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- Lyngstadaas, S. P., et al.
(författare)
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Titanium Granules for Augmentation of the Maxillary Sinus - A Multicenter Study
- 2015
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899. ; 17
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundBiomaterials are commonly used to augment the maxillary sinus floor prior to or in conjunction with dental implant installation. Recently, porous titanium granules (PTGs) have been used in oral implant surgery to stabilize implants and function as an osteoconductive matrix. PurposeTo evaluate if PTGs can be safely used in a larger population of patients, treated by different surgeons, when sinus floor augmentation was required in conjunction with implant installation. The primary endpoint was 12-month survival rate of the dental implants. Biopsies for histology were taken from the augmented area. Materials and MethodsAt five centers, 40 subjects with uni or bilateral posterior edentulism and atrophy of the posterior maxilla (3-6mm) were enrolled. In a single-stage procedure, PTG and one to three dental implants were installed in each quadrant. In total, 70 implants were included in the study. ResultsOne immobile implant was removed. The mean marginal bone loss was 0.5mm and 0.8mm, on the mesial and distal side, respectively. Histologically, all biopsies demonstrated bone ingrowth. ConclusionsThe results suggest that PTG can be safely and effectively used as augmentation material in the sinus floor when used with dental implants in a one-stage procedure.
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- Verket, A., et al.
(författare)
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Maxillary Sinus Augmentation with Porous Titanium Granules: A Microcomputed Tomography and Histologic Evaluation of Human Biopsy Specimens
- 2013
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Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786. ; 28:3, s. 721-728
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The aim of this study was to assess bone ingrowth into porous titanium granules used for maxillary sinus augmentation. Materials and Methods: Eighteen biopsy specimens from 17 patients participating in a clinical trial on sinus augmentation using porous titanium granules (PTG) were received in the laboratory. The specimens (trephine cores of 4.5 mm) were obtained 6 months after PTG placement. After being embedded in methacrylate, the samples were scanned in a microcomputed tomography (micro-CT) scanner. Specimens were then cut along the long axis and central slices were ground to 70 mu m before staining with hematoxylin and eosin. Results: The micro-CT analysis demonstrated an average bone fill of 19% (standard deviation [SD] 5.8%), whereas the graft material occupied 22.7% (SD 4.7%). The volume of newly formed bone decreased with the distance from the residual bone of the sinus floor. Two-dimensional histomorphometric analysis demonstrated a mean area of new bone of 16.1% (SD 9.4%). The PTG alone occupied 25.9% of the total mean area (SD 6.1%). The newly formed bone consisted mainly of woven bone growing in close contact with the granules and bridging the intergranular space. The remaining area was occupied predominantly by nonmineralized connective tissue. There were no signs of inflammation in any of the biopsy specimens. Conclusions: After 6 months, new bone had formed at a similar rate and quality as has been reported for other well-recognized bone graft substitutes. The new bone formed in close contact with the PTG, suggesting that the material is osteoconductive.
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