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| 2. |
- Liu, DJ, et al.
(författare)
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Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
- 2023
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 55:3, s. 369-
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1. This recent study—and most other large-scale human genetics studies—was mainly composed of individuals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries. Replicating earlier work, we found that cases carried a significantly higher burden of rare protein-truncating variants (PTVs) among evolutionarily constrained genes (odds ratio = 1.48; P = 5.4 × 10−6). In meta-analyses with existing datasets totaling up to 35,828 cases and 107,877 controls, this excess burden was largely consistent across five ancestral populations. Two genes (SRRM2 and AKAP11) were newly implicated as SCZ risk genes, and one gene (PCLO) was identified as shared by individuals with SCZ and those with autism. Overall, our results lend robust support to the rare allelic spectrum of the genetic architecture of SCZ being conserved across diverse human populations.
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| 4. |
- Latif, Muhammad, et al.
(författare)
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Spatiotemporal analyses of temperature and equivalent temperature and their relationship with crop health across Pakistan’s cropland
- 2024
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Ingår i: Journal of Theoretical and Applied Climatology. - 0177-798X .- 1434-4483. ; 155, s. 3473-3491
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Tidskriftsartikel (refereegranskat)abstract
- Spatiotemporal variations in temperature (T) and equivalent temperature (Te) significantly impact agricultural production across Pakistan, highlighting the need for enhanced weather and climate modeling. This study utilized four reanalysis datasets spanning a 38-year period (1981–2018): the fifth-generation European Center for Medium-Range Weather Forecasts (ECMWF) atmospheric reanalysis (ERA5), Interim ECMWF reanalysis (ERA-Interim), Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA2), and the Japanese 55-year reanalysis (JRA55). We employed National Oceanic and Atmospheric Administration/Advanced Very High-Resolution Radiometer (NOAA/AVHRR) Normalized Difference Vegetation Index (NDVI) data, a proxy for crop health, to assess the relationship between T, Te, and NDVI. This relationship is examined via regression and correlation analyses, and significance is assessed using the Mann–Kendall test and t-test. Our results show that near-surface T significantly contributes to the magnitude of Te (> 90%), whereas specific humidity (SH) has a smaller impact (< 10%). Both T and Te increase significantly across the entire tropospheric column, at 0.15 – 0.31 and 0.38 – 0.77 °C/decade, respectively. Notably, the mid-tropospheric level exhibits less warming than the upper and lower tropospheric levels. Correlation analyses of T and Te with NDVI reveal that Te exhibits a significantly stronger relationship with NDVI compared to T on both seasonal and annual timescales. The highest correlation occurs in the warm and humid summer monsoon (June – August), with Te showing a correlation of 0.50 and T correlating at 0.22 with NDVI. This study suggests that Te can serve as an additional metric for analysing near-surface heating trends in relation to crop health.
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| 5. |
- Mahmood, Zafar, et al.
(författare)
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MHD mixed convective stagnation point flow of nanofluid past a permeable stretching sheet with nanoparticles aggregation and thermal stratification
- 2022
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Using a thermally stratified water-based nanofluid and a permeable stretching sheet as a simulation environment, this research examines the impact of nanoparticle aggregation on MHD mixed convective stagnation point flow. Nanoparticle aggregation is studied using two modified models: the Krieger–Dougherty and the Maxwell–Bruggeman. The present problem's governing equations were transformed into a solvable mathematical model utilizing legitimate similarity transformations, and numerical solutions were then achieved using shooting with Runge–Kutta Fehlberg (RKF) technique in Mathematica. Equilibrium point flow toward permeable stretching surface is important for the extrusion process because it produces required heat and mass transfer patterns and identifies and clarifies fragmented flow phenomena using diagrams. Nanoparticle volume fraction was shown to have an impact on the solutions' existence range, as well. Alumina and copper nanofluids have better heat transfer properties than regular fluids. The skin friction coefficients and Nusselt number, velocity, temperature profiles for many values of the different parameters were obtained. In addition, the solutions were shown in graphs and tables, and they were explained in detail. A comparison of the current study's results with previous results for a specific instance is undertaken to verify the findings, and excellent agreement between them is observed.
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| 6. |
- Zhang, Ming, et al.
(författare)
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Identification of the target self-antigens in reperfusion injury.
- 2006
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 203:1, s. 141-52
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Tidskriftsartikel (refereegranskat)abstract
- Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
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| 7. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 8. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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