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- Magnusson, Gudjon
(författare)
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Excessive use of medical care or rational patient behaviour? A study of a large hospital emergency department
- 1980
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The role of hospital emergency departments has over the years been gradually extended, especially in large urban areas. In Stockholm, visits to hospital emergency departments increased by 30 per cent between 1973 and 1977. The southwestern district, one of Stockholm's five health care districts, has had the highest visiting rates - since 1975 40 per cent above average. A large university hospital, the Huddinge Hospital, was opened in this district in 1972. The study is an inquiry into the use of the Huddinge Hospital emergency department by the population in its catchment area. The study encompassed not only those who used the emergency department but an approximately 10 per cent sample (17 004 people) of the population. Data was collected from the hospital emergency department, medical records, by interviews with users and non-users and from registers. During the 15 months' observation (January 1976 to March 1977) 29 per cent of the population visited the hospital emergency department (range for different subareas 22 to 46 per cent). The total number of visits was 566 per 1000 population. Compared with Swedish citizens, immigrants more often visited the emergency department (19 per cent more visits) but less often used the outpatient clinics. Marked differences between Swedes and immigrants were found in the illness behaviour. The role of proximity in the use of the hospital emergency department was anlysed by dividing the catchment area into 20 subareas. The subareas closer to the hospital had up to four times higher visiting rates compared with areas further away. The travelling distance to the hospital and the proportion of immigrants together explained 81 per cent of the differences in visiting rates between the subareas. In one geographically defined subarea, 15 per cent of the population visited district GPs while 30 per cent visited the hospital emergency department. An estimated 39 to 64 per cent of the visits to the hospital emergency department were general practitioner-type cases. In a representative sample of users and non-users of the emergency department, strong association was found between health status, social factors and the level of use of the emergency department. The hospital emergency department is a major source of medical care for the population in the catchment area. A considerable part of its diversified role is to compensate for the low capacity of the primary care services in the area.
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| 2. |
- Oddsson, Asmundur, et al.
(författare)
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Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygosity among 1.52 million individuals from six European populations. In this study, we identified 25 genes harboring protein-altering sequence variants with a strong deficit of homozygosity (10% or less of predicted homozygotes). Sequence variants in 12 of the genes cause Mendelian disease under a recessive mode of inheritance, two under a dominant mode, but variants in the remaining 11 have not been reported to cause disease. Sequence variants with a strong deficit of homozygosity are over-represented among genes essential for growth of human cell lines and genes orthologous to mouse genes known to affect viability. The function of these genes gives insight into the genetics of intrauterine lethality. We also identified 1077 genes with homozygous predicted loss-of-function genotypes not previously described, bringing the total set of genes completely knocked out in humans to 4785.
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