| 1. |
- Dwivedi, Om Prakash, et al.
(författare)
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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
- 2019
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; , s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individuals matched for the genotype of a common T2D-risk allele in SLC30A8, p.Arg325. In genome-edited human induced pluripotent stem cell (iPSC)-derived β-like cells, we establish that the p.Arg138* allele results in reduced SLC30A8 expression due to haploinsufficiency. In human β cells, loss of SLC30A8 leads to increased glucose responsiveness and reduced KATP channel function similar to isolated islets from carriers of the T2D-protective allele p.Trp325. These data position ZnT8 as an appealing target for treatment aimed at maintaining insulin secretion capacity in T2D.
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| 2. |
- Li, Kefei, et al.
(författare)
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Long-term field exposure of structural concretes in marine environment: state-of-the-art review by RILEM TC 289-DCM
- 2022
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Ingår i: Materials and Structures/Materiaux et Constructions. - : Springer Science and Business Media LLC. - 1359-5997. ; 55:7
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Tidskriftsartikel (refereegranskat)abstract
- This paper reviews the technical aspects related to the long-term field exposure practice in marine environments, based on the return of experiences of major marine exposure sites in world-wide scope. The long-term exposure practice helps both the research on durability mechanisms of structural concretes under real environments and the calibration of durability models to support the life-cycle management of concrete structures. The presentation of the field exposure data can be categorized into the information relevant to exposure sites, the data related to the exposed materials and specimens, the information of environmental actions, and the data related to the performance of materials. A standardized presentation of these data can help the efficiency of data sharing and exploitation. The exploitation of exposure data employs various models to represent the chloride ingress and the induced corrosion risk of the embedded steel bars. There are needs for models addressing the strong environment-material interactions, and simple yet reliable durability indicators for engineering use. The design and operation of exposure stations need the careful choice of exposure sites and specimens, the appropriate scheme for monitoring and inspection of exposed specimens, the systematic recording and management of exposure data, and the regular maintenance of exposure facilities. The support of exposure data for life-cycle management is demonstrated through the durability planning of a real project case. The good practice of long-term field exposure is summarized in the end.
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| 3. |
- Li, Kefei, et al.
(författare)
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RILEM recommendation from TC 289-DCM: guideline for designing and operating long-term marine exposure sites
- 2024
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Ingår i: Materials and Structures/Materiaux et Constructions. - 1359-5997. ; 57:3
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Tidskriftsartikel (refereegranskat)abstract
- This guideline prescribes the technical requirements for the design and operation of long-term exposure sites in marine environments. The technical content includes the design of exposure site, the monitoring of environmental conditions, the monitoring of exposed specimens, the data management and the maintenance of exposure facilities. The design of exposure site covers the choice of exposure sites, the exposure infrastructure and facilities, exposure specimens and their placing and protection. Then, the guideline defines the environmental factors to be monitored and the corresponding monitoring methods. For the exposed specimens, the guideline specifies the target performance to monitor, the sampling, the testing and the reporting of exposure results. The data management deals with such aspects as the data storage, data transmission and the data sharing. At the end, the guideline gives the principles for the maintenance of the exposure facilities. This guideline summarizes the best practice of long-term exposure in marine environments, and it is expected to support the normalization of exposure practice and to generate more added values from this practice.
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