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Sökning: WFRF:(Machens A.)

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1.
  • Machens, A., et al. (författare)
  • Advances in the management of hereditary medullary thyroid cancer
  • 2005
  • Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell. - 0954-6820 .- 1365-2796. ; 257:1, s. 50-59
  • Tidskriftsartikel (refereegranskat)abstract
    • This work draws on recent advances during the era of codon-oriented prophylactic surgery for hereditary medullary thyroid cancer (MTC). Milestones included identification of RET (REarranged during Transfection) as the susceptibility gene, introduction of prophylactic surgery on evidence of a RET germline mutation, revelation of genotype-phenotype correlations within the MEN 2 spectrum and demonstration of age-related progression of MTC. Novel surgical techniques, notably systemic microdissection and compartment-oriented surgery, have greatly enhanced surgical cure. Uncovering molecular pathways from RET genotype to MEN 2 phenotype should provide treatment options for RET mutation carriers whose MTC currently is too advanced for cure.
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2.
  • Werke, Mats, et al. (författare)
  • Geometric distortion analysis using a combination of the contour method and machining simulation
  • 2018
  • Ingår i: Procedia CIRP. - : Elsevier. - 2212-8271. ; , s. 1481-1486
  • Konferensbidrag (refereegranskat)abstract
    • During machining the material removal releases residual stresses introduced by previous process steps. This causes geometric machining distortions and thereby high rejection rates and costs. By simulating the process chain it is possible to predict this type of distortions. However, this requires advanced material models and accurate process- and material data for the individual processes. In order to simplify the modelling efforts a methodology that combines the contour method with machining simulation is proposed. The methodology is validated for an aerospace component using deep layer removal X-ray diffraction and CMM measurements. The methodology will improve possibilities to reduce machining distortions.
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