| 1. |
|
|
| 2. |
|
|
| 3. |
- Borland, Maria, 1967, et al.
(författare)
-
Exercise-based cardiac rehabilitation improves physical fitness in patients with permanent atrial fibrillation - A randomized controlled study
- 2020
-
Ingår i: Translational Sports Medicine. - : Hindawi Limited. - 2573-8488. ; 3:5, s. 415-425
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this multicenter randomized controlled trial was to compare physiotherapist-led exercise-based cardiac rehabilitation (PT-X) with physical activity on prescription (PAP) with regard to physical fitness, physical activity, health-related quality of life (HR-QoL), and metabolic risk markers in patients with permanent atrial fibrillation. Ninety six patients (28 women), age 74 (5) years, and ejection fraction >= 45% were randomized. An exercise tolerance test (primary outcome measure), muscle endurance tests, HR-QoL, physical activity assessments (questionnaire and accelerometer), and blood sampling were performed. The PT-X consisted of 60-minute group sessions and home-based exercise, both twice a week. The PAP consisted of 40 minutes of active walking, 4 times a week. Eighty seven patients completed the study. Exercise tolerance (maximum exercise capacity) improved significantly after PT-X (n = 40) but not after PAP (n = 47) (16 vs -3 W; P < .0001). Muscle endurance also improved after PT-X: shoulder flexion left arm (7 vs -1 repetition; P < .001), heel-lift right leg (4 vs 1 repetition; P < .05), left leg (4 vs -1 repetition; P < .001), and shoulder abduction (17 vs -4 s; P < .010). PAP significantly increased energy expenditure. Health-related quality of life and lab-tests did not differ. PT-X improved physical fitness in patients with permanent atrial fibrillation.
|
|
| 4. |
|
|
| 5. |
- Peredkov, Sergey, et al.
(författare)
-
Ioniclike energy structure of neutral core-excited states in free Kr clusters
- 2005
-
Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 72:2
-
Tidskriftsartikel (refereegranskat)abstract
- The development of electronic states in krypton clusters is investigated by high-resolution core-level electron spectroscopy. The energy ordering of bulk versus surface 3d(-1)np(n > 5) core-excited states in neutral clusters is demonstrated to be reversed to the 3d(-1)5p level situation. The cluster 3d(-1)6p,7p states are proven to be at a lower energy than the corresponding atomic levels. These findings reveal the ioniclike energy structure of the neutral cluster core-excited levels. The phenomenon is explained by a spatial spread of the excited orbitals over the cluster lattice.
|
|
| 6. |
- G. Öhrwall, M. Tchaplyguine, M. Gisselbrecht, M. Lundwall, R. Feifel, T. Rander, J. Schulz, R. R. T. Marinho, A. Lindgren, S. L. Sorensen, S. Svensson and O. Björneholm
(författare)
-
Observation of elastic scattering effects on photoelectron angular distributions in free Xe clusters
- 2003
-
Ingår i: J. Phys. B: At. Mol. Opt. Phys. ; :36, s. 3937-
-
Tidskriftsartikel (refereegranskat)
|
|
| 7. |
- Giwercman, Aleksander, et al.
(författare)
-
Testicular cancer and molecular genetics.
- 2005
-
Ingår i: Andrologia. - : Hindawi Limited. - 0303-4569 .- 1439-0272. ; 37:6, s. 224-225
-
Tidskriftsartikel (refereegranskat)
|
|
| 8. |
|
|
| 9. |
- Larne, Olivia, et al.
(författare)
-
MIR-183 in prostate cancer cells positively regulates synthesis and serum levels of prostate-specific antigen
- 2015
-
Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 68:4, s. 581-588
-
Tidskriftsartikel (refereegranskat)abstract
- Background Factors affecting serum prostate-specific antigen (PSA) levels in men are clinically important, but apart from effects mediated through the androgen receptor, they are poorly understood. Objective To investigate whether microRNA (miRNA) affects the synthesis and serum levels of PSA. Design, setting, and participants Reporter assays with PSA and KLK2 3′ untranslated regions (UTRs) to confirm posttranscriptional regulation was followed by high-throughput screening of the effect of 1129 miRNAs on PSA levels using reverse phase protein arrays (RPPAs) to identify individual regulatory miRNAs. The candidate miRNAs were investigated further in vitro by Western blot, immunofluorometrics, activity assays, quantitative reverse transcriptase polymerase chain reaction, reporter assays, and growth assays. Prostate levels of miR-183 were compared with PSA transcript and serum PSA levels in prostate cancer cohorts. Outcome measurements and statistical analysis RankProd was used to evaluate the RPPAs, and the Student t test was used for the in vitro experiments. The Spearman and Cuzick tests were used in the patient material, and overall survival was analysed by Kaplan-Meier and log-rank analysis. Results and limitations Gain-of-function screenings identified 32 miRNAs that increase PSA levels. One of these, miR-183, was found to bind the 3′ UTR of PSA directly and increase both protein and messenger RNA levels. Prostatic levels of miR-183 and serum PSA showed correlation in a cohort of 74 men. In addition, miR-183 promotes cellular growth in vitro and correlates to clinical parameters such as World Health Organisation grade and clinical progression. Conclusions The synthesis and serum levels of PSA are directly affected by miR-183 and may be a factor to consider when PSA values are evaluated in clinical settings. Patient summary These findings offer novel insights into the regulation of prostate-specific antigen and may eventually affect clinical decision making in prostate cancer. © 2014 European Association of Urology.
|
|
| 10. |
- Lindblad, A, et al.
(författare)
-
Postcollision interaction in noble gas clusters: Observation of differences in surface and bulk line shapes
- 2005
-
Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 123:21
-
Tidskriftsartikel (refereegranskat)abstract
- The surface and bulk components of the x-ray photoelectron spectra of free noble gas clusters are shown to display differences in the influence of postcollision interaction between the photoelectron and the Auger electron on the spectral line shape; the bulk component is observed to be less affected than the surface and atomic parts of the spectra. A model for postcollision interaction in nonmetallic solids and clusters is also provided which takes the polarization screening into account. Core-level photoelectron spectra of Ar, Kr, and Xe have been recorded to verify the dependence of the postcollision interaction effect on the polarizability of the sample.
|
|
