| 1. |
|
|
| 2. |
- Albinsson, Bo, 1963, et al.
(författare)
-
The Electronically Excited-States of 2-Phenylindole
- 1991
-
Ingår i: Chemical Physics. - 0301-0104. ; 151:1, s. 149-157
-
Tidskriftsartikel (refereegranskat)abstract
- The light absorption of 2-phenylindole (2PI) in the UV region (210-350 nm) is investigated by means of linear dichroism in stretched polyethylene film and fluorescence polarization anisotropy in a propylene glycol glass. Experimentally, 2PI is found to have five distinct electronic transitions located above 200 nm for which the transition moments are determined. The conclusions are supported by quantum chemical calculations and the origin of the so-called composite band is discussed. Comparison with the absorption spectrum of the fluorescent DNA binding probe DAPI is also made and 2PI is found to be an appropriate model system for the electronic transitions of DAPI.
|
|
| 3. |
|
|
| 4. |
- Högfeldt, Anna-Karin, et al.
(författare)
-
Program leadership from a Nordic perspective - Managing education development
- 2012
-
Ingår i: Proceedings of 8th International CDIO Conference, Brisbane, Australia.
-
Konferensbidrag (refereegranskat)abstract
- Nordic Five Tech (N5T) is a strategic alliance between five technical universities in Denmark, Finland, Norway and Sweden. The overall aim is to “utilize shared and complementary strengths and create synergy within education, research and innovation”. In this paper we focus on university educational development issues by investigating the program leadership at five Nordic technical universities. Specifically, the paper compares definitions, views and experiences of education leadership in the Nordic Five Tech (N5T) universities. The paper does this by, first, reviewing the definitions of roles and responsibilities for program directors at each university, and second, by presenting results from a survey carried out in March 2012 among program directors at the N5T universities. Based on this data, we analyze how program directors experience their role, their possibilities to lead, and their opportunities of learning to lead. How is time for reflection and development as leaders handled at the different universities? The paper goes on to consider what impact the mandate of the leadership role has on the possibilities for developing educational programs. For instance, how can program directors ensure that learning objectives concerning generic skills and abilities are reached? How can program directors drive implementation of integrative and value-oriented topics such as sustainable development, innovation and entrepreneurship?
|
|
| 5. |
|
|
| 6. |
- Lyng, Reidar, 1959, et al.
(författare)
-
THE CD OF LIGAND-DNA SYSTEMS .1. POLY(DG-DC) B-DNA
- 1991
-
Ingår i: Biopolymers. - : Wiley. - 0006-3525 .- 1097-0282. ; 31:14, s. 1709-1720
-
Tidskriftsartikel (refereegranskat)abstract
- A systematic theoretical study of the CD of double-stranded poly (dG-dC) and its complexes with small molecules is presented. The intrinsic CD of the polymer and the induced CD of a transition belonging to a molecule bound to DNA are calculated using the matrix method. The calculations show considerable differences between pyrimidine-purine and purine-pyrimidine binding sites, and we find that the induced CD of a groove bound molecule is one order of magnitude stronger than that of an intercalated molecule. The results form a sound basis for interpreting the CD of ligand-DNA systems in terms of molecular geometry, interactions, and spectroscopy.
|
|
| 7. |
- Lyng, Reidar, 1959, et al.
(författare)
-
THE CD OF LIGAND-DNA SYSTEMS .2. POLY(DA-DT) B-DNA
- 1992
-
Ingår i: Biopolymers. - : Wiley. - 0006-3525 .- 1097-0282. ; 32:9, s. 1201-1214
-
Tidskriftsartikel (refereegranskat)abstract
- A systematic theoretical study of the CD of [poly (dA-dT)]2 and its complexes with achiral small molecules is presented. The CD spectra of [poly (dA-dT)]2 and of poly (dA):poly(dT) are calculated for various DNA structures using the matrix method. The calculated and experimental spectra agree reasonably well for [poly(dA-dT)]2 but less well for poly(dA):poly(dT). The calculated CD spectrum of [poly(dA-dT)]2 fails to reproduce the wavelength region of 205-245 nm of the experimental spectrum. This discrepancy can be explained by a magnetic dipole allowed transition contributing significantly to the CD spectrum in this region. The induced CD of a transition moment of a molecule bound to [poly(dA-dT)]2 is also calculated. As was the case for [poly(dG-dC)]2, the induced CD of a groove bound molecule is one order of magnitude stronger than that of an intercalated molecule. The calculations also show considerable differences between pyrimidine-purine sites and purine-pyrimidine sites. Both signs and magnitudes of the CD induced into ligands bound in the minor groove agree with experimental observations.
|
|
| 8. |
|
|
| 9. |
- Rosén, Anders, Dr, et al.
(författare)
-
Mapping the CDIO Syllabus to the UNESO Key Competences for Sustainability
- 2019
-
Ingår i: Proceedings of the International CDIO Conference. - 2002-1593. ; , s. 67-84
-
Konferensbidrag (refereegranskat)abstract
- In this paper a framework of key competencies for sustainability defined by UNESCO is used to evaluate the relevance of the CDIO Syllabus for promoting engineering education for sustainable development. The evaluation is performed in two steps. First, topics, terms and concepts in the CDIO Syllabus that corresponds to the different UNESCO key competencies are identified. The second step is a qualitative discussion where areas of strong mapping are highlighted and aspects that could be better visualized or strengthened in, or added to, the Syllabus are identified. Differences in definitions of various concepts between the CDIO Syllabus and the UNESCO key competencies and the overall relation between the two frameworks are discussed. It is concluded that the CDIO Syllabus is rather well aligned with the UNESCO framework, however several opportunities (not to say needs) for strengthening the Syllabus in relation to the key competencies are identified. The UNESCO key competencies are found to be useful instruments for scrutinizing and updating the CDIO Syllabus. Other opportunities for knowledge and methods transfer between the Education for Sustainable Development (ESD) domain and the Engineering Education domain are identified. The paper is proposed to be used as basis for updating the CDIO Syllabus into a version 3.0 for maintaining its relevance in a changing world.
|
|
| 10. |
- Wittung, Pernilla, 1968, et al.
(författare)
-
Induced Chirality in PNA-PNA Duplexes
- 1995
-
Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 117:41, s. 10167-10173
-
Tidskriftsartikel (refereegranskat)abstract
- Complementary peptide nucleic acids (PNA) form Watson-Crick base-paired helical duplexes. The preferred helicity of such a duplex is determined by a chiral amino acid attached to the C-terminus. We here show that the induced helicity, as measured by circular dichroism (CD), is drastically dependent on the nucleobase sequence proximal to the chiral center. Chemically linked PNA tetramer duplexes of all 16 combinations of the two bases proximal to a carboxy terminal lysine residue were studied by CD. We conclude that the base next to the chiral center must be either a guanine or a cytosine for efficient stabilization of one helical sense. In case of cytosine, the subsequent base should preferably be a purine. We also show that the side chain properties of the C-terminal amino acid influence the resulting sense of helicity. The propagation length of induced chirality in PNA duplexes is found to be around 10 base pairs. Theoretical calculations of the circular dichroism for B-DNA, using the quantum mechanical matrix method of Schellman, give spectra in reasonable agreement with those found experimentally for PNA duplexes. The rate of helix conversion of the duplexes shows first-order kinetics with a rate constant in the range of minutes. Shorter duplexes are found to have lower activation energy and larger negative activation entropy for helix conversion, in agreement with a conversion mechanism in which a perfect helix is switched to the opposite handedness.
|
|
