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- Middeldorp, Christel M., et al.
(författare)
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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects
- 2019
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 34:3, s. 279-300
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Tidskriftsartikel (refereegranskat)abstract
- The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
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| 3. |
- Virtanen, Suvi, et al.
(författare)
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Longitudinal associations of childhood anxiety and emotional problems with substance misuse : a prospective twin study
- 2019
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Ingår i: Behavior Genetics. - : Springer. - 0001-8244 .- 1573-3297. ; 49:6, s. 529-529
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Anxiety and depression are linked to subsequent substance misuse, but it remains unclear to what extent these associations are explained by shared underlying liabilities. We investigated associations of childhood anxiety and emotional problems with subsequent substance misuse accounting for familial factors, and estimated genetic and environmental contributions to the association between emotional problems and substance misuse.In the Swedish longitudinal CATSS study, parents rated their twin children (n = 12,412) on anxiety (range: 0–3) and emotional problems (0–12) at age 9/12 years. Substance misuse was defined as (1) AUDIT score exceeding cut-off at age 18, and (2) register-based ICD-10 alcohol/drug use disorder diagnosis or alcohol/drug-related criminal conviction.Childhood anxiety symptoms were associated with a lower risk of high AUDIT score at age 18 (one-unit increase: OR = 0.71 [95% CI 0.51–0.98]). The association was similar in within-pair analyses of dizygotic twin pairs (OR = 0.57 [0.37–0.88]) and slightly higher and non-significant in monozygotic twins (OR = 0.82 [0.39–1.75]). Emotional problems were not associated with AUDIT score. Anxiety symptoms were associated with a lower risk (HR = 0.76 [0.58–0.98]) and emotional problems with a higher risk (HR = 1.23 [1.15–1.31]) of register-based substance misuse. The associations were non-sig-nificant in within-family models. The best-fitting bivariate quantitative genetic model for any emotional problems and register-based substance misuse included additive genetic and individual-specific environmental components and a shared genetic pathway explaining the covariance (rG= 0.21). Childhood anxiety and emotional problems have opposite associations with subsequent substance misuse. The association with emotional problems is mainly explained by genetic factors.
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