| 1. |
- Kristanl, Matej, et al.
(författare)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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Ingår i: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 2. |
- Shen, Qian, et al.
(författare)
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The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis
- 2018
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Ingår i: Molecular Plant. - : Cell Press. - 1674-2052 .- 1752-9867. ; 11:6, s. 776-788
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Tidskriftsartikel (refereegranskat)abstract
- Artemisia annua, commonly known as sweet wormwood or Qinghao, is a shrub native to China and has long been used for medicinal purposes. A. annua is now cultivated globally as the only natural source of a potent anti-malarial compound, artemisinin. Here, we report a high-quality draft assembly of the 1.74-gigabase genome of A. annua, which is highly heterozygous, rich in repetitive sequences, and contains 63 226 protein-coding genes, one of the largest numbers among the sequenced plant species. We found that, as one of a few sequenced genomes in the Asteraceae, the A. annua genome contains a large number of genes specific to this large angiosperm clade. Notably, the expansion and functional diversification of genes encoding enzymes involved in terpene biosynthesis are consistent with the evolution of the artemisinin biosynthetic pathway. We further revealed by transcriptome profiling that A. annua has evolved the sophisticated transcriptional regulatory networks underlying artemisinin biosynthesis. Based on comprehensive genomic and transcriptomic analyses we generated transgenic A. annua lines producing high levels of artemisinin, which are now ready for large-scale production and thereby will help meet the challenge of increasing global demand of artemisinin.
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| 3. |
- Simon, Tracey G., et al.
(författare)
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Association Between Aspirin Use and Risk of Hepatocellular Carcinoma
- 2018
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 4:12, s. 1683-1690
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE: Prospective data on the risk of hepatocellular carcinoma (HCC) according to dose and duration of aspirin therapy are limited.OBJECTIVE: To examine the potential benefits of aspirin use for primary HCC prevention at a range of doses and durations of use within 2 prospective, nationwide populations.DESIGN, SETTING, AND PARTICIPANTS: Pooled analysis of 2 prospective US cohort studies: the Nurses' Health Study and the Health Professionals Follow-up Study. Data were accessed from November 1, 2017, through March 7, 2018. A total of 133 371 health care professionals who reported data on aspirin use, frequency, dosage, and duration of use biennially since 1980 in women and 1986 in men were included. Individuals with a cancer diagnosis at baseline (except nonmelanoma skin cancer) were excluded.MAIN OUTCOMES AND MEASURES: Cox proportional hazards regression modelswere used to calculate multivariable adjusted hazard ratios (HRs) and 95% CIs for HCC.RESULTS: Of the 133 371 participants, 87 507 were women and 45 864 were men; in 1996, the median time of follow-up, the mean (SD) age was 62 (8) years for women and 64 (8) years for men. Over more than 26 years of follow-up encompassing 4 232 188 person-years, 108 incident HCC cases (65 women, 43 men) were documented. Compared with nonregular use, regular aspirin use (>= 2 standard-dose [325-mg] tablets per week) was associated with reduced HCC risk (adjusted HR, 0.51; 95% CI, 0.34-0.77). This benefit appeared to be dose related: compared with nonuse, the multivariable-adjusted HR for HCC was 0.87 (95% CI, 0.51-1.48) for up to 1.5 standard-dose tablets per week, 0.51 (95% CI, 0.30-0.86) for more than 1.5 to 5 tablets per week, and 0.49 (95% CI, 0.28-0.96) for more than 5 tablets per week (P for trend =.006). Significantly lower HCC risk was observed with increasing duration (P for trend =.03); this decrease was apparent with use of 1.5 or more standard-dose aspirin tablets per week for 5 or more years (adjusted HR, 0.41; 95% CI, 0.21-0.77). In contrast, use of nonaspirin nonsteroidal anti-inflammatory drugs was not significantly associated with HCC risk (adjusted HR, 1.09; 95% CI, 0.78-1.51). CONCLUSIONS AND RELEVANCE: This study suggests that regular, long-term aspirin use is associated with a dose-dependent reduction in HCC risk, which is apparent after 5 or more years of use. Similar associations were not found with nonaspirin NSAIDs. Further research appears to be needed to clarify whether aspirin use represents a feasible strategy for primary prevention against HCC.
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| 4. |
- Sun, Weiyi, et al.
(författare)
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Multi-centennial ENSO-like variability response to solar activity during the holocene
- 2024
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Ingår i: CLIMATE DYNAMICS. - 0930-7575 .- 1432-0894.
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Tidskriftsartikel (refereegranskat)abstract
- Previous reconstructions suggest a possible correlation between solar and El Nino-Southern Oscillation (ENSO) on the centennial-millennial time scales, but the mechanism remains controversial. This study conducts Holocene transient simulations and finds a significant 350-500-year cycle of ENSO-like variability during the mid-late Holocene under solar activity forcing, supported by multiple reconstructions. This multi-centennial ENSO-like variability is caused by the solar-forced low-latitude process, not the high-latitude process or internal variability. When solar radiation increases, the subtropical Asian continent-Indian Ocean thermal contrast is enhanced, increasing precipitation over the India and Bay of Bengal, which generates easterly anomaly over the Indo-Pacific warm pool. Increased solar radiation also enhances the evaporation in the cloud-free regions of western North and South Pacific, and the moisture is transported to the Maritime Continent by easterly. This increases precipitation there and strengthens the easterly anomaly over the equatorial western Pacific, which triggers the La Nina-like state. The leading coupling process for the development of La Nina-like state is zonal advective and upwelling feedback, and poleward heat advection further amplifies the equatorial eastern Pacific cooling. Findings from this study suggests that a centennial-scale El Nino-like condition might occur under solar forcings if the forecast predicts a solar minimum at the end of the 21st century.
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| 5. |
- Wang, Jing, et al.
(författare)
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Impact of centennial-scale solar activity reduction on the weakened Asian monsoon event at 9.2 ka BP
- 2023
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - 0031-0182. ; 628
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Tidskriftsartikel (refereegranskat)abstract
- The weakened Asian monsoon event at 9.2 ka has been documented in many proxy-based reconstructions, but its underlying causes are uncertain. In this study, we investigated this event from a regional monsoon perspective by analysing simulations of Holocene transient solar activity forcing using the Community Earth System Model and high-resolution proxies. Our results revealed two separate periods of decreasing precipitation in the western North Pacific (WNP) and South Asian (SA) monsoons from 9.5 to 9.2 ka, each lagging behind two remarkable weakening events (0.38 and 0.21 W m−2) in solar forcing. However, there was no significant change in East Asian summer monsoon precipitation at 9.2 ka based on our experiment. Moisture budget analysis indicated that the dynamic effects term (i.e., anomalous descending motion) figured prominently in decreasing WNP and SA monsoon precipitation. Such a change was affected by an anomalous WNP anticyclone, which was maintained by the ‘wind-evaporation-sea surface temperature’ feedback during the decay phase of the centennial-scale El Niño-like event. The development of centennial El Niño-like conditions was caused by a reduction in solar irradiance. Reduced solar irradiance induced cooling over northern Australia, generating anomalous zonal sea level pressure gradients and westerlies over the tropical Pacific, ultimately resulting in the development of an El Niño-like pattern.
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