactive knitted walls. By arranging a startup performance, we reflected on the expressional variables that influence the expression of the pattern translations; variables concerning the garments, the walls, the print and the movements were illustrated by the expressions found. The result formulates specific descriptions regarding accuracy and distribution of pattern translation, illustrating basic concepts of pattern formations identified in visual changes appearing in the garment. By communicating our understanding of basic expressions, Repetition aims to formulate a new framework for collaborative work as a method for further design.
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| 5. |
- Einarsson, Torbjörn, et al.
(författare)
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En studie av betydelsen av den nationella överenskommelsen för civilsamhällets organisationer på det nationella planet
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- På hösten 2008 undertecknades Överenskommelsen mellan regeringen, idéburna organisationer inom det sociala området och Sveriges Kommuner och Landsting. Under de tio år som denna nationella Överenskommelse har funnits på plats så har åtminstone ett 20-tal lokala (kommunala) och regionala överenskommelser med likartad inriktning och lydelse tecknats. Baserat på tidigare forskning utgår vi i rapporten ifrån tanken att Överenskommelsen är en central komponent i den ’omförhandling av samhällskontraktet’ som vi menar pågår. I denna studie undersöker vi därmed frågan om hur den svenska Överenskommelsen på nationell nivå har påverkat förutsättningarna för det civila samhällets organisationer i det lokala. Studien är i huvudsak kvantitativ och försöker primärt besvara följande frågor om de lokala överenskommelser som har undertecknats på det sociala området under perioden 2009–2017: • Vad karakteriserar samverkan mellan civilsamhälle och ofentlig sektor inom ramen för de lokala överenskommelserna? • Vilka delar av den ideella sektorn är det som deltar i dessa lokala överenskommelser? • Leder överenskommelser på det lokala planet till någon ekonomisk eller organisatorisk tillväxt för det redan existerande civilsamhället? • Startas det fer nya ideella organisationer i samband med de lokala överenskommelserna?Sammanfattningsvis framträder några viktiga resultat både vad gäller civilsamhället inom Överenskommelsekommuner samt för de organisationer som själva anger att de deltar i lokala eller regionala överenskommelser.
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| 6. |
- Friberg, Katarina, et al.
(författare)
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En allmänning i det offentligas tjänst? : En resa i Allmänna arvsfondens spår
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Detta är en utvärdering med det övergripande syftet att beskriva och analysera den omfattande portfölj av projekt som har beviljats medel ur Allmänna arvsfonden. I huvudsak har vi utgått ifrån en analys av ett stort antal tidigare genomförda utvärderingar och ett av våra delsyften har varit att teckna portföljens karaktär. Vidare försöker vi fånga in och bättre förstå den typ av nytta som denna omfattande verksamhet kan sägas ha genererat. Det kan handla om en nytta som uppstår i samhället som helhet, för de enskilda målgrupperna eller för de idéburna organisationer ur det civila samhället som är verksamma inom de prioriterade områdena. Vi lägger i analysen särskilt fokus på den nytta som uppstår utifrån dimensionen nyskapande. Vi har slutligen, enligt vårt uppdrag från Arvsfondsdelegationen, haft ambitionen att särskilt identifiera projektverksamhetens betydelse för det civila samhället och dess organisationer.Som ram för vår utvärdering har vi valt att betrakta och förstå verksamheten vid Arvsfonden som all den verksamhet som bedrivs i dessa projekt. Det handlar om projekt som utvecklats och genomförts vid tusentals ideella föreningar, stiftelser och andra typer av organisationer runt om i Sverige med stöd av medel ur Allmänna arvsfonden. Detta är sammantaget en mycket omfattande verksamhet som under flera decennier har bedrivits av – och berört – många tusentals människor på i princip alla orter i landet.Totalt har vi analyserat 43 tidigare utvärderingar av sammanlagt cirka 2 000 projekt, som har finansierats av Allmänna arvsfonden och genomfördes under perioden 1994–2015. Med detta metaperspektiv framträder mönster i analysen på ett annat sätt än vid utvärdering av enskilda projekt. Vi har utöver detta material använt oss av Arvsfondens egna verksamhetsberättelser (2004–2016) samt ett antal statliga utredningar (SOU), lagtexter med flera dokument som underlag för att kontextualisera vår utvärdering.I vår analys blir det tydligt att verksamheten inte längre hålls samman av ett lika entydigt paket av normer och praktiker som tidigare, vare sig för Arvsfondsprojektens innehåll eller förståelsen av deras nytta. Vidare har synen på målgrupperna och deras relation till det sociala medborgarskapet utvecklats, samtidigt som dessa grupper inte är lika entydigt bestämda. Därtill är det tydligt att verksamheten också har utvecklats när det gäller betydelsen av och rollen för det organisationsliv som verksamheten i huvudsak utgår ifrån.
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| 7. |
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| 8. |
- Gutefeldt, Kerstin, 1972-, et al.
(författare)
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Clinical Examination and Self-Reported Upper Extremity Impairments in Patients with Long-Standing Type 1 Diabetes Mellitus
- 2020
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Ingår i: Journal of Diabetes Research. - : Hindawi Publishing Corporation. - 2314-6745 .- 2314-6753. ; 2020
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Tidskriftsartikel (refereegranskat)abstract
- Aim. The aims of the current study were (1) to determine the prevalence of upper extremity impairments (UEIs) in patients with type 1 diabetes by clinical investigation; (2) to investigate if self-reported impairments were concordant with clinical findings and if key questions could be identified; and (3) to investigate if answers to our self-reported questionnaire regarding UEIs are reliable. Methods. Patients with type 1 diabetes were invited to participate in a cross-sectional study of clinical and self-reported (12 items) UEIs in adjunction to ordinary scheduled clinical visit. Before the visit, a questionnaire on UEIs was filled in twice (test-retest) followed by clinical testing at the planned visit. Results. In total, 69 patients aged and with diabetes duration were included in the study. In the clinical examination, two-thirds (65%) of the patients showed one or more UEI, with failure to perform hand against back as the most common clinical finding (40%) followed by positive Phalen’s test (27%), Tinel’s test (26%), and Prayer’s sign (24%). UEIs observed by clinical examination were often bilateral, and multiple impairments often coexisted. Self-reported shoulder stiffness was associated with impaired shoulder mobility and with Prayer’s sign. Self-reported reduced hand strength was associated to lower grip force, Prayer’s sign, trigger finger, fibrosis string structures, and reduced thenar strength as well as reduced shoulder mobility. In addition, self-reporting previous surgery of carpal tunnel and trigger finger was associated with several clinical UEIs including shoulder, hand, and finger. The test-retest of the questionnaire showed a high agreement of 80-98% for reported shoulder, hand, and finger impairments. Conclusion. UEIs are common in type 1 diabetes. Self-reported shoulder stiffness and reduced hand strength might be used to capture patients with UEIs in need of clinical investigation and enhanced preventive and therapeutic strategies, as well as rehabilitative interventions.
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| 9. |
- Idborg, Helena, et al.
(författare)
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STRATIFICATION OF SLE PATIENTS FOR IMPROVED DIAGNOSIS AND TREATMENT
- 2013
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 72, s. A80-A80
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Background. Systemic autoimmune diseases (SAIDs) affect about 2% of the population in Western countries. Sufficient diagnostic criteria are lacking due to the heterogeneity within diagnostic categories and apparent overlap regarding symptoms and patterns of autoantibodies between different diagnoses. Systemic lupus erythematosus (SLE) is regarded as a prototype for SAIDs and we hypothesise that subgroups of patients with SLE may have different pathogenesis and should consequently be subject to different treatment strategies.Objectives. Our goal is to find new biomarkers to be used for the identification of more homogenous patient populations for clinical trials and to identify sub-groups of patients with high risk of for example cardiovascular events.Methods. In this study we have utilised 320 SLE patients from the Karolinska lupus cohort and 320 age and gender matched controls. The SLE cohort was characterised based on clinical, genetic and serological data and combined by multivariate data analysis in a systems biology approach to study possible subgroups. A pilot study was designed to verify and investigate suggested subgroups of SLE. Two main subgroups were defined: One group was defined as having SSA and SSB antibodies and a negative lupus anticoagulant test (LAC), i.e., a “Sjögren-like” group. The other group was defined as being negative for SSA and SSB antibodies but positive in the LAC test.i.e. an “APS-like” group. EDTA-plasma from selected patients in these two groups and controls were analysed using a mass spectrometry (MS) based proteomic and metabolomic approach. Pathway analysis was then performed on the obtained data.Results. Our pilot study showed that differences in levels of proteins and metabolites could separate disease groups from population controls. The profile/pattern of involved factors in the complement system supported a division of SLE in two major subgroups, although each individual factor was not significantly different between subgroups. Complement factor 2 (C2) and membrane attack complex (MAC) were analysed in the entire cohort with complementary methods and C2 verifies our results while the levels of MAC did not differ between SLE subgroups. The generated metabolomics data clearly separated SLE patients from controls in both gas chromatography (GC)-MS and liquid chromatography (LC)-MS data. We found for example that tryptophan was lower in the SLE patients compared to controls.Conclusions. Our systems biology approach may lead to a better understanding of the disease and its pathogenesis, and assigning patients into subgroups will result in improved diagnosis and better outcome measures of SLE.
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