| 1. |
- Bécoulet, A., et al.
(författare)
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Science and technology research and development in support to ITER and the Broader Approach at CEA
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10
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Tidskriftsartikel (refereegranskat)abstract
- In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented.
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| 2. |
- Adam, A, et al.
(författare)
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Abstracts from Hydrocephalus 2016.
- 2017
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Ingår i: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 14:Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Saliba-Gustafsson, P., et al.
(författare)
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Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy
- 2019
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 286:6, s. 660-675
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Tidskriftsartikel (refereegranskat)abstract
- Background Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. Objective We sought to delineate putative beneficial effects of the Pro251 variant of perlipin-2 on subclinical atherosclerosis and the mechanism by which it acts. Methods A pan-European cohort of high-risk individuals where carotid intima-media thickness has been assessed was adopted. Human primary monocyte-derived macrophages were prepared from whole blood from individuals recruited by perilipin-2 genotype or from buffy coats from the Karolinska University hospital blood central. Results The Pro251 variant of perilipin-2 is associated with decreased intima-media thickness at baseline and over 30 months of follow-up. Using human primary monocyte-derived macrophages from carriers of the beneficial Pro251 variant, we show that this variant increases autophagy activity, cholesterol efflux and a controlled inflammatory response. Through extensive mechanistic studies, we demonstrate that increase in autophagy activity is accompanied with an increase in liver-X-receptor (LXR) activity and that LXR and autophagy reciprocally activate each other in a feed-forward loop, regulated by CYP27A1 and 27OH-cholesterol. Conclusions For the first time, we show that perilipin-2 affects susceptibility to human atherosclerosis through activation of autophagy and stimulation of cholesterol efflux. We demonstrate that perilipin-2 modulates levels of the LXR ligand 27OH-cholesterol and initiates a feed-forward loop where LXR and autophagy reciprocally activate each other; the mechanism by which perilipin-2 exerts its beneficial effects on subclinical atherosclerosis.
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| 4. |
- Frisk, U., et al.
(författare)
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The Odin satellite - I. Radiometer design and test
- 2003
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 402:3, s. L27-L34
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Tidskriftsartikel (refereegranskat)abstract
- The Sub-millimetre and Millimetre Radiometer (SMR) is the main instrument on the Swedish, Canadian, Finnish and French spacecraft Odin. It consists of a 1.1 metre diameter telescope with four tuneable heterodyne receivers covering the ranges 486-504 GHz and 541-581 GHz, and one fixed at 118.75 GHz together with backends that provide spectral resolution from 150 kHz to 1 MHz. This Letter describes the Odin radiometer, its operation and performance with the data processing and calibration described in Paper II.
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| 5. |
- Hillairet, J., et al.
(författare)
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Recent progress on lower hybrid current drive and implications for ITER
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:7
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Tidskriftsartikel (refereegranskat)abstract
- The sustainment of steady-state plasmas in tokamaks requires efficient current drive systems. Lower hybrid current drive is currently the most efficient method to generate a continuous additional off-axis toroidal plasma current and to reduce the poloidal flux consumption during the plasma current ramp-up phase. The operation of the Tore Supra ITER-like lower hybrid (LH) launcher has demonstrated the capability to couple LH power at ITER-like power densities with very low reflected power during long pulses. In addition, the installation of eight 700 kW/CW klystrons at the LH transmitter has allowed increasing the total LH power in long-pulse scenarios. However, in order to achieve pure stationary LH-sustained plasmas, some R&D is needed to increase the reliability of all the systems and codes, from radio-frequency (RF) sources to plasma scenario prediction. The CEA/IRFM is addressing some of these issues by leading a R&D programme towards an ITER LH system and by the validation of an integrated LH modelling suite of codes. In 2011, the RF design of a mode converter was validated at a low power. A 500 kW/5 s RF window is currently under manufacture and will be tested at a high power in 2012 in collaboration with the National Fusion Research Institute. All of this work aims to reduce the operational risks associated with the ITER steady-state operations.
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| 6. |
- Stephens, Philip A., et al.
(författare)
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Consistent response of bird populations to climate change on two continents
- 2016
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 352:6281, s. 84-87
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Tidskriftsartikel (refereegranskat)abstract
- Global climate change is a major threat to biodiversity. Large-scale analyses have generally focused on the impacts of climate change on the geographic ranges of species and on phenology, the timing of ecological phenomena. We used long-term monitoring of the abundance of breeding birds across Europe and the United States to produce, for both regions, composite population indices for two groups of species: those for which climate suitability has been either improving or declining since 1980. The ratio of these composite indices, the climate impact indicator (CII), reflects the divergent fates of species favored or disadvantaged by climate change. The trend in CII is positive and similar in the two regions. On both continents, interspecific and spatial variation in population abundance trends are well predicted by climate suitability trends.
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| 7. |
- Agic, Heda, et al.
(författare)
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Late Ediacaran occurrences of the organic-walled microfossils Granomarginata and flask-shaped Lagoenaforma collaris gen. et sp. nov.
- 2022
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Ingår i: Geological Magazine. - : Cambridge University Press. - 0016-7568 .- 1469-5081. ; 159:7, s. 1071-1092
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Tidskriftsartikel (refereegranskat)abstract
- New occurrences of flask-shaped and envelope-bearing microfossils, including the predominantly Cambrian taxon Granomarginata, are reported from new localities, as well as from earlier in time (Ediacaran) than previously known. The stratigraphic range of Granomarginata extends into the Cambrian System, where it had a cosmopolitan distribution. This newly reported Ediacaran record includes areas from Norway (Baltica), Newfoundland (Avalonia) and Namibia (adjacent to the Kalahari Craton), and puts the oldest global occurrence of Granomarginata in the Indreelva Member (< 563 Ma) of the Stahpogieddi Formation on the Digermulen Peninsula, Arctic Norway. Although Granomarginata is rare within the assemblage, these new occurrences together with previously reported occurrences from India and Poland, suggest a potentially widespread palaeogeographic distribution of Granomarginata through the middle-late Ediacaran interval. A new flask-shaped microfossil Lagoenaforma collaris gen. et sp. nov. is also reported in horizons containing Granomarginata from the Stahpogieddi Formation in Norway and the Dabis Formation in Namibia, and flask-shaped fossils are also found in the Gibbett Hill Formation in Newfoundland. The Granomarginata-Lagoenaforma association, in addition to a low-diversity organic-walled microfossil assemblage, occurs in the strata postdating the Shuram carbon isotope excursion, and may eventually be of use in terminal Ediacaran biostratigraphy. These older occurrences of Granomarginata add to a growing record of body fossil taxa spanning the Ediacaran-Cambrian boundary.
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| 8. |
- Agic, Heda, et al.
(författare)
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Life through an Ediacaran glaciation : Shale- and diamictite-hosted organic-walled microfossil assemblages from the late Neoproterozoic of the Tanafjorden area, northern Norway
- 2024
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier. - 0031-0182 .- 1872-616X. ; 635
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Tidskriftsartikel (refereegranskat)abstract
- New organic-walled microfossil (OWM) assemblages are reported from upper Neoproterozoic glacial and interglacial siliciclastic deposits in Finnmark, northern Norway. A nearly continuous sedimentary succession of the Vestertana Group contains two glaciogenic units, the Smalfjorden and Mortensnes formations, interpreted as end-Cryogenian Marinoan and Ediacaran glaciations, respectively. We investigated the OWM record in the Nyborg, Mortensnes, and St ' ahpogieddi formations to assess the impact of a glacial interval on the diversity of microscopic eukaryotes. A modified acid-extraction technique was applied to recover OWM from the diamictite matrix. The upper Nyborg Formation contains morphologically complex Doushantuo-Pertatataka acritarchs (DPA), restricting the age of the Nyborg Formation to early-mid Ediacaran. DPA occur below the dolostones that record a negative carbon isotope excursion correlated with the Shuram anomaly and below a glacial diamictite. A decline in species richness and compositional change is observed in the Mortensnes glacial assemblage. DPA are replaced by bacterial filaments and cell aggregates. The overlying Indreelva Member, St ' ahpogieddi Formation contains Ediacara-type biota and palaeopascichnids, but only a depauperate OWM assemblage of leiosphaerids and flask-shaped microfossils characteristic of the late Ediacaran.The succession of assemblages in the Vestertana Group demonstrates a turnover from large eukaryotic OWM to a microbial community in the glacial interval, to a low diversity post-glacial assemblage during the rise of macroscopic life. We compared the Vestertana record to global DPA occurrences. Although one DPA assemblage zone postdates the Shuram excursion, no DPA occur above Ediacaran glacial diamictites in successions where those deposits are present. Considering this, and the community changes in the Vestertana succession, we suggest that DPA were affected by the onset of an Ediacaran glaciation. Lastly, we combined the biostratigraphic markers in the Vestertana Group to constrain the age of the Mortensnes diamictite.
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| 9. |
- Agic, Heda, et al.
(författare)
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Life through the 'Varanger ice ages' : microfossil record of late Neoproterozoic glacial-interglacial units from arctic Norway
- 2018
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Ingår i: Geological Society of America <em>Abstracts with Programs</em>. - : Geological Society of America.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The late Neoproterozoic strata in Finnmark (Arctic Norway) provide a good sedimentary record of Neoproterozoic glaciations on the Baltica paleocontinent. The lower Vestertana Group exposed on the Digermulen Peninsula contains two glaciogenic units, the Smalfjord and Mortensnes formations. Chemostratigraphic correlation dated the Smalfjord diamictite to the Marinoan glaciation (650-635 Ma), yet its age was also proposed to be older, per correlation to glacial units in central and southern Scandinavia. The diamictites are bracketing shales and siltstones of the interglacial Nyborg Formation. Stratigraphic, paleontological, and sedimentological data are presented from the interglacial-glacial succession, investigated by the Digermulen Early Life Research Group. Palynological analysis yielded well-preserved organic-walled microfossils (OWM) from the Nyborg Fm., and from fine-grained diamictite matrix in the Mortensnes Fm. via a modified extraction method.The interglacial Nyborg Fm. hosts a moderate diversity assemblage of prokaryotic and eukaryotic OWM, as well as acanthomorphic acritarchs such as Ceratosphaeridium, ?Cavaspina, and a novel process-bearing form. Organically preserved, enigmatic multicellular eukaryotic fossils occur in the upper Nyborg Fm. The Mortensens glacial assemblage is less diverse and contains bacterial filaments, leiosphaerids, toroidal forms, and Micrhystridium-type minute acanthomorphs.The presence of Doushantuo-Pertatataka type acritarchs in the Nyborg Fm., and small acanthomorphs in the Mortensnes diamictite corroborate an early Ediacaran age for the interglacial-glacial succession on Digermulen. In addition to the trace fossil and body-fossil record of Ediacara-biota in the overlying Stáhpogieddi Formation, the microfossil biostratigraphy suggests Marinoan and Gaskiers glaciation equivalent ages of the Varanger glaciations in Finnmark. Protistan diversity in the succession declined through and following the glaciation, until late Ediacaran.
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| 10. |
- Agić, Heda, 1989-, et al.
(författare)
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Organically-preserved multicellular eukaryote from the early Ediacaran Nyborg Formation, Arctic Norway
- 2019
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Eukaryotic multicellularity originated in the Mesoproterozoic Era and evolved multiple times since, yet early multicellular fossils are scarce until the terminal Neoproterozoic and often restricted to cases of exceptional preservation. Here we describe unusual organically-preserved fossils from mudrocks, that provide support for the presence of organisms with differentiated cells (potentially an epithelial layer) in the late Neoproterozoic. Cyathinema digermulense gen. et sp. nov. from the Nyborg Formation, Vestertana Group, Digermulen Peninsula in Arctic Norway, is a new carbonaceous organ-taxon which consists of stacked tubes with cup-shaped ends. It represents parts of a larger organism (multicellular eukaryote or a colony), likely with greater preservation potential than its other elements. Arrangement of open-ended tubes invites comparison with cells of an epithelial layer present in a variety of eukaryotic clades. This tissue may have benefitted the organism in: avoiding overgrowth, limiting fouling, reproduction, or water filtration. C. digermulense shares characteristics with extant and fossil groups including red algae and their fossils, demosponge larvae and putative sponge fossils, colonial protists, and nematophytes. Regardless of its precise affinity, C. digermulense was a complex and likely benthic marine eukaryote exhibiting cellular differentiation, and a rare occurrence of early multicellularity outside of Konservat-Lagerstatten.
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